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Erschienen in:
01.12.2019 | Chronic Myeloid Leukemias (G Saglio, Section Editor)
What Does Chronic Myeloid Leukaemia Tell Us About Other Leukaemias?
Erschienen in: Current Hematologic Malignancy Reports | Ausgabe 6/2019
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Purpose of Review
Determine if therapy of chronic myeloid leukaemia (CML) is a model for treating other cancers.
Recent Findings
CML has a relatively homogeneous phenotype and genotype and is caused by one mutation, BCRABL1, in every instance. In contrast, most other leukaemias, haematologic cancers and solid cancer have more heterogeneous phenotypes and extraordinarily greater genotypic diversity and mutational complexity.
Summary
Lesions learned from treating CML have little applicability to other leukaemias, haematologic cancers or solid cancer.