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01.11.2014 | Magnetic Resonance

Simple measurements on diffusion-weighted MR imaging for assessment of complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

verfasst von: Pei-Qiang Cai, Yao-Pan Wu, Xin An, Xue Qiu, Ling-Heng Kong, Guo-Chen Liu, Chuan-Miao Xie, Zhi-Zhong Pan, Pei-Hong Wu, Pei-Rong Ding

Erschienen in: European Radiology | Ausgabe 11/2014

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Abstract

Purpose

To determine diagnostic performance of simple measurements on diffusion-weighted MR imaging (DWI) for assessment of complete tumour response (CR) after neoadjuvant chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC) by signal intensity (SI) and apparent diffusion coefficient (ADC) measurements.

Materials and methods

Sixty-five patients with LARC who underwent neoadjuvant CRT and subsequent surgery were included. Patients underwent pre-CRT and post-CRT 3.0 T MRI. Regions of interest of the highest brightness SI were included in the tumour volume on post-CRT DWI to calculate the SI_lesion, rSI, ADC_lesion and rADC; diagnostic performance was compared by using the receiver operating characteristic (ROC) curves. In order to validate the accuracy and reproducibility of the current strategy, the same procedure was reproduced in 80 patients with LARC at 1.5 T MRI.

Results

Areas under the ROC curve for identification of a CR, based on SI_lesion, rSI, ADC_lesion, and rADC, respectively, were 0.86, 0.94, 0.66, and 0.71 at 3.0 T MRI, and 0.92, 0.91, 0.64, and 0.61 at 1.5 T MRI.

Conclusion

Post-CRT DWI SI_lesion and rSI provided high diagnostic performance in assessing CR and were significantly more accurate than ADC_lesion, and rADC at 3.0 T MRI and 1.5 T MRI.

Key Points

• Signal intensity (SI _lesion) and rSI are accurate for assessment of complete response.

• rSI seems to be superior to SI _lesion at 3.0 T MRI.

• ADC or rADC measurements are not accurate for assessment of complete response.

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Titel: Simple measurements on diffusion-weighted MR imaging for assessment of complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
verfasst von: Pei-Qiang Cai
Yao-Pan Wu
Xin An
Xue Qiu
Ling-Heng Kong
Guo-Chen Liu
Chuan-Miao Xie
Zhi-Zhong Pan
Pei-Hong Wu
Pei-Rong Ding
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 11/2014
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3251-5

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Simple measurements on diffusion-weighted MR imaging for assessment of complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer