The authors declare that they have no competing interests.
JB was involved in postoperative care of the patient after pancreatic resection, wrote the case report, made literature review and drafted the manuscript. US and CB were the main persons involved in preoperative detection of pancreatic mass and revised the manuscript. MF and AP were involved in diagnosis, adjuvant treatment and follow-up before and after resection of primary tumor and metastasis to the pancreas. Both revised the paper. VW performed conventional and immunohistochemical staining of pancreatic ACC metastasis and revised the manuscript. US performed pancreatic resection, was involved in postoperative care of the patient and revised the manuscript. All authors read and approved the final manuscript.
Solitary metastases to the pancreas are rare. Therefore the value of resection in curative intention remains unclear. In the literature there are several promising reports about resection of solitary metastasis to the pancreas mainly of renal origin.
Here we report for the first time on the surgical therapy of a 1.5 cm solitary pancreatic metastasis of an adrenocortical carcinoma. The metastasis occurred almost 6 years after resection of the primary tumor. A partial pancreatoduodenectomy was performed and postoperatively adjuvant mitotane treatment was initiated. During the follow-up of 3 years after surgery no evidence of tumor recurrence occurred.
Resection of pancreatic tumors should be considered, even if the mass is suspicious for metastatic disease including recurrence of adrenocortical cancer.
Fassnacht M, Johanssen S, Quinkler M, Bucsky P, Willenberg HS, Beuschlein F, et al. Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma: proposal for a Revised TNM Classification. Cancer. 2009;115:5847. CrossRef
Berruti A, Baudin E, Gelderblom H, Haak HR, Porpiglia F, Fassnacht M, et al. Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23 Suppl 7.
- A case report of a solitary pancreatic metastasis of an adrenocortical carcinoma
- BioMed Central
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