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European Radiology
Erschienen in: European Radiology 4/2018

23.10.2017 | Gastrointestinal

Whole-tumour diffusion kurtosis MR imaging histogram analysis of rectal adenocarcinoma: Correlation with clinical pathologic prognostic factors

verfasst von: Yanfen Cui, Xiaotang Yang, Xiaosong Du, Zhizheng Zhuo, Lei Xin, Xintao Cheng

Erschienen in: European Radiology | Ausgabe 4/2018

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Abstract

Objective

To investigate potential relationships between diffusion kurtosis imaging (DKI)-derived parameters using whole-tumour volume histogram analysis and clinicopathological prognostic factors in patients with rectal adenocarcinoma.

Material and methods

79 consecutive patients who underwent MRI examination with rectal adenocarcinoma were retrospectively evaluated. Parameters D, K and conventional ADC were measured using whole-tumour volume histogram analysis. Student’s t-test or Mann-Whitney U-test, receiver operating characteristic curves and Spearman’s correlation were used for statistical analysis.

Results

Almost all the percentile metrics of K were correlated positively with nodal involvement, higher histological grades, the presence of lymphangiovascular invasion (LVI) and circumferential margin (CRM) (p<0.05), with the exception of between K10th, K90th and histological grades. In contrast, significant negative correlations were observed between 25th, 50th percentiles and mean values of ADC and D, as well as ADC10th, with tumour T stages (p< 0.05). Meanwhile, lower 75th and 90th percentiles of ADC and D values were also correlated inversely with nodal involvement (p< 0.05). Kmean showed a relatively higher area under the curve (AUC) and higher specificity than other percentiles for differentiation of lesions with nodal involvement.

Conclusion

DKI metrics with whole-tumour volume histogram analysis, especially K parameters, were associated with important prognostic factors of rectal cancer.

Key Points

• K correlated positively with some important prognostic factors of rectal cancer.
• K mean showed higher AUC and specificity for differentiation of nodal involvement.
• DKI metrics with whole-tumour volume histogram analysis depicted tumour heterogeneity.
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Metadaten
Titel
Whole-tumour diffusion kurtosis MR imaging histogram analysis of rectal adenocarcinoma: Correlation with clinical pathologic prognostic factors
verfasst von
Yanfen Cui
Xiaotang Yang
Xiaosong Du
Zhizheng Zhuo
Lei Xin
Xintao Cheng
Publikationsdatum
23.10.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 4/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5094-3

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