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Erschienen in: Infection 1/2019

01.10.2018 | Review

A review on anti-adhesion therapies of bacterial diseases

verfasst von: Arezoo Asadi, Shabnam Razavi, Malihe Talebi, Mehrdad Gholami

Erschienen in: Infection | Ausgabe 1/2019

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Abstract

Background

Infections caused by bacteria are a foremost cause of morbidity and mortality in the world. The common strategy of treating bacterial infections is by local or systemic administration of antimicrobial agents. Currently, the increasing antibiotic resistance is a serious and global problem. Since the most important agent for infection is bacteria attaching to host cells, hence, new techniques and attractive approaches that interfere with the ability of the bacteria to adhere to tissues of the host or detach them from the tissues at the early stages of infection are good therapeutic strategies.

Methods

All available national and international databanks were searched using the search keywords. Here, we review various approaches to anti-adhesion therapy, including use of receptor and adhesion analogs, dietary constituents, sublethal concentrations of antibiotics, and adhesion-based vaccines.

Results

Altogether, the findings suggest that interference with bacterial adhesion serves as a new means to fight infectious diseases.

Conclusion

Anti-adhesion-based therapies can be effective in prevention and treatment of bacterial infections, but further work is needed to elucidate underlying mechanisms.
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Metadaten
Titel
A review on anti-adhesion therapies of bacterial diseases
verfasst von
Arezoo Asadi
Shabnam Razavi
Malihe Talebi
Mehrdad Gholami
Publikationsdatum
01.10.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Infection / Ausgabe 1/2019
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-018-1222-5

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Gerade bei aggressiven Malignomen wie dem duktalen Adenokarzinom des Pankreas könnte Früherkennung die Therapiechancen verbessern. Noch jedoch klafft hier eine Lücke. Ein Studienteam hat einen Weg gesucht, sie zu schließen.

Battle of Experts: Sport vs. Spritze bei Adipositas und Typ-2-Diabetes

11.05.2024 DDG-Jahrestagung 2024 Kongressbericht

Im Battle of Experts traten zwei Experten auf dem Diabeteskongress gegeneinander an: Die eine vertrat die Auffassung „Sport statt Spritze“ bei Adipositas und Typ-2-Diabetes, der andere forderte „Spritze statt Sport!“ Am Ende waren sie sich aber einig: Die Kombination aus beidem erzielt die besten Ergebnisse.

Update Innere Medizin

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