A decade of Alzheimer’s Research & Therapy: reflections on the past, present, and future

Our impact factor has steadily increased to 6.142, as of the 2018 Journal Citation Report, as shown in the figure. We hope to see this trend continue with the release of the 2019 report in June. The journal has been consistently ranked in the first quartile for Clinical Neurology as well as Neuroscience journals. As can be seen in an excerpt from the most recent Publisher’s Report in Table 1, we have published papers from authors from across the globe. North America, Europe/UK, Australia, China, Taiwan, and South Korea predominate, but Africa, India, South America, and Middle Eastern submissions and publications are represented. Because one of our areas of focus is on new therapeutic development for Alzheimer’s, we have had, and welcome, submissions from Industry. Although some publications are outliers, we have maintained an average time from submission to first decision of 60 days and are constantly reaching out to broaden our pool of reviewers.

(2018 Journal Citation Reports® (Clarivate Analytics, 2018))

The table lists the top 10 accessed articles in the past year. This reflects precisely the scope of our journal: covering the breadth of the field from a translational point of view with a clear focus on therapy. Also, the highly accessed reviews on dementia with Lewy bodies and chronic traumatic encephalopathy demonstrate how research on other disorders that may cause dementia complements the landscape of Alzheimer’s research.

Following this brief summary of our 10 years of existence, it is time to reflect: what is good, what can be done better, and what should we reconsider? And how should the past decade of research into Alzheimer’s influence these ideas? This decade has been marked by the frustration of therapeutic failures in Alzheimer’s that have led some to question the amyloid hypothesis as a central dogma, the emergence of tau-related therapeutic efforts, exciting developments in biomarkers—including brain imaging and CSF- and blood-based markers—and increasing awareness of the importance of neuroinflammation. A biomarker-based classification of Alzheimer’s that enables detection and can support intervention studies before the development of cognitive decline is receiving extensive investigation. Digital biomarkers including passive sensors, wearables, and device-based testing are increasingly being studied and deployed. Neuropathological and biomarker studies are demonstrating the concept that multiple pathologies contribute to neurodegeneration and cognitive decline. Extrinsic factors that may contribute to brain development, resilience, reserve, and vulnerability are being widely studied and have been conceptualized as the exposome. Efforts to understand Alzheimer’s and related disorders from a genetic, molecular, and -omic standpoint are burgeoning. These have led to renewed attention to preclinical models of disease, from cell-based models (including human models derived from iPS-cell technology) to animal models. New methods of protein analysis, including cryo-electron microscopy, are providing insights into the structure of proteins, including aggregated proteins emblematic of Alzheimer’s and related disorders. Drug discovery and translation now include small molecules, immunological therapies, and biological approaches, as well as efforts to investigate the impacts and biology of lifestyle interventions.

Against this background, we believe that the overall scope of the journal should be retained: translational research into Alzheimer’s, with the additional emphasis that we should also include and learn from other types of dementia, neurodegenerative, or otherwise. Translational research encompasses clinical perspectives, biomarkers, genetics, epidemiology, pathology, mechanisms of disease relevant to translation, and therapy across all stages of development, and in particular research with interactions or translation between these areas! We are interested in cognition and cognitive reserve and on early changes along the Alzheimer continuum, as evidenced by a recent thematic series. We are less interested in observational research (for example, epidemiology in healthy aging subjects), basic research on aging, animal models outside of translational studies, or cognitive/behavioral studies in healthy (elderly) individuals. We are interested in meta-analyses and studies of large healthcare databases only if they have substantial novelty and impact.

Original data papers, reviews, and thematic series remain the mainstay of our publications. Topics for thematic series have been and will be developed with extensive input from the Editorial Board. Some recent examples are shown in the table (see Table 2). We have published relatively few debates, opinions, or commentaries and do not intend to change that policy, although we may make an occasional exception, when a paper evokes a serious debate or has novel/controversial findings.

Next to us as Editors-in-Chief, we have invited Associate Editors (see Table 3), including one Biostatistical Advisory Editor, to help us assess the growing number of original manuscripts that we receive. The Associate Editors will help us to cover the broad range of expertise needed to handle diverse research topics. They will help in assessing papers, searching for reviewers, and handling papers up until the final decision which is made by the Editors-in-Chief. By asking them to help us, we aim to be able to handle more submissions with greater timeliness. This expanded Editorial Team will exercise the option to reject a paper outright if it is judged outside of the scope of the journal, is of too low quality to send out for review, and overlaps with or repeats another published paper. Except for the statement that the manuscript falls below the standards of Alz R&T, the editors will not provide a specific reason for this immediate rejection. By doing this, we hope this will help authors to seek a more appropriate home for their submission without unnecessary delays. We may add further Associate Editors in the future.

We remain committed to as rapid a turnaround time as possible from submission, through reviews and to first Editorial decision. To accomplish this, we need many reviewers with diverse knowledge and skills, and we deeply appreciate the helpful responses we have had from many colleagues to serve in this capacity over the years. As with everyone in the field, we are all very busy, but if authors want their papers to be reviewed by capable reviewers, we ask our authors in return also to agree to review. We are all in this together!

We are delighted to announce that we will soon partner with Alzheimer’s Research UK! The Editors are highly enthusiastic about this because it will open up a new audience for our journal, may attract new authors and reviewers, will allow us to explore scientific publications on events organized by ARUK, and will provide a solid backbone by an organization dedicated to Alzheimer’s disease research.

We thank our authors and reviewers for their continuing support for our journal to the benefit of the next decade of better and more groundbreaking research to finally defeat the disease which at the core of our minds.