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18.04.2019 | Review Article

A complex relation between depression and multiple sclerosis: a descriptive review

verfasst von: Francesco Corallo, Viviana Lo Buono, Roberto Genovese, Rosanna Palmeri, Marcella Di Cara, Carmela Rifici, Edoardo Sessa, Giangaetano D’Aleo, Francesco Galletti, Lilla Bonanno, Silvia Marino

Erschienen in: Neurological Sciences | Ausgabe 8/2019

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Abstract

Background

Multiple sclerosis (MS) is a demyelinating neurodegenerative disease that affects central nervous system (CNS). MS patients are more likely to develop depressive symptoms than patients with other chronic diseases.

Objective

In this review, we have analysed if there is a correlation between brain lesions (BL), structural damage (SD) and depressive symptoms (DS).

Methods

We Searched on PubMed and Web of Science databases and screening references of included studied and some review article for additional citations. From initial 745 studies, only 9 met the inclusion criteria. All studies conducted research on 389 patients with MS associated with DS and 120 HC (healthy controls).

Results

The selected researches highlighted the involvement of limbic system, the role of hippocampus and the impact of brain lesions on the emotional status of MS patients.

Discussion

In the genesis of depression are implicated many mechanisms including genetic, biochemical, immunological and psychosocial factors, even if a prominent role in the onset of DS seem to be associated with structural and functional brain alterations.

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Titel: A complex relation between depression and multiple sclerosis: a descriptive review
verfasst von: Francesco Corallo
Viviana Lo Buono
Roberto Genovese
Rosanna Palmeri
Marcella Di Cara
Carmela Rifici
Edoardo Sessa
Giangaetano D’Aleo
Francesco Galletti
Lilla Bonanno
Silvia Marino
Publikationsdatum: 18.04.2019
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 8/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03889-1

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Springer Medizin

A complex relation between depression and multiple sclerosis: a descriptive review

Abstract

Background

Objective

Methods

Results

Discussion

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Springer Medizin

Abstract

Background

Objective

Methods

Results

Discussion

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