nach oben

Cancer and Metastasis Reviews

Erschienen in:

24.01.2020 | Care

A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation

verfasst von: Ulrich Paetow, Peter Bader, Wassim Chemaitilly

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Hematopoietic stem cell transplantation (HSCT) is used in children to treat a variety of malignant and nonmalignant hematologic conditions and certain inborn errors of metabolism. Survivors of HSCT are markedly affected by disease and treatment toxicity. Endocrine complications are among the most commonly reported chronic health conditions in this population. In this review, we summarize the most common endocrine late effects after pediatric HSCT. We also highlight the importance of systematic and longitudinal evaluations to achieve early diagnoses and treatment for these conditions and improve the long-term health outcomes for patients who received HSCT as children.

Gyurkocza, B., & Sandmaier, B. M. (2014). Conditioning regimens for hematopoietic cell transplantation: One size does not fit all. Blood, 124(3), 344–353. https://doi.org/10.1182/blood-2014-02-514778.CrossRefPubMedPubMedCentral

Ruutu, T., Gratwohl, A., de Witte, T., Afanasyev, B., Apperley, J., Bacigalupo, A., Dazzi, F., Dreger, P., Duarte, R., Finke, J., Garderet, L., Greinix, H., Holler, E., Kröger, N., Lawitschka, A., Mohty, M., Nagler, A., Passweg, J., Ringdén, O., Socié, G., Sierra, J., Sureda, A., Wiktor-Jedrzejczak, W., Madrigal, A., & Niederwieser, D. (2014). Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. Bone Marrow Transplantation, 49(2), 168–173. https://doi.org/10.1038/bmt.2013.107.CrossRefPubMed

Eissa, H. M., Lu, L., Baassiri, M., Bhakta, N., Ehrhardt, M. J., Triplett, B. M., Green, D. M., Mulrooney, D. A., Robison, L. L., Hudson, M. M., & Ness, K. K. (2017). Chronic disease burden and frailty in survivors of childhood HSCT: A report from the St. Jude lifetime cohort study. Blood Adv, 1(24), 2243–2246. https://doi.org/10.1182/bloodadvances.2017010280.CrossRefPubMedPubMedCentral

Armenian, S. H., Sun, C. L., Kawashima, T., Arora, M., Leisenring, W., Sklar, C. A., Baker, K. S., Francisco, L., Teh, J. B., Mills, G., Wong, F. L., Rosenthal, J., Diller, L. R., Hudson, M. M., Oeffinger, K. C., Forman, S. J., Robison, L. L., & Bhatia, S. (2011). Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: A report from the bone marrow transplant survivor study (BMTSS) and childhood Cancer survivor study (CCSS). Blood, 118(5), 1413–1420. https://doi.org/10.1182/blood-2011-01-331835.CrossRefPubMedPubMedCentral

Hows, J. M., Passweg, J. R., Tichelli, A., Locasciulli, A., Szydlo, R., Bacigalupo, A., et al. (2006). Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donors. Bone Marrow Transplant, 38(12), 799–805. https://doi.org/10.1038/sj.bmt.1705531.CrossRefPubMed

Leung, W., Ahn, H., Rose, S. R., Phipps, S., Smith, T., Gan, K., et al. (2007). A prospective cohort study of late sequelae of pediatric allogeneic hematopoietic stem cell transplantation. Medicine (Baltimore), 86(4), 215–224. https://doi.org/10.1097/MD.0b013e31812f864d.CrossRef

Baker, K. S., Ness, K. K., Weisdorf, D., Francisco, L., Sun, C. L., Forman, S., et al. (2010, Leukemia). Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: A report from the bone marrow transplant survivor study., 24(12), 2039–2047. https://doi.org/10.1038/leu.2010.210.

Thomas, B. C., Stanhope, R., Plowman, P. N., & Leiper, A. D. (1993). Endocrine function following single fraction and fractionated total body irradiation for bone marrow transplantation in childhood. Acta Endocrinol.(Copenh), 128(6), 508–512.CrossRef

Chemaitilly, W., Boulad, F., Heller, G., Kernan, N. A., Small, T. N., O'Reilly, R. J., et al. (2007). Final height in pediatric patients after hyperfractionated total body irradiation and stem cell transplantation. Bone Marrow Transplant, 40(1), 29–35. https://doi.org/10.1038/sj.bmt.1705694.CrossRefPubMed

10.

