Background
Gastric carcinoma is a highly prevalent malignant tumor in clinical practice, with a high invasiveness and metastatic rate; it is the fifth most common cancer in the world [
1]. Its morbidity and mortality rate rank second and third, respectively, in China [
2]. With the improvements made in laparoscopic technology, laparoscopic total gastrectomy (LTG) is the procedure of choice for the treatment of advanced gastric cancer. However, the choice of alimentary tract reconstruction method following total gastrectomy depends on the postoperative recovery and long-term life quality of patients and has traditionally been the focus of clinical research [
3]. Complications associated with total gastrectomy, including reflux esophagitis, anastomotic leakage, anastomotic hemorrhage, and anastomotic stenosis, are the primary factors limiting patient recovery following surgery and may even lead to unplanned repeat surgery or death [
4]. There are numerous methods for reconstructing the alimentary tract after a total gastrectomy [
5], and each procedure has its own advantages. However, a consensus has not yet been reached as to which method is superior [
6]. Using meta-analysis, we examined the optimal surgical technique for alimentary tract reconstruction following total gastrectomy based on the literature on the most prevalent methods utilized in clinical practice (esophageal jejunal Roux-en-Y anastomosis and jejunal interposition). In esophageal jejunal Roux-en-Y anastomosis [
6], the duodenal stump was closed, the lower end of the esophagus was anastomosed with the distal jejunum, and the continuous broken end of the duodenum was anastomosed with the output end of the jejunum in y-style. Jejunal interposition is more common in China but is not very common in the West. The interleaved jejunum is a section of jejunum used in the operation. The upper end is anastomosed with the esophagus, and the lower end is anastomosed with the pancreatoduodenum. In the middle of the jejunum, the anastomosis is opened to the postoperative residual stomach. This is equivalent to the establishment of a jejunal tee between the esophagus, the remnant stomach, and the intestine. Intermediate jejunum has a certain food storage function [
6].
Data and method
Literature search strategy
As of April 2022, we searched the published literature on alimentary tract reconstruction following total gastrectomy on PubMed, Cochrane Library, Embase, China Academic Journals Network Full-text Database (CNKI), and Wanfang Database. In addition, we conducted an exhaustive search based on the reference list. The language of the search was not limited. The search terms were “gastrectomy,” “Roux-en-Y,” “interposition,” “total gastrectomy,” and “jejunal interposition.”
Inclusion and exclusion criteria
Inclusion criteria
(1) The study type was set as a randomized controlled trial (RCT); (2) the included participants were all gastric cancer patients who underwent selective total gastrectomy and alimentary reconstruction—either Roux-en-Y anastomosis or jejunal interposition; (3) none of the patients underwent treatments such as radiotherapy or chemotherapy prior to surgery, which could have affected the outcome; (4) the literature compared Roux-en-Y and “P”-shape jejunal interposition (PJI); (5) the study should have close follow-up and detailed clinical data, and the endpoint event should be derivable from the original data.
Exclusion criteria
(1) Reviews, expert recommendations, meta-analysis, case reports, animal experiments, and cadavers; (2) few cases included in any group of the literature (< 10 cases); (3) patients with distant metastases, recurrent tumors, or other systemic malignancies; (4) literature that did not have any outcome indicators; (5) there were obvious differences in postoperative treatments; (6) repetitive literature; (7) literature where the original text could not be retrieved.
Outcome indicators
The outcome indicators mainly included the occurrence of postoperative complications and nutritional indicators of patients.
Literature screening and data extraction
According to the defined inclusion and exclusion criteria, two independent reviewers separately evaluated the literature, and a senior investigator made the final determination in cases of disagreement. Two individuals independently appraised the extracted literature, and the pertinent data mostly consisted of study characteristics, basic patient data, surgery-related outcome indicators, postoperative complication outcome index, and postoperative nutrition index.
Literature quality evaluation
The literature was independently evaluated by two researchers and the quality assessment of RCTs was typically completed using the Risk of Bias tool developed by the Cochrane Collaboration.
Statistical analysis
Statistical analysis was performed using RevMan 5.4 software. The mean difference (MD) was used as the effect index for the measurement data, and the odds ratio (OR) was used as the effect index for the counting data. The point estimate and 95% CI were calculated for each effect size. The chi-square test was used to determine the heterogeneity between the results of the study (test level was α = 0.1). Also, the heterogeneity was determined by the combination of the I2 value. For studies with no statistical heterogeneity, the fixed-effect model was adopted for pooled analysis. For studies with statistical heterogeneity, the random-effects model was adopted for pooled analysis. Significant clinical heterogeneity was processed using methods such as subgroup analysis or sensitivity analysis, or only descriptive analysis. The test level for meta-analysis was α = 0.05.
