Skip to main content
Erschienen in: Sleep and Breathing 2/2022

09.06.2021 | Sleep Breathing Physiology and Disorders • Original Article

A meta-analysis of the diagnostic value of NoSAS in patients with sleep apnea syndrome

verfasst von: Huimin Chen, Zhenzhen Zheng, Riken Chen, Yu Zeng, Nanhong Li, Jinru Zhu, Yue Zhong, Haimin Liu, Jianmin Lu, Nuofu Zhang, Cheng Hong

Erschienen in: Sleep and Breathing | Ausgabe 2/2022

Einloggen, um Zugang zu erhalten

Abstract

Objective

The NoSAS score is a new tool widely used in recent years to screen for obstructive sleep apnea. A number of studies have shown that the NoSAS score is more accurate than previous tools, such as the Berlin, STOP-Bang, and STOP questionnaires. Therefore, this meta-analysis assessed the diagnostic value of the NoSAS score for sleep apnea syndrome in comparison to polysomnography.

Methods

Two researchers searched the PubMed, EMBASE, Cochrane, and Web of Science databases through November 13, 2020. This paper used Endnote9.3 software to manage the literature and RevMan 5.3 and STATA12.0 software to perform the meta-analysis.

Results

A total of 10 studies were included in this meta-analysis, including 14,510 patients. The meta-analysis showed that the pooled sensitivity was 0.798 (95% CI 0.757, 0.833), the pooled specificity was 0.582 (95% CI 0.510, 0.651), the positive likelihood ratio was 1.909 (95% CI 1.652, 2.206), the negative likelihood ratio was 0.347 (95% CI 0.300, 0.403), the diagnostic OR was 5.495 (95% CI 4.348, 6.945), and the area under the SROC curve was 0.77 (95% CI 0.73, 0.80). The NoSAS score has good efficacy in identifying patients likely to have obstructive sleep apnea.

