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07.11.2020 | Original Contribution

Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study

verfasst von: Vinicius A. do Rosario, Danielle A. J. M. Schoenaker, Katherine Kent, Katrina Weston-Green, Karen Charlton

Erschienen in: European Journal of Nutrition | Ausgabe 5/2021

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Abstract

Purpose

Epidemiological evidence suggests higher dietary flavonoid intake is associated with lower risk of several chronic diseases. This study aimed to investigate the association between intake of flavonoids and their subclasses, and incidence of hypertension among Australian women in two age cohorts.

Methods

This population-based study included 6599 middle-aged (52.5 ± 1.5 years) and 6099 reproductive-aged (27.5 ± 1.5 years) women from the Australian Longitudinal Study on Women’s Health. Food frequency questionnaires were used to quantify intake of flavonoids by cross‐referencing with the Phenol-Explorer food composition database. Generalised Estimating Equation analyses investigated associations with incident hypertension, adjusting for demographic and dietary variables and hypertension risk factors.

Results

There were 1645 cases (24.9%) of hypertension during 15 years follow-up in the middle-aged cohort and 336 cases (5.5%) during 12 years follow-up in the reproductive-aged cohort. Higher intakes of flavones [adjusted relative risk (ARR) for quintile 5 vs. 1: 0.82, 95% CI 0.70–0.97], isoflavones (0.86, 0.75–0.99) and flavanones (0.83, 0.69–1.00) were associated with a lower risk of hypertension in the middle-aged cohort. In the reproductive-aged cohort, higher intakes of flavanols (0.70, 0.49–0.99) were associated with a lower risk of hypertension. Key foods that provided these flavonoids were oranges, orange juice, apples, red wine and soy milk.

Conclusion

Higher intakes of total flavonoids and subclasses were associated with a lower risk of hypertension in Australian women. These findings can be used in nutrition messaging and policies for improved cardiovascular health of women.

Nur mit Berechtigung zugänglich

Foundation TH Australian heart disease statistics. In: The Heart Foundation. https://www.heartfoundation.org.au/about-us/what-we-do/heart-disease-in-australia/australian-heart-disease-statistics. Accessed 10 Oct 2019

Iqbal AM, Jamal SF (2019) Essential hypertension. In: StatPearls. StatPearls Publishing, Treasure Island (FL)

Crowley SD (2014) The cooperative roles of inflammation and oxidative stress in the pathogenesis of hypertension. Antioxid Redox Signal 20:102–120. https://doi.org/10.1089/ars.2013.5258CrossRefPubMedPubMedCentral

Higashi Y, Noma K, Yoshizumi M, Kihara Y (2009) Endothelial function and oxidative stress in cardiovascular diseases. Circ J 73:411–418. https://doi.org/10.1253/circj.cj-08-1102CrossRefPubMed

Stocker R, Keaney JF (2004) Role of oxidative modifications in atherosclerosis. Physiol Rev 84:1381–1478. https://doi.org/10.1152/physrev.00047.2003CrossRefPubMed

Muñoz A, Costa M (2013) Nutritionally mediated oxidative stress and inflammation. Oxid Med Cell Long 2013:1–11. https://doi.org/10.1155/2013/610950CrossRef

Ndanuko RN, Tapsell LC, Charlton KE et al (2016) Dietary patterns and blood pressure in adults: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr 7:76–89. https://doi.org/10.3945/an.115.009753CrossRefPubMedPubMedCentral

Pandey KB, Rizvi SI (2009) Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2:270–278CrossRef

Kumar S, Pandey AK (2013) Chemistry and biological activities of flavonoids: an overview. Sci World J. https://www.hindawi.com/journals/tswj/2013/162750/. Accessed 21 Mar 2018

10.

Williams RJ, Spencer JPE, Rice-Evans C (2004) Flavonoids: antioxidants or signalling molecules? Free Radical Biol Med 36:838–849. https://doi.org/10.1016/j.freeradbiomed.2004.01.001CrossRef

11.

Godos J, Vitale M, Micek A et al (2019) Dietary polyphenol intake, blood pressure, and hypertension: a systematic review and meta-analysis of observational studies. Antioxidants (Basel). https://doi.org/10.3390/antiox8060152CrossRef

12.

Ried K, Fakler P, Stocks NP (2017) Effect of cocoa on blood pressure. Cochrane Database Syst Rev 4:CD008893. https://doi.org/10.1002/14651858.CD008893.pub3CrossRefPubMed

13.

Serban M, Sahebkar A, Zanchetti A et al (2016) Effects of quercetin on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Am Heart Assoc. https://doi.org/10.1161/JAHA.115.002713CrossRefPubMedPubMedCentral

14.

Mishra GD, McNaughton SA, Ball K et al (2010) Major dietary patterns of young and middle aged women: results from a prospective Australian cohort study. Eur J Clin Nutr 64:1125–1133. https://doi.org/10.1038/ejcn.2010.121CrossRefPubMed

15.

Dobson AJ, Hockey R, Brown WJ et al (2015) Cohort profile update: Australian Longitudinal Study on Women’s Health. Int J Epidemiol 44:1547–1547f. https://doi.org/10.1093/ije/dyv110CrossRefPubMed

16.

Lee C, Dobson AJ, Brown WJ et al (2005) Cohort profile: the Australian Longitudinal Study on Women’s Health. Int J Epidemiol 34:987–991. https://doi.org/10.1093/ije/dyi098CrossRefPubMed

17.

