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Erschienen in: Diseases of the Colon & Rectum 1/2008

01.01.2008 | Original Contribution

Use of Intracolonic Bypass Secured by a Biodegradable Anastomotic Ring to Protect the Low Rectal Anastomosis

verfasst von: Feng Ye, M.D.,, Danyang Wang, M.D.,, Xiangming Xu, M.D.,, Fanlong Liu, M.D.,, Jianjiang Lin, M.D.

Erschienen in: Diseases of the Colon & Rectum | Ausgabe 1/2008

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Abstract

Purpose

Because of the relatively high morbidity and mortality of anastomotic leakage in patients with low rectal cancer who receive an anterior resection, many fecal diverting methods have been introduced. This study was designed to assess the efficacy and safety of the Valtrac™-secured intracolonic bypass in protecting low rectal anastomosis and to compare the efficacy and complications of Valtrac™-secured intracolonic bypass with those of loop ileostomy.

Methods

From January 2002 to April 2006, 83 patients with rectal cancer who underwent elective low anterior resection received intracolonic bypass or ileostomy. Demographics, clinical features, and operative data were recorded.

Results

Forty-four patients (53 percent) received a Valtrac™-secured intracolonic bypass and 39 patients (47 percent) a loop ileostomy. The demographics and clinical features of the groups were similar. None of the patients developed clinical anastomotic leakage. Longer overall postoperative hospital stay (21.3 ± 5.8 days) and higher costs incurred (3.1 ± 0.9 × $1,000 U.S. dollars) were observed in the ileostomy group than in the intracolonic bypass group (12.5 ± 6.3 days, 4.4 ± 1.2 × $1,000 U.S. dollars; P < 0.05). Stoma-related complications in the ileostomy group included dermatitis (12.8 percent), bleeding (2.6 percent), and intestinal obstruction after stoma closure (5.1 percent). No complications were observed in the intracolonic bypass group except for the Valtrac™ ring discharging en bloc, which compromised fecal evacuation in two cases (4.5 percent).

