nach oben

European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

01.10.2008 | ORIGINAL PAPER

5-ht2c receptor and mao-a interaction analysis: no association with suicidal behaviour in bipolar patients

verfasst von: Vincenzo De Luca, Subi Tharmaligam, John Strauss, James L. Kennedy

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 7/2008

Einloggen, um Zugang zu erhalten

Abstract

The serotonin 2C (HTR2C) receptor has been implicated in suicide-related behaviours, however there are not many studies to date about HTR2C and suicidality. We studied HTR2C haplotypes in suicide attempters, where our sample composed of 306 families with at least one member affected by bipolar disorder. HTR2C (Cys23Ser and a common STR in the promoter) variants were analyzed with respect to attempter status and the severity of suicidal behaviour. The X-linked haplotype analysis in relation to suicide attempt did not reveal any significant association. Furthermore, we performed a particular gene-gene interaction for the X-linked serotonergic genes (HTR2C and MAOA), and found no association among this intergenic haplotype combination and suicidal behaviour in bipolar disorder.

APA (1994) Diagnostic and statistical manual of mental disorders, 4th edn (DSM-IV). APA, Washington, DC

Arango V, Ernsberger P, Marzuk PM, Chen JS, Tierney H, Stanley M, Reis DJ, Mann JJ (1990) Autoradiographic demonstration of increased serotonin 5-HT2 and beta-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry 47:1038–1047PubMed

Asberg M, Traskman L, Thoren P (1976) 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33:1193–1197PubMed

Canetto SS, Sakinofsky I (1998) The gender paradox in suicide. Suicide Life Threat Behav 28:1–23PubMed

Chen YW, Dilsaver SC (1996) Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biol Psychiatry 39:896–899PubMedCrossRef

Dalton EJ, Cate-Carter TD, Mundo E, Parikh SV, Kennedy JL (2003) Suicide risk in bipolar patients: the role of co-morbid substance use disorders. Bipolar Disord 5:58–61PubMedCrossRef

De Luca V, Tharmalingam S, Sicard T, Kennedy JL (2005) Gene-gene interaction between MAOA and COMT in suicidal behavior. Neurosci Lett 383:151–154PubMedCrossRef

De Luca V, Wang H, Squassina A, Wong GW, Yeomans J, Kennedy JL (2004) Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia. Neuropsychobiology 50:124–127PubMedCrossRef

Deckert J, Meyer J, Catalano M, Bosi M, Sand P, DiBella D, Ortega G, Stober G, Franke P, Nothen MM, Fritze J, Maier W, Beckmann H, Propping P, Bellodi L, Lesch KP (2000) Novel 5′-regulatory region polymorphisms of the 5-HT2C receptor gene: association study with panic disorder. Int J Neuropsychopharmacol 3:321–325PubMedCrossRef

10.

Drysdale CM, McGraw DW, Stack CB, Stephens JC, Judson RS, Nandabalan K, Arnold K, Ruano G, Liggett SB (2000) Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 97:10483–10488PubMedCrossRef

11.

Du L, Faludi G, Palkovits M, Sotonyi P, Bakish D, Hrdina PD (2002) High activity-related allele of MAO-A gene associated with depressed suicide in males. Neuroreport 13:1195–1198PubMedCrossRef

12.

Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115–121PubMedCrossRef

13.

Gutierrez B, Arias B, Papiol S, Rosa A, Fananas L (2001) Association study between novel promoter variants at the 5-HT2C receptor gene and human patients with bipolar affective disorder. Neurosci Lett 309:135–137PubMedCrossRef

14.

Jamison KR (2000) Suicide and bipolar disorder. J Clin Psychiatry 61(Suppl 9):47–51PubMed

15.

Joiner TE Jr, Brown JS, Wingate LR (2005) The psychology and neurobiology of suicidal behavior. Annu Rev Psychol 56:287–314PubMedCrossRef

16.

Lahiri DK, Nurnberger JI Jr (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444PubMedCrossRef

17.

Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D (1995) Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics 27:274–279PubMedCrossRef

18.

Mann JJ (1995) The fourth generation of progress. Raven Press, New York

19.

Mann JJ (1998) The neurobiology of suicide. Nat Med 4:25–30PubMedCrossRef

20.

Mann JJ, Brent DA, Arango V (2001) The neurobiology and genetics of suicide and attempted suicide: a focus on the serotonergic system. Neuropsychopharmacology 24:467–477PubMedCrossRef

21.

McGuffin P, Marusic A, Farmer A (2001) What can psychiatric genetics offer suicidology? Crisis 22:61–65PubMed

22.

Niswender CM, Herrick-Davis K, Dilley GE, Meltzer HY, Overholser JC, Stockmeier CA, Emeson RB, Sanders-Bush E (2001) RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy. Neuropsychopharmacology 24:478–491PubMedCrossRef

23.

Nordstrom P, Samuelsson M, Asberg M, Traskman-Bendz L, Aberg-Wistedt A, Nordin C, Bertilsson L (1994) CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life Threat Behav 24:1–9PubMed

24.

Okada M, Northup JK, Ozaki N, Russell JT, Linnoila M, Goldman D (2004) Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution. Mol Psychiatry 9:55–64PubMedCrossRef

25.

Pooley EC, Houston K, Hawton K, Harrison PJ (2003) Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other serotonergic genes. Psychol Med 33:775–783PubMedCrossRef

26.

Roy A (1993) Genetic and biologic risk factors for suicide in depressive disorders. Psychiatr Q 64:345–358PubMedCrossRef

27.

Rydin E, Asberg M, Edman G, Schalling D (1990) Violent and nonviolent suicide attempts–a controlled Rorschach study. Acta Psychiatr Scand 82:30–39PubMedCrossRef

28.

Serretti A, Mandelli L, Giegling I, Schneider B, Hartmann AM, Schnabel A, Maurer K, Moller HJ, Rujescu D (2007) HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers. Am J Med Genet B Neuropsychiatr Genet 144:291–299

29.

Sherif F, Marcusson J, Oreland L (1991) Brain gamma-aminobutyrate transaminase and monoamine oxidase activities in suicide victims. Eur Arch Psychiatry Clin Neurosci 241:139–144PubMedCrossRef

30.

Stack S (2000) Suicide: a 15-year review of the sociological literature. Part I: cultural and economic factors. Suicide Life Threat Behav 30:145–162PubMed

31.

Stefulj J, Buttner A, Kubat M, Zill P, Balija M, Eisenmenger W, Bondy B, Jernej B (2004) 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations. Eur Arch Psychiatry Clin Neurosci 254:224–227PubMed

32.

WHO (2005) Burden of mental and behavioural disorders: suicide

33.

Xie E, Zhu L, Zhao L, Chang LS (1996) The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant. Genomics 35:551–561PubMedCrossRef

34.

Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka K (2000) Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia 43:373–376PubMedCrossRef

Titel: 5-ht2c receptor and mao-a interaction analysis: no association with suicidal behaviour in bipolar patients
verfasst von: Vincenzo De Luca
Subi Tharmaligam
John Strauss
James L. Kennedy
Publikationsdatum: 01.10.2008
Verlag: D. Steinkopff-Verlag
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 7/2008
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-008-0815-x

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 7/2008

Comorbidity of adult attention-deficit hyperactivity disorder and bipolar disorder: prevalence and clinical correlates

Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate

Insight, cognitive dysfunction and symptomatology in schizophrenia

The beginnings of modern psychiatric treatment in Europe