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Journal of Clinical Monitoring and Computing

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06.06.2018 | Letter to the Editor

Using the fetal oxyhaemoglobin dissociation curve to calculate the ventilation/perfusion ratio and right to left shunt in healthy newborn infants

verfasst von: Theodore Dassios, Kamal Ali, Thomas Rossor, Anne Greenough

Erschienen in: Journal of Clinical Monitoring and Computing | Ausgabe 3/2019

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Excerpt

Oxygenation impairment can be non-invasively assessed by the degree of right-to-left shunt and ventilation/perfusion inequality. The relative rightwards displacement of an individual’s oxyhaemoglobin dissociation curve (ODC) can be used to determine the reduction of the ventilation to perfusion ratio and the degree of depression of the ODC can be used to quantify the level of right to left shunt (Fig. 1). Using paired samples of peripheral oxygen saturation and fraction of inspired oxygen, a computer software can analyse and fit the data and derive a curve which represents the best fit for each infant and calculate the shunt and V_A/Q. These indexes have been described in sick newborn infants with pulmonary failure [1] and bronchopulmonary dysplasia [2‐4]. …

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Bamat N, Ghavam S, Liu Y, DeMauro SB, Jensen EA, Roberts R, et al. Reliability of a noninvasive measure of V./Q. mismatch for bronchopulmonary dysplasia. Ann Am Thorac Soc. 2015;12(5):727–33.CrossRefPubMedPubMedCentral

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Dassios T, Curley A, Morley C, Ross-Russell R. Using measurements of shunt and ventilation-to-perfusion ratio to quantify the severity of bronchopulmonary dysplasia. Neonatology. 2015;107(4):283–8.CrossRefPubMed

Dassios T, Ali K, Rossor T, Greenough A. Ventilation/perfusion ratio and right to left shunt in healthy newborn infants. J Clin Monit Comput. 2016;31(6):1229–34.

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Titel: Using the fetal oxyhaemoglobin dissociation curve to calculate the ventilation/perfusion ratio and right to left shunt in healthy newborn infants
verfasst von: Theodore Dassios
Kamal Ali
Thomas Rossor
Anne Greenough
Publikationsdatum: 06.06.2018
Verlag: Springer Netherlands
Erschienen in: Journal of Clinical Monitoring and Computing / Ausgabe 3/2019
Print ISSN: 1387-1307
Elektronische ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-018-0168-6

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Using the fetal oxyhaemoglobin dissociation curve to calculate the ventilation/perfusion ratio and right to left shunt in healthy newborn infants

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