Conclusions

The Valtrac™-secured intracolonic bypass procedure is a safe, effective, but time-limited, diverting technique to protect an elective low colorectal anastomosis. Valtrac™-secured intracolonic bypass, in contrast to loop ileostomy, avoids stoma-related complications or readmission for closure and is associated with decreased hospital time and cost.
Literatur
1.
Zurück zum Zitat Dehni N, Schlegel RD, Cunningham C, Guiguet M, Tiret E, Parc R. Influence of a defunctioning stoma on leakage rates after low colorectal anastomosis and colonic J pouch-anal anastomosis. Br J Surg 1998;85:1114–7.PubMedCrossRef Dehni N, Schlegel RD, Cunningham C, Guiguet M, Tiret E, Parc R. Influence of a defunctioning stoma on leakage rates after low colorectal anastomosis and colonic J pouch-anal anastomosis. Br J Surg 1998;85:1114–7.PubMedCrossRef
2.
Zurück zum Zitat Arbman G, Nilsson E, Hallbook, O, Sjodahl R. Local recurrence following total mesorectal excision for rectal cancer. Br J Surg 1996;83:375–9.PubMedCrossRef Arbman G, Nilsson E, Hallbook, O, Sjodahl R. Local recurrence following total mesorectal excision for rectal cancer. Br J Surg 1996;83:375–9.PubMedCrossRef
3.
Zurück zum Zitat Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 1998;85:355–8.PubMedCrossRef Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 1998;85:355–8.PubMedCrossRef
4.
Zurück zum Zitat Laxamana A, Solomon MJ, Cohen Z. Long-term results of anterior resection using the double-stapling technique. Dis Colon Rectum 1995;38:1246–50.PubMedCrossRef Laxamana A, Solomon MJ, Cohen Z. Long-term results of anterior resection using the double-stapling technique. Dis Colon Rectum 1995;38:1246–50.PubMedCrossRef
5.
Zurück zum Zitat Scott N, Jackson P, al Jaberi T. Total mesorectal excision and local recurrence: a study of tumor spread in the mesorectum distal to rectal cancer. Br J Surg 1995;82:1031–3.PubMedCrossRef Scott N, Jackson P, al Jaberi T. Total mesorectal excision and local recurrence: a study of tumor spread in the mesorectum distal to rectal cancer. Br J Surg 1995;82:1031–3.PubMedCrossRef
6.
Zurück zum Zitat Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision of the rectum. Br J Surg 1994;81:224–6. Karanjia ND, Corder AP, Bearn P, Heald RJ. Leakage from stapled low anastomosis after total mesorectal excision of the rectum. Br J Surg 1994;81:224–6.
7.
Zurück zum Zitat Lowry A, Simmang C, Boulos P. Consensus statement of definitions for anorectal physiology and rectal cancer. Dis Colon Rectum 2001;44:915–9.PubMedCrossRef Lowry A, Simmang C, Boulos P. Consensus statement of definitions for anorectal physiology and rectal cancer. Dis Colon Rectum 2001;44:915–9.PubMedCrossRef
8.
Zurück zum Zitat Alberts JC, Parvaiz A, Moran BJ. Predicting risk and diminishing the consequences of anastomotic dehiscence following rectal resection. Colorectal Dis 2003;5:478–82.PubMedCrossRef Alberts JC, Parvaiz A, Moran BJ. Predicting risk and diminishing the consequences of anastomotic dehiscence following rectal resection. Colorectal Dis 2003;5:478–82.PubMedCrossRef
9.
Zurück zum Zitat Poon PT, Chu KW, Ho JW, Chan CW, Law WL, Wong J. Prospective evaluation of selective defunctioning stoma for low anterior resection with mesorectal excision. World J Surg 1999;23:463–7.PubMedCrossRef Poon PT, Chu KW, Ho JW, Chan CW, Law WL, Wong J. Prospective evaluation of selective defunctioning stoma for low anterior resection with mesorectal excision. World J Surg 1999;23:463–7.PubMedCrossRef
10.
Zurück zum Zitat Matthiessen P, Hallbook O, Andersson M, Rutegard J, Sjodahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 2004;6:462–9.PubMedCrossRef Matthiessen P, Hallbook O, Andersson M, Rutegard J, Sjodahl R. Risk factors for anastomotic leakage after anterior resection of the rectum. Colorectal Dis 2004;6:462–9.PubMedCrossRef