Conclusion

The NoSAS score can accurately identify patients likely to have obstructive sleep apnea. Therefore, in the absence of polysomnography, one should use the NoSAS score to evaluate patients with suspected sleep apnea syndrome.
Literatur
1.
Zurück zum Zitat Arnardottir ES, Bjornsdottir E, Olafsdottir KA, Benediktsdottir B, Gislason T (2016) Obstructive sleep apnoea in the general population: highly prevalent but minimal symptoms. Eur Respir J 47(1):194–202CrossRef Arnardottir ES, Bjornsdottir E, Olafsdottir KA, Benediktsdottir B, Gislason T (2016) Obstructive sleep apnoea in the general population: highly prevalent but minimal symptoms. Eur Respir J 47(1):194–202CrossRef
2.
Zurück zum Zitat Kendzerska T, Gershon AS, Hawker G, Tomlinson G, Leung RS (2014) Obstructive sleep apnea and incident diabetes. A historical cohort study. Am J Respir Crit Care Med. 190(2):218–225CrossRef Kendzerska T, Gershon AS, Hawker G, Tomlinson G, Leung RS (2014) Obstructive sleep apnea and incident diabetes. A historical cohort study. Am J Respir Crit Care Med. 190(2):218–225CrossRef
3.
Zurück zum Zitat Finkel KJ, Searleman AC, Tymkew H et al (2009) Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center. Sleep Med 10(7):753–758CrossRef Finkel KJ, Searleman AC, Tymkew H et al (2009) Prevalence of undiagnosed obstructive sleep apnea among adult surgical patients in an academic medical center. Sleep Med 10(7):753–758CrossRef
4.
Zurück zum Zitat Devaraj U, Rajagopala S, Kumar A, Ramachandran P, Devereaux PJ, D’Souza GA (2017) Undiagnosed obstructive sleep apnea and postoperative outcomes: a prospective observational study. Respiration 94(1):18–25CrossRef Devaraj U, Rajagopala S, Kumar A, Ramachandran P, Devereaux PJ, D’Souza GA (2017) Undiagnosed obstructive sleep apnea and postoperative outcomes: a prospective observational study. Respiration 94(1):18–25CrossRef
5.
Zurück zum Zitat Shah N, Roux F (2009) The relationship of obesity and obstructive sleep apnea. Clin Chest Med 30(3):455–465CrossRef Shah N, Roux F (2009) The relationship of obesity and obstructive sleep apnea. Clin Chest Med 30(3):455–465CrossRef
6.
Zurück zum Zitat Marshall N, Delling L, Grunstein R et al (2011) Self-reported sleep apnoea and mortality in patients from the Swedish Obese Subjects study. Eur Respir J 38(6):1349–1354CrossRef Marshall N, Delling L, Grunstein R et al (2011) Self-reported sleep apnoea and mortality in patients from the Swedish Obese Subjects study. Eur Respir J 38(6):1349–1354CrossRef
7.
Zurück zum Zitat Tufik S, Andersen ML, Bittencourt LR, Mello MTd (2009) Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research. Anais da Academia Brasileira de Ciências. 81(3):521–538CrossRef Tufik S, Andersen ML, Bittencourt LR, Mello MTd (2009) Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research. Anais da Academia Brasileira de Ciências. 81(3):521–538CrossRef
8.
Zurück zum Zitat Knauert M, Naik S, Gillespie MB, Kryger M (2015) Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World J Otorhinolaryngol-Head Neck Surg 1(1):17–27CrossRef Knauert M, Naik S, Gillespie MB, Kryger M (2015) Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome. World J Otorhinolaryngol-Head Neck Surg 1(1):17–27CrossRef
9.
Zurück zum Zitat Senaratna CV, Perret JL, Lodge CJ et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81CrossRef Senaratna CV, Perret JL, Lodge CJ et al (2017) Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev 34:70–81CrossRef
10.
Zurück zum Zitat Marti-Soler H, Hirotsu C, Marques-Vidal P et al (2016) The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study. Lancet Respir Med 4(9):742–748CrossRef Marti-Soler H, Hirotsu C, Marques-Vidal P et al (2016) The NoSAS score for screening of sleep-disordered breathing: a derivation and validation study. Lancet Respir Med 4(9):742–748CrossRef
11.
Zurück zum Zitat Tan A, Hong Y, Tan LW, van Dam RM, Cheung YY, Lee C-H (2017) Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population. Sleep Breath 21(4):1033–1038CrossRef Tan A, Hong Y, Tan LW, van Dam RM, Cheung YY, Lee C-H (2017) Validation of NoSAS score for screening of sleep-disordered breathing in a multiethnic Asian population. Sleep Breath 21(4):1033–1038CrossRef
12.
Zurück zum Zitat Hong C, Chen R, Qing S et al (2018) Validation of the NoSAS score for the screening of sleep-disordered breathing: a hospital-based retrospective study in China. J Clin Sleep Med 14(2):191–197CrossRef Hong C, Chen R, Qing S et al (2018) Validation of the NoSAS score for the screening of sleep-disordered breathing: a hospital-based retrospective study in China. J Clin Sleep Med 14(2):191–197CrossRef
13.
Zurück zum Zitat Duarte RL, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Silva JA, Mello FC, Gozal D (2020) Obstructive sleep apnea screening with a 4-item instrument, named GOAL Questionnaire: development, validation and comparative study with No-Apnea, STOP-Bang, and NoSAS. Nat Sci Sleep 12:57CrossRef Duarte RL, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Silva JA, Mello FC, Gozal D (2020) Obstructive sleep apnea screening with a 4-item instrument, named GOAL Questionnaire: development, validation and comparative study with No-Apnea, STOP-Bang, and NoSAS. Nat Sci Sleep 12:57CrossRef
14.
Zurück zum Zitat Veugen CC, Teunissen EM, den Otter LA, Kos MP, Stokroos RJ, Copper MP (2020) Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index. Sleep Breath 1–9 Veugen CC, Teunissen EM, den Otter LA, Kos MP, Stokroos RJ, Copper MP (2020) Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index. Sleep Breath 1–9
15.
Zurück zum Zitat Duarte RL, Mello FC, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Rabahi MF, Gozal D (2019) Comparative performance of screening instruments for obstructive sleep apnea in morbidly obese patients referred to a sleep laboratory: a prospective cross-sectional study. Sleep Breath 23(4):1123–1132CrossRef Duarte RL, Mello FC, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Rabahi MF, Gozal D (2019) Comparative performance of screening instruments for obstructive sleep apnea in morbidly obese patients referred to a sleep laboratory: a prospective cross-sectional study. Sleep Breath 23(4):1123–1132CrossRef
