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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

A complete response to S-1 plus cis-diamminedichloroplatinum in advanced-stage esophageal and gastric adenocarcinoma: a case report

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Yoritaka Matsuno, Mitsugu Kochi, Masashi Fujii, Noriaki Kanamori, Teruo Kaiga, Yoshiaki Mihara, Tomoya Funada, Teruyuki Miyazaki, Tadatoshi Takayama
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-133) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YM reviewed relevant literature and wrote the initial draft. MK wrote and reviewed the initial draft. MF provided clinical expertise and reviewed the manuscript. NK contributed the CT scans images. TK performed the chemotherapy and reviewed the manuscript. YM performed the chemotherapy and reviewed the manuscript. TF performed the chemotherapy and reviewed the manuscript. TM performed the chemotherapy and reviewed the manuscript. TT provided clinical expertise and reviewed the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Complete remission from advanced-stage synchronous double primary (SDP) esophageal and gastric adenocarcinoma by chemotherapy alone is rare. We report a case of advanced-stage SDP esophageal and gastric adenocarcinoma in which a complete response to treatment was obtained with S-1 and cis-diamminedichloroplatinum (CDDP).

Case presentation

The patient was a 74-year-old man referred to our hospital complaining of dysphagia. Gastrointestinal endoscopy was performed and advanced-stage SDP esophageal and gastric adenocarcinoma diagnosed. Computed tomography revealed multiple regional lymph node metastases in the mediastinum. Neoadjuvant chemotherapy with S-1 and CDDP for advanced esophageal and gastric cancer was planned. An endoscopy following two courses of chemotherapy revealed that the esophageal cancer had been replaced with a normal mucosal lesion and the gastric tumor with a scar lesion; the results of biopsies of both were negative for cancer. Computed tomography revealed that the multiple lymph node metastases had disappeared. We diagnosed a complete response to S-1 and CDDP in advanced-stage SDP esophageal and gastric cancer. The patient is still alive with no signs of recurrence 22 months after the disappearance of the original tumor and metastatic lesions without surgical treatment.

Conclusion

These results suggest that complete remission from advanced-stage esophageal and gastric cancer can be obtained with chemotherapy with S-1 plus CDDP.
Zusatzmaterial
Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Authors’ original file for figure 4
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Authors’ original file for figure 5
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Authors’ original file for figure 6
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Literatur
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