11.
Zurück zum Zitat Sorensen LT, Jorgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-Jorgensen P. Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 1999;86:927–31.PubMedCrossRef Sorensen LT, Jorgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-Jorgensen P. Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 1999;86:927–31.PubMedCrossRef
12.
Zurück zum Zitat Law WI, Chu KW, Ho JW, Chan CW. Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision. Am J Surg 2000;179:92–6.PubMedCrossRef Law WI, Chu KW, Ho JW, Chan CW. Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision. Am J Surg 2000;179:92–6.PubMedCrossRef
13.
Zurück zum Zitat Fawcett A, Shembekar M, Vashisht R, Springall RG, Nott DM. Colonic microvascular disease and anastomotic dehiscence. Br J Surg 1995;82:1544–73.CrossRef Fawcett A, Shembekar M, Vashisht R, Springall RG, Nott DM. Colonic microvascular disease and anastomotic dehiscence. Br J Surg 1995;82:1544–73.CrossRef
14.
Zurück zum Zitat Makela JT, Kiviniemi H, Laitinen S. Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 2003;46:653–60.PubMedCrossRef Makela JT, Kiviniemi H, Laitinen S. Risk factors for anastomotic leakage after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 2003;46:653–60.PubMedCrossRef
15.
Zurück zum Zitat Meade B, Moran B. Reducing the incidence and managing the consequences of anastomotic leakage after rectal resection. Acta Chir Iugosl 2004;51:19–23.PubMedCrossRef Meade B, Moran B. Reducing the incidence and managing the consequences of anastomotic leakage after rectal resection. Acta Chir Iugosl 2004;51:19–23.PubMedCrossRef
16.
Zurück zum Zitat Marusch F, Koch A, Schmidt U, et al. Value of a protective stoma in low anterior resections for rectal cancer. Dis Colon Rectum 2002;45:1164–71.PubMedCrossRef Marusch F, Koch A, Schmidt U, et al. Value of a protective stoma in low anterior resections for rectal cancer. Dis Colon Rectum 2002;45:1164–71.PubMedCrossRef
17.
Zurück zum Zitat Kanellos I, Zacharakis E, Christoforidis E, Demetriades H, Betsis D. Low anterior resection without defunctioning stoma. Tech Coloproctol 2002;6:153–7.PubMedCrossRef Kanellos I, Zacharakis E, Christoforidis E, Demetriades H, Betsis D. Low anterior resection without defunctioning stoma. Tech Coloproctol 2002;6:153–7.PubMedCrossRef
18.
Zurück zum Zitat Tschmelitsch J, Wykypiel H, Prommegger R, Bodner E. Colostomy vs. tube cecostomy for protection of a low anastomosis in rectal cancer. Arch Surg 1999;134:1385–8.PubMedCrossRef Tschmelitsch J, Wykypiel H, Prommegger R, Bodner E. Colostomy vs. tube cecostomy for protection of a low anastomosis in rectal cancer. Arch Surg 1999;134:1385–8.PubMedCrossRef
19.
Zurück zum Zitat Tocchi A, Mazzoni G, Lepre L, et al. Prospective evaluation of omentoplasty in preventing leakage of colorectal anastomosis. Dis Colon Rectum 2000;43:951–5.PubMedCrossRef Tocchi A, Mazzoni G, Lepre L, et al. Prospective evaluation of omentoplasty in preventing leakage of colorectal anastomosis. Dis Colon Rectum 2000;43:951–5.PubMedCrossRef
20.
Zurück zum Zitat Dunn CJ, Goa KL. Fibrin sealant: a review of its use in surgery and endoscopy. Drugs 1999;58:863–86.PubMedCrossRef Dunn CJ, Goa KL. Fibrin sealant: a review of its use in surgery and endoscopy. Drugs 1999;58:863–86.PubMedCrossRef
21.
Zurück zum Zitat Castrini G, Ger R, Pappalardo G, Ravo B, Trentino P, Pisapia M. Intracolonic by-pass: a new technique to prevent anastomotic complications in colon and rectal surgery. Ital J Surg Sci 1984;14:189–93.PubMed Castrini G, Ger R, Pappalardo G, Ravo B, Trentino P, Pisapia M. Intracolonic by-pass: a new technique to prevent anastomotic complications in colon and rectal surgery. Ital J Surg Sci 1984;14:189–93.PubMed
22.
