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Neurocritical Care
Erschienen in: Neurocritical Care 2/2016

23.09.2015 | Review Article

Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury

verfasst von: Daniel Neren, Matthew D. Johnson, Wynn Legon, Salam P. Bachour, Geoffrey Ling, Afshin A. Divani

Erschienen in: Neurocritical Care | Ausgabe 2/2016

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Abstract

The objective of this paper is to review the current literature regarding the use of vagus nerve stimulation (VNS) in preclinical models of traumatic brain injury (TBI) as well as discuss the potential role of VNS along with alternative neuromodulation approaches in the treatment of human TBI. Data from previous studies have demonstrated VNS-mediated improvement following TBI in animal models. In these cases, VNS was observed to enhance motor and cognitive recovery, attenuate cerebral edema and inflammation, reduce blood brain barrier breakdown, and confer neuroprotective effects. Yet, the underlying mechanisms by which VNS enhances recovery following TBI remain to be fully elucidated. Several hypotheses have been offered including: a noradrenergic mechanism, reduction in post-TBI seizures and hyper-excitability, anti-inflammatory effects, attenuation of blood–brain barrier breakdown, and cerebral edema. We present other potential mechanisms by which VNS acts including enhancement of synaptic plasticity and recruitment of endogenous neural stem cells, stabilization of intracranial pressure, and interaction with the ghrelin system. In addition, alternative methods for the treatment of TBI including deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and focused ultrasound stimulation are discussed. Although the primary source data show that VNS improves TBI outcomes, it remains to be determined if these findings can be translated to clinical settings.
Literatur
1.
2.
Centers for Disease Control and Prevention. Report to congress on traumatic brain injury in the United States: epidemiology and rehabilitation. Atlanta: National Center for Injury Prevention and Control, Division of Unintentional Injury Prevention; 2014.
3.
Ling G, Bandak F, Armonda R, Grant G, Ecklund J. Explosive blast neurotrauma. J Neurotrauma. 2009;26(6):815–25.PubMedCrossRef
4.
Wojcik BE, Stein CR, Bagg K, Humphrey RJ, Orosco J. Traumatic brain injury hospitalizations of U.S. army soldiers deployed to Afghanistan and Iraq. Am J Prev Med. 2010;38(1):S108–16.PubMedCrossRef
5.
6.
Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Front Biosci (Landmark Ed). 2009;14:3795–813.CrossRef
7.
Lu J, Moochhala S, Kaur C, Ling E. Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury. Neurosci Lett. 2000;290(2):89–92.PubMedCrossRef
8.
Lu J, Moochhala S, Kaur C, Ling EA. Cellular inflammatory response associated with breakdown of the blood-brain barrier after closed head injury in rats. J Neurotrauma. 2001;18(4):399–408.PubMedCrossRef
9.
Beekwilder JP, Beems T. Overview of the clinical applications of vagus nerve stimulation. J Clin Neurophysiol. 2010;27(2):130–8.PubMedCrossRef
10.
Bewernick BH, Hurlemann R, Matusch A, Kayser S, Grubert C, Hadrysiewicz B, Axmacher N, Lemke M, Cooper-Mahkorn D, Cohen MX, et al. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression. Biol Psychiatry. 2010;67(2):110–6.PubMedCrossRef
11.
Hjort N, Ostergaard K, Dupont E. Improvement of sleep quality in patients with advanced Parkinson’s disease treated with deep brain stimulation of the subthalamic nucleus. Mov Disord. 2004;19(2):196–9.PubMedCrossRef
12.
Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V. Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology. 2008;33(2):368–77.PubMedCrossRef
13.
Vonck K, Raedt R, Naulaerts J, De Vogelaere F, Thiery E, Van Roost D, Aldenkamp B, Miatton M, Boon P. Vagus nerve stimulation 25 years later! What do we know about the effects on cognition? Neurosci Biobehav Rev. 2014;45:63–71.PubMedCrossRef
14.
Morris GL 3rd, Gloss D, Buchhalter J, Mack KJ, Nickels K, Harden C. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013;81(16):1453–9.PubMedPubMedCentralCrossRef
15.