Discussion
Gastric cancer is one of the most prevalent malignant tumors in China. As a result of dietary and lifestyle changes, the incidence of gastric cancer is increasing annually, the affected population is getting younger, [
31] and the mortality rate is approximately 75%. The current standard treatment method for advanced gastric cancer is total gastrectomy, which has been performed for more than a century. After a total gastrectomy, the patient may experience loss of appetite or decreased food intake, resulting in severe malnutrition. Consequently, the reconstruction of the alimentary tract following a total gastrectomy is a major concern. Currently, there is no consensus on the alimentary tract reconstruction method following total gastrectomy. The traditional esophageal jejunal Roux-en-Y anastomosis is often preferred due to its simple procedure and effectiveness in improving postoperative reflux. The complications after esophageal jejunal Roux-en-Y anastomosis include anastomotic leakage, empyema, subdiaphragmatic abscess, and postoperative intestinal obstruction. However, the issue of nutrient absorption after total gastrectomy is a matter of concern. To improve the long-term life quality of patients, jejunal interposition that preserves the duodenum is preferred. Roux-en-Y anastomosis transected jejunum, which damaged the integrity of conduction between the intestinal tract and related nerves, and food did not pass through the duodenum, which interfered with normal digestion and absorption function. Compared with the traditional Roux-en-Y anastomosis, the interposition jejunal gastroreplacement operation did not completely cut the jejunum during the operation, so as to maintain the integrity of the patient’s intestinal physiology and nerve conduction, and to preserve the patient’s digestive tract function to the greatest extent, so as to avoid postoperative reflux esophagitis. The physiological function of the duodenum is preserved, which is conducive to promoting the secretion of cholecystokinin and pancreatic fluid, and provides a good intestinal alkaline environment for patients, which effectively reduces the occurrence probability of retention syndrome and anastomotic leakage, and also plays an important role in the growth of intestinal mucosa. This operation can effectively improve the quality of life of patients after surgery. However, jejunal interposition is a relatively complex procedure, involves a longer operation time, and correspondingly has an increased risk of postoperative complications. Its complications include anastomotic leakage, anastomotic hemorrhage, anastomotic stenosis, intestinal obstruction, infection, obstruction of jejunal bag emptying, reflux esophagitis, R-S syndrome, dumping syndrome, early fullness, gallstones, bile reflux, Roux-en-Y retention syndrome, anemia, malnutrition, etc. Although there are several controversies, a vast number of clinical studies have been conducted on this topic. However, there is a lack of large-scale, multi-center, prospective RCTs. Publication bias was frequently observed in studies, and there is still no consensus on the reconstruction method of the alimentary tract following total gastrectomy.
The results of this study revealed that compared with Roux-en-Y anastomosis, patients who underwent jejunal interposition after total gastrectomy had lower incidence of reflux esophagitis and dumping syndrome; higher prognostic nutritional index, postoperative hemoglobin, albumin, and total protein levels; and less changes in postoperative body mass; however, the operation time was relatively longer in the jejunal interposition group. There was no significant difference in intraoperative blood loss between the two groups.
However, one thing that must be brought to our attention is that jejunal interposition is usually a three-anastomoses technique, which potentially increases the overall risk of leakage and other anastomotic complications when compared to a two-anastomoses technique such as the Roux-en-Y. So we should pay more attention to this point in clinical practice and in future studies.
There are certain limitations to this study. First, the sample sizes of some of the studies included in this meta-analysis were small, which may have affected the results. Second, the research was conducted in a single center and there were insufficient measurement indicators in some of the included studies, which may have affected the strength of the results. Third, there may be a distribution bias as studies in other languages were not included. Fourth, the vast majority of the studies in this field come from China and its respective patient population, which could cause bias. Finally, with the development of total gastrectomy and the rapid adoption of laparoscopic techniques, traditional open surgery and laparoscopic surgery may have also had an impact on the outcome.
Conclusion
In conclusion, compared with Roux-en-Y anastomosis, jejunal interposition not only effectively prevents postoperative complications, but also has significant advantages in improving long-term prognosis and life quality of patients, making it a safe and effective method for reconstructing the alimentary tract. However, there is still no consensus on how to reconstruct the alimentary tract following total gastrectomy, and there is a need for a substantial number of clinical cases to resolve the same.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit
http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (
http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.