Barfield, R. C., Kasow, K. A., & Hale, G. A. (2008). Advances in pediatric hematopoietic stem cell transplantation. Cancer Biology & Therapy, 7(10), 1533–1539.CrossRef

11.

Baird, K., Cooke, K., & Schultz, K. R. (2010). Chronic graft-versus-host disease (GVHD) in children. Pediatric Clinics of North America, 57(1), 297–322. https://doi.org/10.1016/j.pcl.2009.11.003.CrossRefPubMedPubMedCentral

12.

Shalitin, S., Phillip, M., Stein, J., Goshen, Y., Carmi, D., & Yaniv, I. (2006). Endocrine dysfunction and parameters of the metabolic syndrome after bone marrow transplantation during childhood and adolescence. Bone Marrow Transplant, 37(12), 1109–1117. https://doi.org/10.1038/sj.bmt.1705374.CrossRefPubMed

13.

Vantyghem, M. C., Cornillon, J., Decanter, C., Defrance, F., Karrouz, W., Leroy, C., le Mapihan, K., Couturier, M. A., de Berranger, E., Hermet, E., Maillard, N., Marcais, A., Francois, S., Tabrizi, R., Yakoub-Agha, I., & Société Française de Thérapie Cellulaire. (2014). Management of endocrino-metabolic dysfunctions after allogeneic hematopoietic stem cell transplantation. Orphanet Journal of Rare Diseases, 9, 162. https://doi.org/10.1186/s13023-014-0162-0.CrossRefPubMedPubMedCentral

14.

Chemaitilly, W., & Sklar, C. A. (2007). Endocrine complications of hematopoietic stem cell transplantation. Endocrinol.Metab Clin.North Am., 36(4), 983–998. https://doi.org/10.1016/j.ecl.2007.07.002.CrossRefPubMed

15.

Dvorak, C. C., Gracia, C. R., Sanders, J. E., Cheng, E. Y., Baker, K. S., Pulsipher, M. A., et al. (2011). NCI, NHLBI/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: Endocrine challenges-thyroid dysfunction, growth impairment, bone health, & reproductive risks. Biol.Blood Marrow Transplant., 17(12), 1725–1738. https://doi.org/10.1016/j.bbmt.2011.10.006.CrossRefPubMedPubMedCentral

16.

Cohen, A., Bekassy, A. N., Gaiero, A., Faraci, M., Zecca, S., Tichelli, A., et al. (2008). Endocrinological late complications after hematopoietic SCT in children. Bone Marrow Transplant, 41(Suppl 2), S43–S48. https://doi.org/10.1038/bmt.2008.54.CrossRefPubMed

17.

Clement-de, B. A., Oostdijk, W., Van Weel-Sipman, M. H., Van den Broeck, J., Wit, J. M., & Vossen, J. M. (1996). Final height and hormonal function after bone marrow transplantation in children. J.Pediatr., 129(4), 544–550.CrossRef

18.

Sanders, J. E., Guthrie, K. A., Hoffmeister, P. A., Woolfrey, A. E., Carpenter, P. A., & Appelbaum, F. R. (2005). Final adult height of patients who received hematopoietic cell transplantation in childhood. Blood, 105(3), 1348–1354. https://doi.org/10.1182/blood-2004-07-2528.CrossRefPubMed

19.

Brauner, R., Fontoura, M., Zucker, J. M., Devergie, A., Souberbielle, J. C., Prevot-Saucet, C., Michon, J., Gluckman, E., Griscelli, C., & Fischer, A. (1993). Growth and growth hormone secretion after bone marrow transplantation. Arch.Dis.Child, 68(4), 458–463.CrossRef

20.

Rose, S. R., Lustig, R. H., Pitukcheewanont, P., Broome, D. C., Burghen, G. A., Li, H., et al. (1999). Diagnosis of hidden central hypothyroidism in survivors of childhood cancer. J.Clin.Endocrinol.Metab, 84(12), 4472–4479. https://doi.org/10.1210/jcem.84.12.6097.CrossRefPubMed

21.

Sanders, J. E., Pritchard, S., Mahoney, P., Amos, D., Buckner, C. D., Witherspoon, R. P., Deeg, H. J., Doney, K. C., Sullivan, K. M., & Appelbaum, F. R. (1986). Growth and development following marrow transplantation for leukemia. Blood, 68(5), 1129–1135.CrossRef

22.

Ogilvy-Stuart, A. L., Clark, D. J., Wallace, W. H., Gibson, B. E., Stevens, R. F., Shalet, S. M., & Donaldson, M. D. (1992). Endocrine deficit after fractionated total body irradiation. Arch.Dis.Child, 67(9), 1107–1110.CrossRef

23.

Michel, G., Socie, G., Gebhard, F., Bernaudin, F., Thuret, I., Vannier, J. P., et al. (1997). Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: The impact of conditioning regimen without total-body irradiation--a report from the Societe Francaise de Greffe de Moelle. J.Clin.Oncol., 15(6), 2238–2246.CrossRef

24.

Berger, C., Le-Gallo, B., Donadieu, J., Richard, O., Devergie, A., Galambrun, C., et al. (2005). Late thyroid toxicity in 153 long-term survivors of allogeneic bone marrow transplantation for acute lymphoblastic leukaemia. Bone Marrow Transplant, 35(10), 991–995. https://doi.org/10.1038/sj.bmt.1704945.CrossRefPubMed

25.

Sklar, C. A., Kim, T. H., & Ramsay, N. K. (1982). Thyroid dysfunction among long-term survivors of bone marrow transplantation. Am.J.Med., 73(5), 688–694. https://doi.org/10.1016/0002-9343(82)90411-9.CrossRefPubMed

26.

Boulad, F., Bromley, M., Black, P., Heller, G., Sarafoglou, K., Gillio, A., et al. (1995). Thyroid dysfunction following bone marrow transplantation using hyperfractionated radiation. Bone Marrow Transplantation, 15(1), 71–76.PubMed

27.

Sklar, C., Boulad, F., Small, T., & Kernan, N. (2001). Endocrine complications of pediatric stem cell transplantation. Frontiers in Bioscience, 6, G17–G22.CrossRef

28.

Cohen, A., Rovelli, A., Merlo, D. F., van Lint, M. T., Lanino, E., Bresters, D., et al. (2007). Risk for secondary thyroid carcinoma after hematopoietic stem-cell transplantation: An EBMT late effects working party study. J.Clin.Oncol., 25(17), 2449–2454. https://doi.org/10.1200/JCO.2006.08.9276.CrossRefPubMed

29.

Afify, Z., Shaw, P. J., Clavano-Harding, A., & Cowell, C. T. (2000). Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/cyclophosphamide. Bone Marrow Transplant., 25(10), 1087–1092. https://doi.org/10.1038/sj.bmt.1702384.CrossRefPubMed

30.

Sarafoglou, K., Boulad, F., Gillio, A., & Sklar, C. (1997). Gonadal function after bone marrow transplantation for acute leukemia during childhood. J. Pediatr., 130(2), 210–216. https://doi.org/10.1016/s0022-3476(97)70345-7.CrossRefPubMed

31.

Matsumoto, M., Shinohara, O., Ishiguro, H., Shimizu, T., Hattori, K., Ichikawa, M., et al. (1999). Ovarian function after bone marrow transplantation performed before menarche. Arch. Dis. Child, 80(5), 452–454.CrossRef

32.

Sanders, J. E., Buckner, C. D., Amos, D., Levy, W., Appelbaum, F. R., Doney, K., Storb, R., Sullivan, K. M., Witherspoon, R. P., & Thomas, E. D. (1988). Ovarian function following marrow transplantation for aplastic anemia or leukemia. J.Clin.Oncol., 6(5), 813–818.CrossRef

33.

Anderson, R. A., Mitchell, R. T., Kelsey, T. W., Spears, N., Telfer, E. E., & Wallace, W. H. (2015). Cancer treatment and gonadal function: Experimental and established strategies for fertility preservation in children and young adults. Lancet Diabetes Endocrinol, 3(7), 556–567. https://doi.org/10.1016/S2213-8587(15)00039-X.CrossRefPubMed

34.