Lopez NE, Krzyzaniak M, Costantini TW, De Maio A, Baird A, Eliceiri BP, Coimbra R. Vagal nerve stimulation blocks peritoneal macrophage inflammatory responsiveness after severe burn injury. Shock. 2012;38(3):294–300.PubMedPubMedCentralCrossRef
16.
Lopez NE, Krzyzaniak MJ, Costantini TW, Putnam J, Hageny AM, Eliceiri B, Coimbra R, Bansal V. Vagal nerve stimulation decreases blood-brain barrier disruption after traumatic brain injury. J Trauma Acute Care Surg. 2012;72(6):1562–6.PubMedCrossRef
17.
Smith DC, Tan AA, Duke A, Neese SL, Clough RW, Browning RA, Jensen RA. Recovery of function after vagus nerve stimulation initiated 24 hours after fluid percussion brain injury. J Neurotrauma. 2006;23(10):1549–60.PubMedCrossRef
18.
Zhou L, Lin J, Kui G, Zhang J, Yu Y. Neuroprotective effects of vagus nerve stimulation on traumatic brain injury. Neural Regen Res. 2014;9(17):1585–91.PubMedPubMedCentralCrossRef
19.
Smith DC, Modglin AA, Roosevelt RW, Neese SL, Jensen RA, Browning RA, Clough RW. Electrical stimulation of the vagus nerve enhances cognitive and motor recovery following moderate fluid percussion injury in the rat. J Neurotrauma. 2005;22(12):1485–502.PubMedPubMedCentralCrossRef
20.
Aihua L, Lu S, Liping L, Xiuru W, Hua L, Yuping W. A controlled trial of transcutaneous vagus nerve stimulation for the treatment of pharmacoresistant epilepsy. Epilepsy Behav. 2014;39:105–10.PubMedCrossRef
21.
22.
Clough RW, Neese SL, Sherill LK, Tan AA, Duke A, Roosevelt RW, Browning RA, Smith DC. Cortical edema in moderate fluid percussion brain injury is attenuated by vagus nerve stimulation. Neuroscience. 2007;147(2):286–93.PubMedCrossRef
23.
Neese SL, Sherill LK, Tan AA, Roosevelt RW, Browning RA, Smith DC, Duke A, Clough RW. Vagus nerve stimulation may protect GABAergic neurons following traumatic brain injury in rats: an immunocytochemical study. Brain Res. 2007;1128(1):157–63.PubMedPubMedCentralCrossRef
24.
Feeney DM, Sutton RL. Pharmacotherapy for recovery of function after brain injury. Crit Rev Neurobiol. 1987;3(2):135–97.PubMed
25.
Gladstone DJ, Black SE. Enhancing recovery after stroke with noradrenergic pharmacotherapy: a new frontier? Can J Neurol Sci. 2000;27(2):97–105.PubMed
26.
Boyeson MG, Feeney DM. Intraventricular norepinephrine facilitates motor recovery following sensorimotor cortex injury. Pharmacol Biochem Behav. 1990;35(3):497–501.PubMedCrossRef
27.
Sutton RL, Hovda DA, Feeney DM. Amphetamine accelerates recovery of locomotor function following bilateral frontal cortex ablation in cats. Behav Neurosci. 1989;103(4):837–41.PubMedCrossRef
28.
Boyeson MG. Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy. Stroke. 1996;27(11):2145–6.PubMed
29.
Boyeson MG, Callister TR, Cavazos JE. Biochemical and behavioral effects of a sensorimotor cortex injury in rats pretreated with the noradrenergic neurotoxin DSP-4. Behav Neurosci. 1992;106(6):964–73.PubMedCrossRef
30.
Sutton RL, Feeney DM. Alpha-noradrenergic agonists and antagonists affect recovery and maintenance of beam-walking ability after sensorimotor cortex ablation in the rat. Restor Neurol Neurosci. 1992;4(1):1–11.PubMed
31.
Groves DA, Brown VJ. Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects. Neurosci Biobehav Rev. 2005;29(3):493–500.PubMedCrossRef
32.
Krahl SE, Clark KB, Smith DC, Browning RA. Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia. 1998;39(7):709–14.PubMedCrossRef
33.
