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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

29.10.2018 | Original Article

Yttrium-90 glass microspheres radioembolization (RE) for biliary tract cancer: a large single-center experience

verfasst von: Héloïse Bourien, Xavier Palard, Yan Rolland, Fanny Le Du, Luc Beuzit, Thomas Uguen, Samuel Le Sourd, Marc Pracht, Vincent Manceau, Astrid Lièvre, Karim Boudjema, Etienne Garin, Julien Edeline

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 3/2019

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Abstract

Purpose

Radioembolization (RE) is a promising treatment option for biliary tract cancers (BTC). We report here the largest series to date using this treatment modality.

Methods

We retrospectively studied data from 64 patients treated outside prospective clinical trial at our institution. We studied baseline characteristics as potential prognostic factors. We studied dose delivered to the tumor as predictive factors of outcomes in patients not receiving concomitant chemotherapy.

Results

The Progression-Free Survival and Overall Survival (OS) were 7.6 months [95% Confidence Interval (CI): 4.6–10.6] and 16.4 months [95% CI: 7.8–25.0] in the whole cohort. The factors independently associated with OS in multivariable analysis were the primary localization of ICC (HR = 0.27, 95% CI: 0.11–0.68, p = 0.005) and a PS > 0 (HR = 2.21, 95% CI: 1.11–4.38, p = 0.024). During follow-up, 12 patients (19%) underwent surgery following downstaging, with a median OS of 51.9 months. In patients not treated with concomitant chemotherapy (n = 31), OS was significantly higher in patients with a dose delivered to the tumor 260Gy or higher than in patients with a dose delivered to the tumor lower than 260Gy (median 28.2 vs 11.4 months, log-rank p = 0.019).

Conclusion

Our results confirm that RE is a promising treatment modality in BTC. A high proportion of patients could be downstaged to surgery, with promising long-term survival. Dose delivered to the tumor correlated with clinical outcomes when chemotherapy was not used concomitantly.

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Titel: Yttrium-90 glass microspheres radioembolization (RE) for biliary tract cancer: a large single-center experience
verfasst von: Héloïse Bourien
Xavier Palard
Yan Rolland
Fanny Le Du
Luc Beuzit
Thomas Uguen
Samuel Le Sourd
Marc Pracht
Vincent Manceau
Astrid Lièvre
Karim Boudjema
Etienne Garin
Julien Edeline
Publikationsdatum: 29.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 3/2019
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-018-4199-5

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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