Nakagawa, K., Kanda, Y., Yamashita, H., Nakagawa, S., Sasano, N., Ohtomo, K., et al. (2008). Ovarian shielding allows ovarian recovery and normal birth in female hematopoietic SCT recipients undergoing TBI. Bone Marrow Transplant, 42(10), 697–699. https://doi.org/10.1038/bmt.2008.234.CrossRefPubMed

35.

Assouline, E., Crocchiolo, R., Prebet, T., Broussais, F., Coso, D., Gamerre, M., et al. (2013). Impact of reduced-intensity conditioning allogeneic stem cell transplantation on women's fertility. Clinical Lymphoma, Myeloma & Leukemia, 13(6), 704–710. https://doi.org/10.1016/j.clml.2013.05.014.CrossRef

36.

Sanders, J. E., Hawley, J., Levy, W., Gooley, T., Buckner, C. D., Deeg, H. J., Doney, K., Storb, R., Sullivan, K., Witherspoon, R., & Appelbaum, F. R. (1996). Pregnancies following high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation. Blood, 87(7), 3045–3052.CrossRef

37.

Bath, L. E., Critchley, H. O., Chambers, S. E., Anderson, R. A., Kelnar, C. J., & Wallace, W. H. (1999). Ovarian and uterine characteristics after total body irradiation in childhood and adolescence: Response to sex steroid replacement. Br.J.Obstet.Gynaecol., 106(12), 1265–1272.CrossRef

38.

Anserini, P., Chiodi, S., Spinelli, S., Costa, M., Conte, N., Copello, F., et al. (2002). Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling. Bone Marrow Transplant, 30(7), 447–451. https://doi.org/10.1038/sj.bmt.1703651.CrossRefPubMed

39.

Rovo, A., Tichelli, A., Passweg, J. R., Heim, D., Meyer-Monard, S., Holzgreve, W., et al. (2006). Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cell transplantation is associated with age, time interval since transplantation, and apparently absence of chronic GvHD. Blood, 108(3), 1100–1105. https://doi.org/10.1182/blood-2006-01-0176.CrossRefPubMed

40.

Ishiguro, H., Yasuda, Y., Tomita, Y., Shinagawa, T., Shimizu, T., Morimoto, T., et al. (2007). Gonadal shielding to irradiation is effective in protecting testicular growth and function in long-term survivors of bone marrow transplantation during childhood or adolescence. Bone Marrow Transplant, 39(8), 483–490. https://doi.org/10.1038/sj.bmt.1705612.CrossRefPubMed

41.

Sklar, C. A., Robison, L. L., Nesbit, M. E., Sather, H. N., Meadows, A. T., Ortega, J. A., et al. (1990). Effects of radiation on testicular function in long-term survivors of childhood acute lymphoblastic leukemia: A report from the children Cancer study group. J.Clin.Oncol., 8(12), 1981–1987.CrossRef

42.

Kaste, S. C., Shidler, T. J., Tong, X., Srivastava, D. K., Rochester, R., Hudson, M. M., et al. (2004). Bone mineral density and osteonecrosis in survivors of childhood allogeneic bone marrow transplantation. Bone Marrow Transplant, 10.1038/sj.bmt.1704360, 33(4), 435–441.

43.

Mostoufi-Moab, S., & Ward, L. M. (2018). Skeletal morbidity in children and adolescents during and following Cancer therapy. Hormone Research in Pædiatrics, 1–15. https://doi.org/10.1159/000494809.

44.

Mostoufi-Moab, S., Magland, J., Isaacoff, E. J., Sun, W., Rajapakse, C. S., Zemel, B., et al. (2015). Adverse fat depots and marrow adiposity are associated with skeletal deficits and insulin resistance in long-term survivors of pediatric hematopoietic stem cell transplantation. J.Bone Miner.Res., 30(9), 1657–1666. https://doi.org/10.1002/jbmr.2512.CrossRefPubMedPubMedCentral

45.

Taskinen, M., Saarinen-Pihkala, U. M., Hovi, L., & Lipsanen-Nyman, M. (2000). Impaired glucose tolerance and dyslipidaemia as late effects after bone-marrow transplantation in childhood. Lancet, 356(9234), 993–997. https://doi.org/10.1016/S0140-6736(00)02717-3.CrossRefPubMed

46.