Ireland P, Jolley D, Giles G et al (1994) Development of the Melbourne FFQ: a food frequency questionnaire for use in an Australian prospective study involving an ethnically diverse cohort. Asia Pac J Clin Nutr 3:19–31PubMed

18.

Hodge A, Patterson AJ, Brown WJ et al (2000) The anti cancer council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation. Aust N Z J Public Health 24:576–583. https://doi.org/10.1111/j.1467-842x.2000.tb00520.xCrossRefPubMed

19.

Lewis J, Milligan GC, Hunt A, National Food Authority (Australia) (1995) NUTTAB 95: nutrient data table for use in Australia

20.

Rothwell JA, Perez-Jimenez J, Neveu V et al (2013) Phenol-explorer 3.0: a major update of the phenol-explorer database to incorporate data on the effects of food processing on polyphenol content. Database (Oxford) 2013:70. https://doi.org/10.1093/database/bat070CrossRef

21.

Elstgeest LEM, Mishra GD, Dobson AJ (2012) Transitions in living arrangements are associated with changes in dietary patterns in young women. J Nutr 142:1561–1567. https://doi.org/10.3945/jn.112.158188CrossRefPubMed

22.

Baldwin JN, Forder PM, Haslam RL et al (2020) Change in diet quality over 12 years in the 1946–1951 cohort of the Australian Longitudinal Study on Women’s Health. Nutrients. https://doi.org/10.3390/nu12010147CrossRefPubMedPubMedCentral

23.

Vissers LET, Waller M, van der Schouw YT et al (2017) A pro-inflammatory diet is associated with increased risk of developing hypertension among middle-aged women. Nutr Metab Cardiovasc Dis 27:564–570. https://doi.org/10.1016/j.numecd.2017.03.005CrossRefPubMed

24.

Brown WJ, Bauman AE, Bull F, Burton NW (2013) Development of evidence-based physical activity recommendations for adults (18–64 years). Report prepared for the Australian Government Department of Health, August 2012.

25.

Amier A, Suzanne O (2017) Hypertension in Women. Hypertension 70:19–26. https://doi.org/10.1161/HYPERTENSIONAHA.117.08317CrossRef

26.

Cassidy A, O’Reilly ÉJ, Kay C et al (2011) Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr 93:338–347. https://doi.org/10.3945/ajcn.110.006783CrossRefPubMed

27.

Lajous M, Rossignol E, Fagherazzi G et al (2016) Flavonoid intake and incident hypertension in women. Am J Clin Nutr 103:1091–1098. https://doi.org/10.3945/ajcn.115.109249CrossRefPubMed

28.

Chun OK, Chung SJ, Song WO (2007) Estimated dietary flavonoid intake and major food sources of U.S. adults. J Nutr 137:1244–1252. https://doi.org/10.1093/jn/137.5.1244CrossRefPubMed

29.

Ivey KL, Croft K, Prince RL, Hodgson JM (2016) Comparison of flavonoid intake assessment methods. Food Funct 7:3748–3759. https://doi.org/10.1039/c4fo00234bCrossRefPubMed

30.

Singh M, Kaur M, Silakari O (2014) Flavones: an important scaffold for medicinal chemistry. Eur J Med Chem 84:206–239. https://doi.org/10.1016/j.ejmech.2014.07.013CrossRefPubMed

31.

Clark JL, Zahradka P, Taylor CG (2015) Efficacy of flavonoids in the management of high blood pressure. Nutr Rev 73:799–822. https://doi.org/10.1093/nutrit/nuv048CrossRefPubMed

32.

Hügel HM, Jackson N, May B et al (2016) Polyphenol protection and treatment of hypertension. Phytomedicine 23:220–231. https://doi.org/10.1016/j.phymed.2015.12.012CrossRefPubMed

33.

Ahuja V, Miura K, Vishnu A et al (2017) Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men. Br J Nutr 117:260–266. https://doi.org/10.1017/S000711451600458XCrossRefPubMedPubMedCentral

34.

Maaliki D, Shaito AA, Pintus G et al (2019) Flavonoids in hypertension: a brief review of the underlying mechanisms. Curr Opin Pharmacol 45:57–65. https://doi.org/10.1016/j.coph.2019.04.014CrossRefPubMed

35.

Probst Y, Guan V, Kent K (2018) A systematic review of food composition tools used for determining dietary polyphenol intake in estimated intake studies. Food Chem 238:146–152. https://doi.org/10.1016/j.foodchem.2016.11.010CrossRefPubMed

36.

Igwe EO, Charlton KE, Probst YC (2019) Usual dietary anthocyanin intake, sources and their association with blood pressure in a representative sample of Australian adults. J Hum Nutr Diet 32:578–590. https://doi.org/10.1111/jhn.12647CrossRefPubMed

37.

Benjamin M, Hernandez AV, Alberts MJ et al (2020) Incidence and predictors of major adverse cardiovascular events in patients with established atherosclerotic disease or multiple risk factors. J Am Heart Assoc 9:e014402. https://doi.org/10.1161/JAHA.119.014402CrossRef

Titel: Association between flavonoid intake and risk of hypertension in two cohorts of Australian women: a longitudinal study
verfasst von: Vinicius A. do Rosario
Danielle A. J. M. Schoenaker
Katherine Kent
Katrina Weston-Green
Karen Charlton
Publikationsdatum: 07.11.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02424-9

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