Zurück zum Zitat Ravo B, Ger R. Intracolonic bypass by an intraluminal tube: an experimental study. Dis Colon Rectum 1984;27:360–5.PubMedCrossRef Ravo B, Ger R. Intracolonic bypass by an intraluminal tube: an experimental study. Dis Colon Rectum 1984;27:360–5.PubMedCrossRef
23.
Zurück zum Zitat Yoon WH, Song IS, Chang ES. Intraluminal bypass technique using a condom for protection of coloanal anastomosis. Dis Colon Rectum 1994;37:1046–7.PubMedCrossRef Yoon WH, Song IS, Chang ES. Intraluminal bypass technique using a condom for protection of coloanal anastomosis. Dis Colon Rectum 1994;37:1046–7.PubMedCrossRef
24.
Zurück zum Zitat Egozi L, Sorrento JJ, Golub R, Schultz EH. Complication of the intracolonic bypass. Report of a case. Dis Colon Rectum 1993;36:191–3.PubMedCrossRef Egozi L, Sorrento JJ, Golub R, Schultz EH. Complication of the intracolonic bypass. Report of a case. Dis Colon Rectum 1993;36:191–3.PubMedCrossRef
25.
Zurück zum Zitat Ross H. The effect of an intraluminal tube used as an internal drain on the healing of the rat colon. Dis Colon Rectum 1987;30:591–4.PubMedCrossRef Ross H. The effect of an intraluminal tube used as an internal drain on the healing of the rat colon. Dis Colon Rectum 1987;30:591–4.PubMedCrossRef
26.
Zurück zum Zitat Chen TC, Yang MJ, Chen SR, Chang CP, Chi CH. Valtrac-secured intracolonic bypass device: an experimental study. Dis Colon Rectum 1997;40:1063–7PubMedCrossRef Chen TC, Yang MJ, Chen SR, Chang CP, Chi CH. Valtrac-secured intracolonic bypass device: an experimental study. Dis Colon Rectum 1997;40:1063–7PubMedCrossRef
27.
Zurück zum Zitat Kasperk R, Schumpelick V. Sphincter preserving techniques: from anterior resection to coloanal anastomosis. Langenbecks Arch Surg 1998;383:397–401.PubMedCrossRef Kasperk R, Schumpelick V. Sphincter preserving techniques: from anterior resection to coloanal anastomosis. Langenbecks Arch Surg 1998;383:397–401.PubMedCrossRef
28.
Zurück zum Zitat Rudinskaite G, Pavalkis D. Coloanal anastomosis in rectal cancer surgery. Medicina (Kaunas) 2002;38:624–30. Rudinskaite G, Pavalkis D. Coloanal anastomosis in rectal cancer surgery. Medicina (Kaunas) 2002;38:624–30.
29.
Zurück zum Zitat Bulow S, Moesgoaard FA, Billesbolle P, Harling H. Anastomotic leakage after low anterior resection for rectal cancer. Ugeskr Leager 1997;159:297–301. Bulow S, Moesgoaard FA, Billesbolle P, Harling H. Anastomotic leakage after low anterior resection for rectal cancer. Ugeskr Leager 1997;159:297–301.
30.
Zurück zum Zitat Hallbook O, Sjodahl R. Anastomotic leakage and functional outcome after anterior resection of the rectum. Br J Surg 1996;83:60–2.PubMedCrossRef Hallbook O, Sjodahl R. Anastomotic leakage and functional outcome after anterior resection of the rectum. Br J Surg 1996;83:60–2.PubMedCrossRef
31.
Zurück zum Zitat Nesbakken A, Nygaard K, Lunde OC. Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg 2001;88:400–4.PubMedCrossRef Nesbakken A, Nygaard K, Lunde OC. Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg 2001;88:400–4.PubMedCrossRef
32.
Zurück zum Zitat Merkel S, Wang WY, Schmidt O, et al. Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma. Colorectal Dis 2001;3:154–60.PubMedCrossRef Merkel S, Wang WY, Schmidt O, et al. Locoregional recurrence in patients with anastomotic leakage after anterior resection for rectal carcinoma. Colorectal Dis 2001;3:154–60.PubMedCrossRef
33.
Zurück zum Zitat Walker KG, Bell SW, Rickard MJ, et al. Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 2004;240:255–9.PubMedCrossRef Walker KG, Bell SW, Rickard MJ, et al. Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 2004;240:255–9.PubMedCrossRef
34.