Hoffmeister, P. A., Storer, B. E., & Sanders, J. E. (2004). Diabetes mellitus in long-term survivors of pediatric hematopoietic cell transplantation. J.Pediatr.Hematol.Oncol., 26(2), 81–90. https://doi.org/10.1097/00043426-200402000-00003.CrossRefPubMed

47.

Traggiai, C., Stanhope, R., Nussey, S., & Leiper, A. D. (2003). Diabetes mellitus after bone marrow transplantation during childhood. Med.Pediatr.Oncol., 40(2), 128–129. https://doi.org/10.1002/mpo.10098.CrossRefPubMed

48.

Chemaitilly, W., Boulad, F., Oeffinger, K. C., & Sklar, C. A. (2009). Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: A pilot study. Bone Marrow Transplant, 44(6), 339–343. https://doi.org/10.1038/bmt.2009.40.CrossRefPubMed

49.

Montero, N., & Pascual, J. (2015). Immunosuppression and post-transplant hyperglycemia. Current Diabetes Reviews, 11(3), 144–154.CrossRef

50.

Chow, E. J., Liu, W., Srivastava, K., Leisenring, W. M., Hayashi, R. J., Sklar, C. A., et al. (2013). Differential effects of radiotherapy on growth and endocrine function among acute leukemia survivors: A childhood cancer survivor study report. Pediatr.Blood Cancer, 60(1), 110–115. https://doi.org/10.1002/pbc.24198.CrossRefPubMed

51.

Neville, K. A., Cohn, R. J., Steinbeck, K. S., Johnston, K., & Walker, J. L. (2006). Hyperinsulinemia, impaired glucose tolerance, and diabetes mellitus in survivors of childhood cancer: Prevalence and risk factors. J.Clin.Endocrinol.Metab, 91(11), 4401–4407. https://doi.org/10.1210/jc.2006-0128.CrossRefPubMed

52.

Meacham, L. R., Sklar, C. A., Li, S., Liu, Q., Gimpel, N., Yasui, Y., et al. (2009). Diabetes mellitus in long-term survivors of childhood cancer. Increased risk associated with radiation therapy: A report for the childhood cancer survivor study. Arch.Intern.Med., 169(15), 1381–1388. https://doi.org/10.1001/archinternmed.2009.209.CrossRefPubMedPubMedCentral

53.

Wei, C., Thyagiarajan, M. S., Hunt, L. P., Shield, J. P., Stevens, M. C., & Crowne, E. C. (2015). Reduced insulin sensitivity in childhood survivors of haematopoietic stem cell transplantation is associated with lipodystropic and sarcopenic phenotypes. Pediatr.Blood Cancer, 62(11), 1992–1999. https://doi.org/10.1002/pbc.25601.CrossRefPubMed

54.

Wei, C., Thyagiarajan, M., Hunt, L., Cox, R., Bradley, K., Elson, R., et al. (2015). Reduced beta-cell reserve and pancreatic volume in survivors of childhood acute lymphoblastic leukaemia treated with bone marrow transplantation and total body irradiation. Clin.Endocrinol.(Oxf), 82(1), 59–67. https://doi.org/10.1111/cen.12575.CrossRef

55.

de Vathaire, F., El-Fayech, C., Ben Ayed, F. F., Haddy, N., Guibout, C., Winter, D., et al. (2012). Radiation dose to the pancreas and risk of diabetes mellitus in childhood cancer survivors: A retrospective cohort study. The Lancet Oncology, 13(10), 1002–1010. https://doi.org/10.1016/S1470-2045(12)70323-6.CrossRefPubMed

56.

Oudin, C., Simeoni, M. C., Sirvent, N., Contet, A., Begu-Le, C. A., Bordigoni, P., et al. (2011). Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia. Blood, 117(17), 4442–4448. https://doi.org/10.1182/blood-2010-09-304899.CrossRefPubMed

57.

Paris, C., Yates, L., Lama, P., Zepeda, A. J., Gutierrez, D., & Palma, J. (2012). Evaluation of metabolic syndrome after hematopoietic stem cell transplantation in children and adolescents. Pediatric Blood & Cancer, 59(2), 306–310. https://doi.org/10.1002/pbc.24104.CrossRef

58.