Naritoku DK, Terry WJ, Helfert RH. Regional induction of FOS immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Res. 1995;22(1):53–62.PubMedCrossRef
34.
Hassert DL, Miyashita T, Williams CL. The effects of peripheral vagal nerve stimulation at a memory-modulating intensity on norepinephrine output in the basolateral amygdala. Behav Neurosci. 2004;118(1):79–88.PubMedCrossRef
35.
Roosevelt RW, Smith DC, Clough RW, Jensen RA, Browning RA. Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the rat. Brain Res. 2006;1119(1):124–32.PubMedPubMedCentralCrossRef
36.
Di Gennaro JL, Mack CD, Malakouti A, Zimmerman JJ, Armstead W, Vavilala MS. Use and effect of vasopressors after pediatric traumatic brain injury. Dev Neurosci. 2010;32(5–6):420–30.PubMedPubMedCentral
37.
Hopkins WF, Johnston D. Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus. J Neurophysiol. 1988;59(2):667–87.PubMed
38.
Mueller D, Porter JT, Quirk GJ. Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction. J Neurosci. 2008;28(2):369–75.PubMedCrossRef
39.
Gavrilyuk V, Dello Russo C, Heneka MT, Pelligrino D, Weinberg G, Feinstein DL. Norepinephrine increases I kappa B alpha expression in astrocytes. J Biol Chem. 2002;277(33):29662–8.PubMedCrossRef
40.
Heneka MT, Nadrigny F, Regen T, Martinez-Hernandez A, Dumitrescu-Ozimek L, Terwel D, Jardanhazi-Kurutz D, Walter J, Kirchhoff F, Hanisch UK, et al. Locus ceruleus controls Alzheimer’s disease pathology by modulating microglial functions through norepinephrine. Proc Natl Acad Sci USA. 2010;107(13):6058–63.PubMedPubMedCentralCrossRef
41.
Clough RW, Browning RA, Maring ML, Statnick MA, Wang C, Jobe PC. Effects of intraventricular locus coeruleus transplants on seizure severity in genetically epilepsy-prone rats following depletion of brain norepinephrine. J Neural Transplant Plast. 1994;5(1):65–79.PubMedPubMedCentralCrossRef
42.
Weinshenker D, Szot P. The role of catecholamines in seizure susceptibility: new results using genetically engineered mice. Pharmacol Ther. 2002;94(3):213–33.PubMedCrossRef
43.
Rothwell N. Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav Immun. 2003;17(3):152–7.PubMedCrossRef
44.
Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405(6785):458–62.PubMedCrossRef
45.
Pavlov VA, Tracey KJ. The cholinergic anti-inflammatory pathway. Brain Behav Immun. 2005;19(6):493–9.PubMedCrossRef
46.
Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, Li JH, Yang H, Ulloa L, Al-Abed Y, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421(6921):384–8.PubMedCrossRef
47.
Raghupathi R. Cell death mechanisms following traumatic brain injury. Brain Pathol. 2004;14(2):215–22.PubMedCrossRef
48.
Ben-Menachem E, Hamberger A, Hedner T, Hammond EJ, Uthman BM, Slater J, Treig T, Stefan H, Ramsay RE, Wernicke JF, et al. Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures. Epilepsy Res. 1995;20(3):221–7.PubMedCrossRef
49.
Hammond EJ, Uthman BM, Wilder BJ, Ben-Menachem E, Hamberger A, Hedner T, Ekman R. Neurochemical effects of vagus nerve stimulation in humans. Brain Res. 1992;583(1–2):300–3.PubMedCrossRef
50.
Miyamoto O, Pang J, Sumitani K, Negi T, Hayashida Y, Itano T. Mechanisms of the anti-ischemic effect of vagus nerve stimulation in the gerbil hippocampus. NeuroReport. 2003;14(15):1971–4.PubMedCrossRef
51.
Asikainen I, Kaste M, Sarna S. Predicting late outcome for patients with traumatic brain injury referred to a rehabilitation programme: a study of 508 Finnish patients 5 years or more after injury. Brain Inj. 1998;12(2):95–107.PubMedCrossRef
52.
