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Current Dermatology Reports

Erschienen in:

16.04.2018 | Skin Cancer (A Marghoob and M Marchetti, Section Editors)

What Is New in CTCL—Pathogenesis, Diagnosis, and Treatments

verfasst von: Brittany O. Dulmage, Betty Y. Kong, Kassandra Holzem, Joan Guitart

Erschienen in: Current Dermatology Reports | Ausgabe 2/2018

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Abstract

Purpose of Review

Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin’s lymphoma primarily affecting the skin, of which mycosis fungoides (MF) and Sézary syndrome (SS) account for the majority of cases. The pathogenesis of CTCL is poorly understood with no strongly associated environmental or genetic risk factors identified to date. As such, the development of disease-specific therapies has been limited by a lack of understanding of potentially actionable targets. Moreover, the diagnosis of CTCL remains challenging with nonspecific diagnostic criteria, especially in early-stage disease.

Recent Findings

The advent of high-throughput sequencing techniques and molecular modalities has provided significant insight into disease pathogenesis, diagnosis, and potential therapies.

Summary

Here, we review the classic features of CTCL, focusing on MF/SS, and provide updates on our understanding of this disease.

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Titel: What Is New in CTCL—Pathogenesis, Diagnosis, and Treatments
verfasst von: Brittany O. Dulmage
Betty Y. Kong
Kassandra Holzem
Joan Guitart
Publikationsdatum: 16.04.2018
Verlag: Springer US
Erschienen in: Current Dermatology Reports / Ausgabe 2/2018
Elektronische ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-018-0214-0

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