16.
Zurück zum Zitat Chen R, Liu W, Cheng J et al (2019) The No-apnea score vs. the other five questionnaires in screening for obstructive sleep apnea-hypopnea syndrome in patients with cerebral infarction. J Thorac Dis. 11(10):4179CrossRef Chen R, Liu W, Cheng J et al (2019) The No-apnea score vs. the other five questionnaires in screening for obstructive sleep apnea-hypopnea syndrome in patients with cerebral infarction. J Thorac Dis. 11(10):4179CrossRef
17.
Zurück zum Zitat Duarte RL, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Rabahi MF, Mello FC, Gozal D (2019) Predicting obstructive sleep apnea in patients with insomnia: a comparative study with four screening instruments. Lung 197(4):451–458CrossRef Duarte RL, Magalhães-da-Silveira FJ, Oliveira-e-Sá TS, Rabahi MF, Mello FC, Gozal D (2019) Predicting obstructive sleep apnea in patients with insomnia: a comparative study with four screening instruments. Lung 197(4):451–458CrossRef
18.
Zurück zum Zitat Peng M, Chen R, Cheng J, Li J, Liu W, Hong C (2018) Application value of the NoSAS score for screening sleep-disordered breathing. J Thorac Dis 10(8):4774CrossRef Peng M, Chen R, Cheng J, Li J, Liu W, Hong C (2018) Application value of the NoSAS score for screening sleep-disordered breathing. J Thorac Dis 10(8):4774CrossRef
19.
Zurück zum Zitat UÇar Z, Batum Ö, Orman M (2020) Validation of the NoSAS score for screening sleep disordered breathing; a sleep clinic-based study in Turkey. Turk J Med Sci UÇar Z, Batum Ö, Orman M (2020) Validation of the NoSAS score for screening sleep disordered breathing; a sleep clinic-based study in Turkey. Turk J Med Sci
20.
Zurück zum Zitat Giampá SQ, Pedrosa RP, Gonzaga CC et al (2018) Performance of NoSAS score versus Berlin questionnaire for screening obstructive sleep apnoea in patients with resistant hypertension. J Hum Hypertens 32(7):518–523CrossRef Giampá SQ, Pedrosa RP, Gonzaga CC et al (2018) Performance of NoSAS score versus Berlin questionnaire for screening obstructive sleep apnoea in patients with resistant hypertension. J Hum Hypertens 32(7):518–523CrossRef
21.
Zurück zum Zitat Guichard K, Marti-Soler H, Micoulaud-Franchi J-A et al (2018) The NoSAS score: a new and simple screening tool for obstructive sleep apnea syndrome in depressive disorder. J Affect Disord 227:136–140CrossRef Guichard K, Marti-Soler H, Micoulaud-Franchi J-A et al (2018) The NoSAS score: a new and simple screening tool for obstructive sleep apnea syndrome in depressive disorder. J Affect Disord 227:136–140CrossRef
22.
Zurück zum Zitat Costa JC, Rebelo-Marques A, Machado J et al (2019) Validation of NoSAS (Neck, Obesity, Snoring, Age, Sex) score as a screening tool for obstructive sleep apnea: analysis in a sleep clinic. Pulmonology 25(5):263–270CrossRef Costa JC, Rebelo-Marques A, Machado J et al (2019) Validation of NoSAS (Neck, Obesity, Snoring, Age, Sex) score as a screening tool for obstructive sleep apnea: analysis in a sleep clinic. Pulmonology 25(5):263–270CrossRef
23.
Zurück zum Zitat Dancey DR, Hanly PJ, Soong C, Lee B, Shepard J Jr, Hoffstein V (2003) Gender differences in sleep apnea: the role of neck circumference. Chest 123(5):1544–1550CrossRef Dancey DR, Hanly PJ, Soong C, Lee B, Shepard J Jr, Hoffstein V (2003) Gender differences in sleep apnea: the role of neck circumference. Chest 123(5):1544–1550CrossRef
24.
Zurück zum Zitat Shah N, Hanna DB, Teng Y et al (2016) Sex-specific prediction models for sleep apnea from the Hispanic Community Health Study/Study of Latinos. Chest 149(6):1409–1418CrossRef Shah N, Hanna DB, Teng Y et al (2016) Sex-specific prediction models for sleep apnea from the Hispanic Community Health Study/Study of Latinos. Chest 149(6):1409–1418CrossRef
25.
Zurück zum Zitat Abrishami A, Khajehdehi A, Chung F (2010) A systematic review of screening questionnaires for obstructive sleep apnea. Can J Anesth 57(5):423–438CrossRef Abrishami A, Khajehdehi A, Chung F (2010) A systematic review of screening questionnaires for obstructive sleep apnea. Can J Anesth 57(5):423–438CrossRef
26.
Zurück zum Zitat Basoglu OK, Tasbakan MS (2018) Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath 22(1):241–249CrossRef Basoglu OK, Tasbakan MS (2018) Gender differences in clinical and polysomnographic features of obstructive sleep apnea: a clinical study of 2827 patients. Sleep Breath 22(1):241–249CrossRef
27.
Zurück zum Zitat Valipour A, Lothaller H, Rauscher H, Zwick H, Burghuber OC, Lavie P (2007) Gender-related differences in symptoms of patients with suspected breathing disorders in sleep: a clinical population study using the sleep disorders questionnaire. Sleep 30(3):312–319CrossRef Valipour A, Lothaller H, Rauscher H, Zwick H, Burghuber OC, Lavie P (2007) Gender-related differences in symptoms of patients with suspected breathing disorders in sleep: a clinical population study using the sleep disorders questionnaire. Sleep 30(3):312–319CrossRef
28.
Zurück zum Zitat Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G (2013) Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol 62(7):569–576CrossRef Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G (2013) Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol 62(7):569–576CrossRef
29.
Zurück zum Zitat Berry RB, Budhiraja R, Gottlieb DJ et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events: deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 8(5):597–619CrossRef Berry RB, Budhiraja R, Gottlieb DJ et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events: deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 8(5):597–619CrossRef
Metadaten
Titel
A meta-analysis of the diagnostic value of NoSAS in patients with sleep apnea syndrome
verfasst von
Huimin Chen
Zhenzhen Zheng
Riken Chen
Yu Zeng
Nanhong Li
Jinru Zhu
Yue Zhong
Haimin Liu
Jianmin Lu
Nuofu Zhang
Cheng Hong
Publikationsdatum
09.06.2021
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 2/2022
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-021-02410-3

Weitere Artikel der Ausgabe 2/2022

Sleep and Breathing 2/2022 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.