Pitkanen A, McIntosh TK. Animal models of post-traumatic epilepsy. J Neurotrauma. 2006;23(2):241–61.PubMedCrossRef
53.
Santhakumar V, Ratzliff AD, Jeng J, Toth Z, Soltesz I. Long-term hyperexcitability in the hippocampus after experimental head trauma. Ann Neurol. 2001;50(6):708–17.PubMedCrossRef
54.
Marrosu F, Serra A, Maleci A, Puligheddu M, Biggio G, Piga M. Correlation between GABA(A) receptor density and vagus nerve stimulation in individuals with drug-resistant partial epilepsy. Epilepsy Res. 2003;55(1–2):59–70.PubMedCrossRef
55.
Guerriero RM, Giza CC, Rotenberg A. Glutamate and GABA imbalance following traumatic brain injury. Curr Neurol Neurosci Rep. 2015;15(5):27.PubMedCrossRef
56.
Unterberg AW, Stover J, Kress B, Kiening KL. Edema and brain trauma. Neuroscience. 2004;129(4):1021–9.PubMedCrossRef
57.
McIntosh TK, Saatman KE, Raghupathi R, Graham DI, Smith DH, Lee VM, Trojanowski JQ. The Dorothy Russell Memorial Lecture. The molecular and cellular sequelae of experimental traumatic brain injury: pathogenetic mechanisms. Neuropathol Appl Neurobiol. 1998;24(4):251–67.PubMedCrossRef
58.
Marmarou A. Pathophysiology of traumatic brain edema: current concepts. Acta Neurochir Suppl. 2003;86:7–10.PubMed
59.
Bansal V, Costantini T, Kroll L, Peterson C, Loomis W, Eliceiri B, Baird A, Wolf P, Coimbra R. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. J Neurotrauma. 2009;26(8):1353–9.PubMedPubMedCentralCrossRef
60.
Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, Putnam J, Elicieri B, Baird A, Coimbra R. Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma. 2010;68(5):1059–64.PubMedPubMedCentralCrossRef
61.
62.
Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N, et al. Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. Biochem Biophys Res Commun. 2009;390(4):1121–5.PubMedCrossRef
63.
Lopez NE, Krzyzaniak MJ, Blow C, Putnam J, Ortiz-Pomales Y, Hageny AM, Eliceiri B, Coimbra R, Bansal V. Ghrelin prevents disruption of the blood-brain barrier after traumatic brain injury. J Neurotrauma. 2012;29(2):385–93.PubMedPubMedCentralCrossRef
64.
Candelario-Jalil E, Yang Y, Rosenberg GA. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience. 2009;158(3):983–94.PubMedPubMedCentralCrossRef
65.
Bansal V, Ryu SY, Lopez N, Allexan S, Krzyzaniak M, Eliceiri B, Baird A, Coimbra R. Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury. Inflammation. 2012;35(1):214–20.PubMedPubMedCentralCrossRef
66.
Cheyuo C, Wu R, Zhou M, Jacob A, Coppa G, Wang P. Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve. Shock. 2011;35(3):258–65.PubMedCrossRef
67.
Miao Y, Xia Q, Hou Z, Zheng Y, Pan H, Zhu S. Ghrelin protects cortical neuron against focal ischemia/reperfusion in rats. Biochem Biophys Res Commun. 2007;359(3):795–800.PubMedCrossRef
68.
Wu R, Dong W, Cui X, Zhou M, Simms HH, Ravikumar TS, Wang P. Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve. Ann Surg. 2007;245(3):480–6.PubMedPubMedCentralCrossRef
69.
Qi L, Cui X, Dong W, Barrera R, Coppa GF, Wang P, Wu R. Ghrelin protects rats against traumatic brain injury and hemorrhagic shock through upregulation of UCP2. Ann Surg. 2014;260(1):169–78.PubMedCrossRef
70.
Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology. 2002;123(4):1120–8.PubMedCrossRef
71.
Sato N, Kanai S, Takano S, Kurosawa M, Funakoshi A, Miyasaka K. Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats. Jpn J Physiol. 2003;53(6):443–9.PubMedCrossRef
72.
