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Indian Journal of Hematology and Blood Transfusion

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01.06.2016 | Review Article

Wnt Signaling: Role in Regulation of Haematopoiesis

verfasst von: Ram Babu Undi, Usha Gutti, Itishri Sahu, Shilpa Sarvothaman, Satya Ratan Pasupuleti, Ravinder Kandi, Ravi Kumar Gutti

Erschienen in: Indian Journal of Hematology and Blood Transfusion | Ausgabe 2/2016

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Abstract

Hematopoietic stem cells (HSCs) are a unique population of bone marrow cells which are responsible for the generation of various blood cell lineages. One of the significant characteristics of these HSCs is to self-renew, while producing differentiating cells for normal hematopoiesis. Deregulation of self-renewal and differentiation leads to the hematological malignancies. Several pathways are known to be involved in the maintenance of HSC fate among which Wnt signaling is a crucial pathway which controls development and cell fate determination. Wnt signaling also plays a major role in differentiation, self-renewal and maintenance of HSCs. Wnt ligands activate three major pathways including planar cell polarity, Wnt/β-catenin and Wnt/Ca²⁺. It has been shown that Wnt/β-catenin or canonical pathway regulates cell proliferation, survival and differentiation in HSCs, deregulation of this pathway leads to hematological malignancies. Wnt non-canonical pathway regulates calcium signaling and planar cell polarity. In this review, we discuss various signaling pathways induced by Wnt ligands and their potential role in hematopoiesis.

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Titel: Wnt Signaling: Role in Regulation of Haematopoiesis
verfasst von: Ram Babu Undi
Usha Gutti
Itishri Sahu
Shilpa Sarvothaman
Satya Ratan Pasupuleti
Ravinder Kandi
Ravi Kumar Gutti
Publikationsdatum: 01.06.2016
Verlag: Springer India
Erschienen in: Indian Journal of Hematology and Blood Transfusion / Ausgabe 2/2016
Print ISSN: 0971-4502
Elektronische ISSN: 0974-0449
DOI: https://doi.org/10.1007/s12288-015-0585-3

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Springer Medizin

Wnt Signaling: Role in Regulation of Haematopoiesis

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