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Clinical Reviews in Allergy & Immunology

Erschienen in:

01.04.2011

A Contemporary Update on Scleroderma

verfasst von: Loïc Guillevin

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2011

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Excerpt

Systemic sclerosis is a rare disease which remains, by many aspects, an enigma and a therapeutic challenge for physicians. It is one of the last “autoimmune” diseases to have a poor prognosis and respond poorly to treatments. The treatment of scleroderma has been very problematic for a number of reasons. Firstly, the genetic basis, although intensely studied, remains unclear and there are no definitive genome-wide association studies published. Second, the pathogenesis of systemic sclerosis is complex, associating several mechanisms including endothelial dysfunction, fibrosis, autoimmunity, and allo-reactivity. Further, all these mechanisms may be inter-related and may change during the disease course. Hence, therapy is a challenge. Further, should therapy focus entirely on specific organ involvement or will there be specific drugs that will modulate the course of disease? Will there ever be drugs that target the complexity of mechanisms present at each disease stage? …

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Titel: A Contemporary Update on Scleroderma
verfasst von: Loïc Guillevin
Publikationsdatum: 01.04.2011
Verlag: Humana Press Inc
Erschienen in: Clinical Reviews in Allergy & Immunology / Ausgabe 2/2011
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI: https://doi.org/10.1007/s12016-010-8200-8

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A Contemporary Update on Scleroderma

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