Introduction
Methods
Data sources for MR analyses and selection of the genetic instruments
Testing MR assumptions and statistical analysis
Results
MR assessing 25(OH)D effects on ADHD
SNP | 25(OH)D | ADHD | Palindromic + ambiguous | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A1 | A2 | Eaf (A1) | Beta | SE | P value | A1 | A2 | OR | SE | P value | |||
rs10741657 | CYP2R1 | A | G | 0.40 | 0.031 | 0.0022 | 2.05E–46 | A | G | 1.0048 | 0.0137 | 0.728 | False |
rs10745742 | AMDHD1 | T | C | 0.40 | 0.017 | 0.0022 | 1.88E–14 | T | C | 1.0141 | 0.0138 | 0.311 | False |
rs12785878 | NADSYN1-DHCR7 | T | G | 0.75 | 0.036 | 0.0022 | 3.80E–62 | T | G | 1.0313 | 0.0146 | 0.035 | False |
rs17216707a | CYP24A1 | T | C | 0.77 | 0.026 | 0.0027 | 8.14E–23 | ||||||
ars209955 | T | C | 0.31b | − 0.019 | 0.0024 | 2.49E−16 | T | C | 1.003 | 0.0156 | 0.848 | False | |
rs3755967 | GC | T | C | 0.28 | − 0.089 | 0.0023 | 4.74E–343 | T | C | 1.0235 | 0.015 | 0.122 | False |
rs8018720 | SEC23A | C | G | 0.82 | − 0.017 | 0.0029 | 4.72E–09 | C | G | 0.9958 | 0.0185 | 0.819 | True |
SNP | Beta | SE | P value |
---|---|---|---|
rs10741657 | 0.155 | 0.438 | 0.724 |
rs10745742 | 0.824 | 0.789 | 0.297 |
rs12785878 | 0.856 | 0.382 | 0.024 |
rs209955 | − 0.155 | 0.803 | 0.847 |
rs3755967 | − 0.261 | 0.161 | 0.105 |
Inverse variance weighted | − 0.043 | 0.202 | 0.833 |
MR Egger | − 0.457 | 0.301 | 0.227 |
Weighted median | − 0.221 | 0.158 | 0.162 |
Simple mode | − 0.074 | 0.466 | 0.881 |
Weighted mode | − 0.230 | 0.161 | 0.226 |
MR assessing ADHD effects on 25(OH)D
SNP | Chr | Position | ADHD | 25(OH)D | Palindromic + ambigous | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A1 | A2 | A1 freq | OR | SE | P value | A1 | A2 | Beta | SE | P value | ||||
rs11420276a | 1 | 44184192 | G | GT | 0.696 | 1.11305 | 0.0149 | 6.452e−13 | ||||||
rs11591402 | 10 | 106747354 | A | T | 0.224 | 0.91174 | 0.0164 | 1.76e−08 | A | T | 0.0012 | 0.0025 | 0.6195 | True |
rs1222063b | 1 | 96602440 | A | G | 0.328 | 1.10098 | 0.0174 | 3.068e−08 | ||||||
brs1222067 | 1 | 96597502 | A | C | 0.688 | 0.92635 | 0.0155 | 7.908e−07 | A | C | 0.0008 | 0.0026 | 0.7464 | False |
rs1427829 | 12 | 89760744 | A | G | 0.434 | 1.08567 | 0.0136 | 1.349e−09 | A | G | 0.0027 | 0.0021 | 0.1974 | False |
rs212178c | 16 | 72578131 | A | G | 0.883 | 0.88950 | 0.0205 | 1.198e−08 | ||||||
crs12596294 | 16 | 72587093 | A | T | 0.098 | 1.12008 | 0.0207 | 4.157e−08 | A | T | 0.0029 | 0.0034 | 0.3873 | True |
rs281324 | 15 | 47754018 | T | C | 0.531 | 0.92450 | 0.0135 | 6.684e−09 | T | C | 0.0024 | 0.0021 | 0.2426 | False |
rs28411770d | 4 | 31151456 | T | C | 0.651 | 1.08992 | 0.0151 | 1.152e−08 | ||||||
drs7674790 | 4 | 31149277 | A | T | 0.610 | 1.07455 | 0.014 | 2.996e−07 | A | T | 0.0002 | 0.0022 | 0.9348 | True |
rs4858241e | 3 | 20669071 | T | G | 0.622 | 1.08567 | 0.0143 | 8.172e−09 | ||||||
ers17808771 | 3 | 20691823 | A | T | 0.758 | 1.07326 | 0.0153 | 3.773e−06 | A | T | 0.0008 | 0.0024 | 0.7341 | True |
rs4916723 | 5 | 87854395 | A | C | 0.573 | 0.92515 | 0.0138 | 1.807e−08 | A | C | − 0.0016 | 0.0021 | 0.4515 | False |
rs5886709f | 7 | 114086133 | G | GTC | 0.463 | 1.07993 | 0.0137 | 2.056e−08 | ||||||
rs74760947g | 8 | 34352610 | A | G | 0.957 | 0.83560 | 0.0317 | 1.393e−08 | ||||||
grs6990255 | 8 | 34126948 | T | C | 0.0586481 | 1.18270 | 0.0315 | 1.03e−07 | T | C | − 0.0058 | 0.0043 | 0.1779 | False |
rs9677504 | 2 | 215181889 | A | G | 0.109 | 1.12019 | 0.0213 | 9.829e−08 | A | G | 0.0012 | 0.0033 | 0.7171 | False |
SNP | Beta | SE | P value |
---|---|---|---|
rs1222067 | − 0.010 | 0.034 | 0.758 |
rs1427829 | 0.033 | 0.026 | 0.199 |
rs281324 | − 0.031 | 0.027 | 0.253 |
rs4916723 | 0.0206 | 0.027 | 0.446 |
rs6990255 | − 0.035 | 0.026 | 0.177 |
rs9677504 | 0.011 | 0.029 | 0.716 |
Inverse variance weighted | − 0.002 | 0.012 | 0.887 |
MR Egger | − 0.048 | 0.049 | 0.377 |
Weighted median | 0.002 | 0.015 | 0.900 |
Simple mode | 0.015 | 0.026 | 0.571 |
Weighted mode | 0.019 | 0.027 | 0.514 |