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06.11.2019 | Originalien

Vitamin E-blended versus conventional polyethylene liners in prostheses

Prospective, randomized trial with 3-year follow-up

verfasst von: Dr. André Busch, Marcus Jäger, Alexander Wegner, Marcel Haversath, VITAS group

Erschienen in: Die Orthopädie | Ausgabe 12/2020

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Abstract

Background

Despite continuous technical improvements, polyethylene wear debris induced periprosthetic osteolysis remains the main cause for failure of hip arthroplasty. Progressive oxidation of polyethylene was identified as another risk factor for material failure. To overcome this problem, antioxidants such as vitamin E (alpha-tocopherol) were supplemented by diffusion into the latest generation of polyethylene liners.

Objective

The purpose of the present study was to investigate the clinical outcome of patients treated with vitamin E blended highly cross-linked ultra-high molecular weight polyethylene liners (UHMWPE-XE) in comparison with conventional UHMWPE‑X liners by evaluating patient-reported outcome measures (PROM’s) at 3‑year follow-up.

Methods

A total of 143 patients were recruited into this prospective, randomized trial in our academic center. Three years after implantation, 101 patients were examined in the outpatient clinic for follow-up. Of these, 51 (50.5%) received UHMWPE-XE and 50 (49.5%) UHMWPE‑X liners. Clinical outcome was evaluated using Harris-Hip-Score (HHS) UCLA-Score and Hip Disability and Osteoarthritis Outcome Score (HOOS).

Results

There was a significant improvement in all PROM’s at one- and three-year follow-up compared to the status before implantation. PROM’s did not differ significantly between the first and third year follow-up. Both liner groups showed an equal clinical outcome.

Conclusion

The present study demonstrates that the supplementation of vitamin E to polyethylene liners is reliable and safe without showing higher complication rates compared with conventional polyethylene liners. The shortterm clinical outcome of vitamin E-blended (UHMWPE‑XE) is equivalent to those of conventional highly cross-linked polyethylene liners.

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Titel: Vitamin E-blended versus conventional polyethylene liners in prostheses
Prospective, randomized trial with 3-year follow-up
verfasst von: Dr. André Busch
Marcus Jäger
Alexander Wegner
Marcel Haversath
VITAS group
Publikationsdatum: 06.11.2019
Verlag: Springer Medizin
Erschienen in: Die Orthopädie / Ausgabe 12/2020
Print ISSN: 2731-7145
Elektronische ISSN: 2731-7153
DOI: https://doi.org/10.1007/s00132-019-03830-6

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