Shrestha YB, Wickwire K, Giraudo SQ. Direct effects of nutrients, acetylcholine, CCK, and insulin on ghrelin release from the isolated stomachs of rats. Peptides. 2009;30(6):1187–91.PubMedPubMedCentralCrossRef
73.
Yin X, Li Y, Xu G, An W, Zhang W. Ghrelin fluctuation, what determines its production? Acta Biochim Biophys Sin. 2009;41(3):188–97.PubMedCrossRef
74.
Grady MS, Jane JA, Steward O. Synaptic reorganization within the human central nervous system following injury. J Neurosurg. 1989;71(4):534–7.PubMedCrossRef
75.
76.
Revesz D, Tjernstrom M, Ben-Menachem E, Thorlin T. Effects of vagus nerve stimulation on rat hippocampal progenitor proliferation. Exp Neurol. 2008;214(2):259–65.PubMedCrossRef
77.
Helmy A, Vizcaychipi M, Gupta AK. Traumatic brain injury: intensive care management. Br J Anaesth. 2007;99(1):32–42.PubMedCrossRef
78.
Tubbs RS, Wellons JC 3rd, Blount JP, Oakes WJ. Left-sided vagus nerve stimulation decreases intracranial pressure without resultant bradycardia in the pig: a potential therapeutic modality for humans. Child’s Nerv Syst. 2004;20(5):309–12.CrossRef
79.
Pettorossi VE, Di Rocco C, Caldarelli M, Mancinelli R, Velardi F. Influences of phasic changes in systemic blood pressure on intracranial pressure. Eur Neurol. 1978;17(4):216–25.PubMedCrossRef
80.
George MS, Aston-Jones G. Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Neuropsychopharmacology. 2010;35(1):301–16.PubMedPubMedCentralCrossRef
81.
Ben-Menachem E. Vagus nerve stimulation, side effects, and long-term safety. J Clin Neurophysiol. 2001;18(5):415–8.PubMedCrossRef
82.
Annegers JF, Coan SP, Hauser WA, Leestma J. Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality, and sudden, unexpected, unexplained death. Epilepsia. 2000;41(5):549–53.PubMedCrossRef
83.
Silver JM, Koumaras B, Meng X, Potkin SG, Reyes PF, Harvey PD, Katz DI, Gunay I, Arciniegas DB. Long-term effects of rivastigmine capsules in patients with traumatic brain injury. Brain Inj. 2009;23(2):123–32.PubMedCrossRef
84.
Schiff ND, Giacino JT, Kalmar K, Victor JD, Baker K, Gerber M, Fritz B, Eisenberg B, Biondi T, O’Connor J, et al. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature. 2007;448(7153):600–3.PubMedCrossRef
85.
Yamamoto T, Katayama Y. Deep brain stimulation therapy for the vegetative state. Neuropsychol Rehabil. 2005;15(3–4):406–13.PubMedCrossRef
86.
Lee DJ, Gurkoff GG, Izadi A, Berman RF, Ekstrom AD, Muizelaar JP, Lyeth BG, Shahlaie K. Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory after traumatic brain injury. J Neurotrauma. 2013;30(2):131–9.PubMedCrossRef
87.
Carballosa Gonzalez MM, Blaya MO, Alonso OF, Bramlett HM, Hentall ID. Midbrain raphe stimulation improves behavioral and anatomical recovery from fluid-percussion brain injury. J Neurotrauma. 2013;30(2):119–30.PubMedPubMedCentralCrossRef
88.
Shin SS, Dixon CE, Okonkwo DO, Richardson RM. Neurostimulation for traumatic brain injury. J Neurosurg. 2014;121(5):1219–31.PubMedCrossRef
89.
Hoge CW, McGurk D, Thomas JL, Cox AL, Engel CC, Castro CA. Mild traumatic brain injury in U.S. Soldiers returning from Iraq. N Engl J Med. 2008;358(5):453–63.PubMedCrossRef
90.
Divani AA, Murphy AJ, Meints J, Sadeghi-Bazargani H, Nordberg J, Monga M, Low WC, Bhatia PM, Beilman GJ, SantaCruz KS. A novel preclinical model of moderate primary blast-induced traumatic brain injury. J Neurotrauma. 2015;32(14):1109–16.PubMedCrossRef
91.
