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Erschienen in:
01.02.2012 | Original Article
A Randomized Controlled Trial Comparing Two Different Antibiotic Regimens for Prophylaxis at Cesarean Section
Erschienen in: The Journal of Obstetrics and Gynecology of India | Ausgabe 1/2012
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Objectives
To compare the efficacy of intravenous single dose, less costly cefotaxime and more expensive amoxycillin–clavulanic acid combination for prophylaxis at cesarean section.
Method
A double blind randomized controlled trial was undertaken on 760 subjects with two parallel treatment groups. Data were analyzed using Graphpad Instat 3 McIntosh software by Student’s t test, Mann–Whitney U test, the Chi-squared test or fisher’s exact test.
Results
Comparatively narrow spectrum low cost cefotaxime is as effective as more expensive commonly used amoxicillin–clavulanic acid with no significant difference of infectious morbidity and hospital stay (p = 0.27 and 0.11 in elective and emergency cases respectively).
Conclusion
Less costly cefotaxime should be preferred compared to more costly amoxicillin–clavulanic acid combination for prophylaxis at cesarean section.