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01.11.2014 | Review

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

verfasst von: Jason W.-L. Eng, Kathleen M. Kokolus, Chelsey B. Reed, Bonnie L. Hylander, Wen W. Ma, Elizabeth A. Repasky

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2014

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Abstract

Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in unabated production of stress hormones, especially catecholamines, which can have detrimental health effects. While the long-term effects of chronic stress have well-known physiological consequences, recent discoveries have revealed that stress may affect therapeutic efficacy in cancer. Growing epidemiological evidence reveals strong correlations between progression-free and long-term survival and β-blocker usage in cancer patients. In this review, we summarize the current understanding of how the catecholamines, epinephrine and norepinephrine, affect cancer cell survival and tumor progression. We also highlight new data exploring the potential contributions of stress to immunosuppression in the tumor microenvironment and the implications of these findings for the efficacy of immunotherapies.

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Titel: A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response
verfasst von: Jason W.-L. Eng
Kathleen M. Kokolus
Chelsey B. Reed
Bonnie L. Hylander
Wen W. Ma
Elizabeth A. Repasky
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 11/2014
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-014-1617-9

Springer Medizin

A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Abstract

Neu im Fachgebiet Onkologie

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Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

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ICI-Therapie in der Schwangerschaft wird gut toleriert

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Springer Medizin

Abstract

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