Luethcke CA, Bryan CJ, Morrow CE, Isler WC. Comparison of concussive symptoms, cognitive performance, and psychological symptoms between acute blast-versus nonblast-induced mild traumatic brain injury. J Int Neuropsychol Soc. 2011;17(1):36–45.PubMedCrossRef
92.
Langevin JP, De Salles AA, Kosoyan HP, Krahl SE. Deep brain stimulation of the amygdala alleviates post-traumatic stress disorder symptoms in a rat model. J Psychiatr Res. 2010;44(16):1241–5.PubMedCrossRef
93.
Villamar MF, Santos Portilla A, Fregni F, Zafonte R. Noninvasive brain stimulation to modulate neuroplasticity in traumatic brain injury. Neuromodulation. 2012;15(4):326–38.PubMedCrossRef
94.
Hsu WY, Cheng CH, Liao KK, Lee IH, Lin YY. Effects of repetitive transcranial magnetic stimulation on motor functions in patients with stroke: a meta-analysis. Stroke. 2012;43(7):1849–57.PubMedCrossRef
95.
Elahi B, Chen R. Effect of transcranial magnetic stimulation on Parkinson motor function: systematic review of controlled clinical trials. Mov Disord. 2009;24(3):357–63.PubMedCrossRef
96.
Yoon YS, Cho KH, Kim ES, Lee MS, Lee KJ. Effect of epidural electrical stimulation and repetitive transcranial magnetic stimulation in rats with diffuse traumatic brain injury. Ann Rehabil Med. 2015;39(3):416–24.PubMedPubMedCentralCrossRef
97.
Koski L, Kolivakis T, Yu C, Chen JK, Delaney S, Ptito A. Noninvasive brain stimulation for persistent postconcussion symptoms in mild traumatic brain injury. J Neurotrauma. 2015;32(1):38–44.PubMedCrossRef
98.
Louise-Bender Pape T, Rosenow J, Lewis G, Ahmed G, Walker M, Guernon A, Roth H, Patil V. Repetitive transcranial magnetic stimulation-associated neurobehavioral gains during coma recovery. Brain Stimul. 2009;2(1):22–35.PubMedCrossRef
99.
Pachalska M, Lukowicz M, Kropotov JD, Herman-Sucharska I, Talar J. Evaluation of differentiated neurotherapy programs for a patient after severe TBI and long term coma using event-related potentials. Med Sci Monit. 2011;17(10):CS120–8.PubMedPubMedCentralCrossRef
100.
Nielson DM, McKnight CA, Patel RN, Kalnin AJ, Mysiw WJ. Preliminary guidelines for safe and effective use of repetitive transcranial magnetic stimulation in moderate to severe traumatic brain injury. Arch Phys Med Rehabil. 2015;96(4):S138–44.PubMedCrossRef
101.
Fitzgerald PB, Hoy KE, Maller JJ, Herring S, Segrave R, McQueen S, Peachey A, Hollander Y, Anderson JF, Daskalakis ZJ. Transcranial magnetic stimulation for depression after a traumatic brain injury: a case study. J ECT. 2011;27(1):38–40.PubMedCrossRef
102.
Opitz A, Paulus W, Will S, Antunes A, Thielscher A. Determinants of the electric field during transcranial direct current stimulation. NeuroImage. 2015;109:140–50.PubMedCrossRef
103.
Gomez Palacio Schjetnan A, Faraji J, Metz GA, Tatsuno M, Luczak A. Transcranial direct current stimulation in stroke rehabilitation: a review of recent advancements. Stroke Res Treat. 2013;2013:170256.PubMedPubMedCentral
104.
Luedtke K, Rushton A, Wright C, Geiss B, Juergens TP, May A. Transcranial direct current stimulation for the reduction of clinical and experimentally induced pain: a systematic review and meta-analysis. Clin J Pain. 2012;28(5):452–61.PubMedCrossRef
105.
Jacobson L, Koslowsky M, Lavidor M. tDCS polarity effects in motor and cognitive domains: a meta-analytical review. Exp Brain Res. 2012;216(1):1–10.PubMedCrossRef
106.
