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02.02.2019 | Original Contributions

A Novel Full Sense Device to Treat Obesity in a Porcine Model: Preliminary Results

Zeitschrift:
Obesity Surgery
Autoren:
Jung-Hoon Park, Nader Bakheet, Hee Kyong Na, Jae Yong Jeon, Sung Hwan Yoon, Kun Yung Kim, Wang Zhe, Do Hoon Kim, Hwoon-Yong Jung, Ho-Young Song
Wichtige Hinweise
Jung-Hoon Park, Nader Bakheet, Hwoon-Yong Jung and Ho-Young Song contributed equally to this work.
Jung-Hoon Park and Nader Bakheet are the co-first authors.

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Abstract

Purpose

To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model.

Materials and Methods

The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks.

Results

FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig.

Conclusion

FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.

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