Zurück zum Zitat Chang SC, Lin JK, Yang SH, Jiang JK, Chen WC, Lin TC. Long-term outcome of anastomosis leakage after curative resection for mid and low rectal cancer. Hepatogastroenterology 2003;50:1898–902.PubMed Chang SC, Lin JK, Yang SH, Jiang JK, Chen WC, Lin TC. Long-term outcome of anastomosis leakage after curative resection for mid and low rectal cancer. Hepatogastroenterology 2003;50:1898–902.PubMed
35.
Zurück zum Zitat Ghitulescu GA, Morin N, Jetty P, Belliveau P. Revisiting the biofragmentable anastomotic ring: is it safe in colonic surgery? Can J Surg 2003;46:92–8.PubMed Ghitulescu GA, Morin N, Jetty P, Belliveau P. Revisiting the biofragmentable anastomotic ring: is it safe in colonic surgery? Can J Surg 2003;46:92–8.PubMed
36.
Zurück zum Zitat De Fina S, Franciosi C, Codecasa G, et al. The use of the biofragmentable ring (BAR-Valtrac) in colon surgery. Minerva Chir 2000;55:133–7.PubMed De Fina S, Franciosi C, Codecasa G, et al. The use of the biofragmentable ring (BAR-Valtrac) in colon surgery. Minerva Chir 2000;55:133–7.PubMed
37.
Zurück zum Zitat Wang SM, Lai IR, Liang JT, Chang KJ. Colorectal surgery using a biofragmentable anastomotic ring. J Formos Med Assoc 1996;95:798–801.PubMed Wang SM, Lai IR, Liang JT, Chang KJ. Colorectal surgery using a biofragmentable anastomotic ring. J Formos Med Assoc 1996;95:798–801.PubMed
38.
Zurück zum Zitat Ye F, Lin JJ. Clinical application of biofragmentable anastomosis ring for intestinal anastomosis. J Zhejiang Univ Med Sci 2006;35:668–72. Ye F, Lin JJ. Clinical application of biofragmentable anastomosis ring for intestinal anastomosis. J Zhejiang Univ Med Sci 2006;35:668–72.
39.
Zurück zum Zitat Luukkonen P, Jarvinen HJ, Haapiainen R. Early experience with biofragmentable anastomosis ring in colon surgery. Acta Chir Scand 1990;156:795–9.PubMed Luukkonen P, Jarvinen HJ, Haapiainen R. Early experience with biofragmentable anastomosis ring in colon surgery. Acta Chir Scand 1990;156:795–9.PubMed
40.
Zurück zum Zitat Valle M, Biancari F, Caviglia A, D’Andrea V, Baselice PF. The biofragmentable anastomosis ring in elective colon resections. Int Surg 1998;83:58–9.PubMed Valle M, Biancari F, Caviglia A, D’Andrea V, Baselice PF. The biofragmentable anastomosis ring in elective colon resections. Int Surg 1998;83:58–9.PubMed
41.
Zurück zum Zitat Corman ML, Prager ED, Hardy TG Jr, Bubrick MP. Comparison of the Valtrac biofragmentable anastomosis ring with conventional suture and stapled anastomosis in colon surgery. Results of a prospective, randomized, clinical trial. Dis Colon Rectum 1989;32:183–7.PubMedCrossRef Corman ML, Prager ED, Hardy TG Jr, Bubrick MP. Comparison of the Valtrac biofragmentable anastomosis ring with conventional suture and stapled anastomosis in colon surgery. Results of a prospective, randomized, clinical trial. Dis Colon Rectum 1989;32:183–7.PubMedCrossRef
42.
Zurück zum Zitat Machado M, Hallbook O, Goldman S, Nystrom PO, Jarhult J, Sjodahl R. Defunctioning stoma in low anterior resection with colonic pouch for rectal cancer: a comparison between two hospitals with a different policy. Dis Colon Rectum 2002;45:940–5.PubMedCrossRef Machado M, Hallbook O, Goldman S, Nystrom PO, Jarhult J, Sjodahl R. Defunctioning stoma in low anterior resection with colonic pouch for rectal cancer: a comparison between two hospitals with a different policy. Dis Colon Rectum 2002;45:940–5.PubMedCrossRef
Metadaten
Titel
Use of Intracolonic Bypass Secured by a Biodegradable Anastomotic Ring to Protect the Low Rectal Anastomosis
verfasst von
Feng Ye, M.D.,
Danyang Wang, M.D.,
Xiangming Xu, M.D.,
Fanlong Liu, M.D.,
Jianjiang Lin, M.D.
Publikationsdatum
01.01.2008
Verlag
Springer-Verlag
Erschienen in
Diseases of the Colon & Rectum / Ausgabe 1/2008
Print ISSN: 0012-3706
Elektronische ISSN: 1530-0358
DOI
https://doi.org/10.1007/s10350-007-9144-9

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