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Diabetologia

Erschienen in:

14.08.2019 | Review

VEGF-A and blood vessels: a beta cell perspective

verfasst von: Willem Staels, Yves Heremans, Harry Heimberg, Nico De Leu

Erschienen in: Diabetologia | Ausgabe 11/2019

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Abstract

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult pancreas, islets depend on their dense capillary network to adequately respond to changes in plasma glucose levels. Vascular changes contribute to the onset and progression of both type 1 and type 2 diabetes. Impaired revascularisation of islets transplanted in individuals with type 1 diabetes is linked to islet graft failure and graft loss. This review summarises our understanding of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell development, physiology and disease. In addition, the therapeutic potential of modulating VEGF-A levels in beta and beta-like cells for transplantation is discussed.

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Titel: VEGF-A and blood vessels: a beta cell perspective
verfasst von: Willem Staels
Yves Heremans
Harry Heimberg
Nico De Leu
Publikationsdatum: 14.08.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Diabetologia / Ausgabe 11/2019
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-019-4969-z

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