Kang EK, Kim DY, Paik NJ. Transcranial direct current stimulation of the left prefrontal cortex improves attention in patients with traumatic brain injury: a pilot study. J Rehabil Med. 2012;44(4):346–50.PubMedCrossRef
107.
Li S, Zaninotto AL, Neville IS, Paiva WS, Nunn D, Fregni F. Clinical utility of brain stimulation modalities following traumatic brain injury: current evidence. Neuropsychiatr Dis Treat. 2015;11:1573–86.PubMedPubMedCentral
108.
Ulam F, Shelton C, Richards L, Davis L, Hunter B, Fregni F, Higgins K. Cumulative effects of transcranial direct current stimulation on EEG oscillations and attention/working memory during subacute neurorehabilitation of traumatic brain injury. Clin Neurophysiol. 2015;126(3):486–96.PubMedCrossRef
109.
Elias WJ, Huss D, Voss T, Loomba J, Khaled M, Zadicario E, Frysinger RC, Sperling SA, Wylie S, Monteith SJ, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med. 2013;369(7):640–8.PubMedCrossRef
110.
Mihran RT, Barnes FS, Wachtel H. Transient modification of nerve excitability in vitro by single ultrasound pulses. Biomed Sci Instrum. 1990;26:235–46.PubMed
111.
Tsui PH, Wang SH, Huang CC. In vitro effects of ultrasound with different energies on the conduction properties of neural tissue. Ultrasonics. 2005;43(7):560–5.PubMedCrossRef
112.
Juan EJ, Gonzalez R, Albors G, Ward MP, Irazoqui P. Vagus nerve modulation using focused pulsed ultrasound: potential applications and preliminary observations in a rat. Int J Imaging Syst Technol. 2014;24(1):67–71.PubMedPubMedCentralCrossRef
113.
Legon W, Rowlands A, Opitz A, Sato TF, Tyler WJ. Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI. PLoS One. 2012;7(12):e51177.PubMedPubMedCentralCrossRef
114.
Tufail Y, Matyushov A, Baldwin N, Tauchmann ML, Georges J, Yoshihiro A, Tillery SI, Tyler WJ. Transcranial pulsed ultrasound stimulates intact brain circuits. Neuron. 2010;66(5):681–94.PubMedCrossRef
115.
Yoo SS, Bystritsky A, Lee JH, Zhang Y, Fischer K, Min BK, McDannold NJ, Pascual-Leone A, Jolesz FA. Focused ultrasound modulates region-specific brain activity. NeuroImage. 2011;56(3):1267–75.PubMedPubMedCentralCrossRef
116.
Deffieux T, Younan Y, Wattiez N, Tanter M, Pouget P, Aubry JF. Low-intensity focused ultrasound modulates monkey visuomotor behavior. Curr Biol. 2013;23(23):2430–3.PubMedCrossRef
117.
Legon W, Sato TF, Opitz A, Mueller J, Barbour A, Williams A, Tyler WJ. Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans. Nat Neurosci. 2014;17(2):322–9.PubMedCrossRef
118.
Mueller J, Legon W, Opitz A, Sato TF, Tyler WJ. Transcranial focused ultrasound modulates intrinsic and evoked EEG dynamics. Brain Stimul. 2014;7(6):900–8.PubMedCrossRef
119.
Skolnick BE, Maas AI, Narayan RK, van der Hoop RG, MacAllister T, Ward JD, Nelson NR, Stocchetti N. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med. 2014;371(26):2467–76.PubMedCrossRef
120.
Wright DW, Yeatts SD, Silbergleit R, Palesch YY, Hertzberg VS, Frankel M, Goldstein FC, Caveney AF, Howlett-Smith H, Bengelink EM, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371(26):2457–66.PubMedPubMedCentralCrossRef
Metadaten
Titel
Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury
verfasst von
Daniel Neren
Matthew D. Johnson
Wynn Legon
Salam P. Bachour
Geoffrey Ling
Afshin A. Divani
Publikationsdatum
23.09.2015
Verlag
Springer US
Erschienen in
Neurocritical Care / Ausgabe 2/2016
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-015-0203-0

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