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Immunologic Research

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08.06.2018 | Interpretive Synthesis Review Article

A new theory on autoimmunity with reference to multiple sclerosis

verfasst von: Bjørn A. Nexø

Erschienen in: Immunologic Research | Ausgabe 3/2018

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Abstract

Recent genetic evidence points towards endogenous retroviruses as playing a pivotal role in the causation of multiple sclerosis and possibly other autoimmune diseases. We discuss various ways in which this association could be brought about. Specifically, we suggest that two endogenous retroviruses, HERV-Fc1 and HERV-K13, on chromosomes X and 19, respectively, contribute to the development of autoimmune T cells by transforming them in multiple sclerosis. Partially overlapping sets of endogenous retroviruses may play a role in other autoimmune diseases. If this theory holds true, many scientists may have looked for viruses in the wrong tissue. Ir would also explain why lymphocyte-suppressive agents suppress multiple sclerosis.

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Titel: A new theory on autoimmunity with reference to multiple sclerosis
verfasst von: Bjørn A. Nexø
Publikationsdatum: 08.06.2018
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 3/2018
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-018-9003-x

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A new theory on autoimmunity with reference to multiple sclerosis

Abstract

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