In newborns and children, body fat estimation equations are often used at different ages than the age used to develop the equations. Limited validation studies exist for newborn body fat estimation equations at birth or later in infancy. The study purpose was to validate 4 newborn fat mass (FM) estimation equations in comparison to FM measured by air displacement plethysmography (ADP; the Pea Pod) at birth and 3 months.
Ninety-five newborns (1–3 days) had their body composition measured by ADP and anthropometrics assessed by skinfolds. Sixty-three infants had repeat measures taken (3 months). FM measured by ADP was compared to FM from the skinfold estimation equations (Deierlein, Catalano, Lingwood, and Aris). Paired t-tests assessed mean differences, linear regression assessed accuracy, precision was assessed by R2 and standard error of the estimate (SEE), and bias was assessed by Bland-Altman plots.
At birth, FM measured by ADP differed from FM estimated by Deierlein, Lingwood and Aris equations, but did not differ from the Catalano equation. At 3 months, FM measured by ADP was different from all equations. At both time points, poor precision and accuracy was detected. Bias was detected in most all equations.
Poor agreement, precision, and accuracy were found between prediction equations and the criterion at birth and 3 months.
Brunner S, Schmid D, Huttinger K, Much D, Heimberg E, Sedlmeier EM, Bruderl M, Kratzsch J, Bader BL, Amann-Gassner U, Hauner H. Maternal insulin resistance, triglycerides and cord blood insulin in relation to post-natal weight trajectories and body composition in the offspring up to 2 years. Diabet Med. 2013;30:1500–7. CrossRefPubMed
Catalano PM, Mele L, Landon MB, Ramin SM, Reddy UM, Casey B, Wapner RJ, Varner MW, Rouse DJ, Thorp Jr JM, Saade G, Sorokin Y, Peaceman AM, Tolosa JE. Inadequate weight gain in overweight and obese pregnant women: what is the effect on fetal growth? Am J Obstet Gynecol. 2014;211:137. e1-7. CrossRefPubMedPubMedCentral
Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Sedlmeier EM, Heimberg E, Schuster T, Zimmermann A, Schneider KT, Bader BL, Amann-Gassner U. Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. Am J Clin Nutr. 2012;95:383–94. CrossRefPubMed
Naf S, Escote X, Ballesteros M, Yanez RE, Simon-Muela I, Gil P, Albaiges G, Vendrell J, Megia A. Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring. PLoS One. 2014;9:e92175. CrossRefPubMedPubMedCentral
Badon SE, Dyer AR, Josefson JL, HAPO Study Cooperative Research Group. Gestational weight gain and neonatal adiposity in the Hyperglycemia and Adverse Pregnancy Outcome study-North American region. Obesity (Silver Spring). 2014;22(7):1731–8.
Lingwood BE, van Leeuwen AMS, Carberry AE, Fitzgerald EC, Callaway LK, Colditz PB, Ward LC. Prediction of fat-free mass and percentage of body fat in neonates using bioelectrical impedance analysis and anthropometric measures: validation against the PEA POD. Br J Nutr. 2012;107:1545–52. CrossRefPubMed
Penalvo JL, Santos-Beneit G, Sotos-Prieto M, Martinez R, Rodriguez C, Franco M, Lopez-Romero P, Pocock S, Redondo J, Fuster V. A cluster randomized trial to evaluate the efficacy of a school-based behavioral intervention for health promotion among children aged 3 to 5. BMC Public Health. 2013;13:656. CrossRefPubMedPubMedCentral
Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, Bemben DA. Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1988;60:709–23. PubMed
Schmelzle HR, Fusch C. Body fat in neonates and young infants: validation of skinfold thickness versus dual-energy X-ray absorptiometry. Am J Clin Nutr. 2002;76:1096–100. PubMed
Goran MI, Driscoll P, Johnson R, Nagy TR, Hunter G. Cross-calibration of body-composition techniques against dual-energy X-ray absorptiometry in young children. Am J Clin Nutr. 1996;63:299–305. PubMed
Weststrate JA, Deurenberg P. Body composition in children: proposal for a method for calculating body fat percentage from total body density or skinfold-thickness measurements. Am J Clin Nutr. 1989;50:1104–15. PubMed
Deierlein AL, Thornton J, Hull H, Paley C, Gallagher D. An anthropometric model to estimate neonatal fat mass using air displacement plethysmography. Nutr Metab (Lond). 2012;9.
Fomon SJ, Haschke F, Ziegler EE, Nelson SE. Body composition of reference children from birth to age 10 years. Am J Clin Nutr. 1982;35:1169–75. PubMed
Ma G, Yao M, Liu Y, Lin A, Zou H, Urlando A, Wong WW, Nommsen-Rivers L, Dewey KG. Validation of a new pediatric air-displacement plethysmograph for assessing body composition in infants. Am J Clin Nutr. 2004;79:653–60. PubMed
Lohman TG. Advances in body compsoition assessment: current issues in exercise sciences series. Champaign: Human Kinetics; 1992.
de Bruin NC, van Velthoven KA, Stijnen T, Juttmann RE, Degenhart HJ, Visser HK. Body fat and fat-free mass in infants: new and classic anthropometric indexes and prediction equations compared with total-body electrical conductivity. Am J Clin Nutr. 1995;61:1195–205. PubMed
McFarland MB, Trylovich CG, Langer O. Anthropometric differences in macrosomic infants of diabetic and nondiabetic mothers. J Matern Fetal Med. 1998;7:292–5. PubMed
Paley C, H Hull, Y Ji, T Toro-Ramos, J Thornton, J Bauer, P Matthews, A Yu, K Navder, K Dorsey, and D Gallagher. Body fat differences by self-reported race/ethnicity in healthy term newborns . Pediatr Obes. 2015. doi: 10.1111/ijpo.12072. [Epub ahead of print].
- Validity of anthropometric equations to estimate infant fat mass at birth and in early infancy
Jennifer S. Cauble
Holly R. Hull
- BioMed Central
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