Armenian, S. H., Chemaitilly, W., Chen, M., Chow, E. J., Duncan, C. N., Jones, L. W., et al. (2016). National Institutes of Health hematopoietic cell transplantation late effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report. Biol Blood Marrow Transplant, 23, 201. https://doi.org/10.1016/j.bbmt.2016.08.019.CrossRefPubMedPubMedCentral

59.

Turcotte, L. M., Yingst, A., & Verneris, M. R. (2016). Metabolic syndrome after hematopoietic cell transplantation: At the intersection of treatment toxicity and immune dysfunction. Biology of Blood and Marrow Transplantation, 22(7), 1159–1166. https://doi.org/10.1016/j.bbmt.2016.03.016.CrossRefPubMedPubMedCentral

60.

Ness, K. K., Krull, K. R., Jones, K. E., Mulrooney, D. A., Armstrong, G. T., Green, D. M., et al. (2013). Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: A report from the St Jude lifetime cohort study. J.Clin.Oncol., 31(36), 4496–4503. https://doi.org/10.1200/JCO.2013.52.2268.CrossRefPubMedPubMedCentral

61.

Chow, E. J., Anderson, L., Baker, K. S., Bhatia, S., Guilcher, G. M., Huang, J. T., Pelletier, W., Perkins, J. L., Rivard, L. S., Schechter, T., Shah, A. J., Wilson, K. D., Wong, K., Grewal, S. S., Armenian, S. H., Meacham, L. R., Mulrooney, D. A., & Castellino, S. M. (2016). Late effects surveillance recommendations among survivors of childhood hematopoietic cell transplantation: A Children's oncology group report. Biology of Blood and Marrow Transplantation, 22(5), 782–795. https://doi.org/10.1016/j.bbmt.2016.01.023.CrossRefPubMedPubMedCentral

62.

Kremer, L. C., Mulder, R. L., Oeffinger, K. C., Bhatia, S., Landier, W., Levitt, G., et al. (2013). A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: A report from the international late effects of childhood Cancer guideline harmonization group. Pediatr.Blood Cancer, 60(4), 543–549. https://doi.org/10.1002/pbc.24445.CrossRefPubMed

63.

Sklar, C. A., Antal, Z., Chemaitilly, W., Cohen, L. E., Follin, C., Meacham, L. R., et al. (2018). Hypothalamic-pituitary and growth disorders in survivors of childhood Cancer: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 103, 2761. https://doi.org/10.1210/jc.2018-01175.CrossRefPubMed

64.

Sfeir, J. G., Kittah, N. E., Tamhane, S. U., Jasim, S., Chemaitilly, W., Cohen, L., et al. (2018). Diagnosis of growth hormone deficiency as a late effect of radiotherapy in survivors of childhood cancers. The Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2018-01204.

65.

Tamhane, S., Sfeir, J. G., Kittah, N. E. N., Jasim, S., Chemaitilly, W., Cohen, L. E., et al. (2018). Growth hormone therapy in childhood Cancer Survivors: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. https://doi.org/10.1210/jc.2018-01205.

66.

Raman, S., Grimberg, A., Waguespack, S. G., Miller, B. S., Sklar, C. A., Meacham, L. R., et al. (2015). Risk of Neoplasia in pediatric patients receiving growth hormone therapy - a report from the pediatric Endocrine Society drug and therapeutics committee. J.Clin.Endocrinol.Metab. https://doi.org/10.1210/jc.2015-1002.

67.

Leschek, E. W., Rose, S. R., Yanovski, J. A., Troendle, J. F., Quigley, C. A., Chipman, J. J., et al. (2004). Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: A randomized, double-blind, placebo-controlled trial. The Journal of Clinical Endocrinology and Metabolism, 89(7), 3140–3148. https://doi.org/10.1210/jc.2003-031457.CrossRefPubMed

68.

Mauras, N., Ross, J. L., Gagliardi, P., Yu, Y. M., Hossain, J., Permuy, J., Damaso, L., Merinbaum, D., Singh, R. J., Gaete, X., & Mericq, V. (2016). Randomized trial of aromatase inhibitors, growth hormone, or combination in pubertal boys with idiopathic, short stature. The Journal of Clinical Endocrinology and Metabolism, 101(12), 4984–4993. https://doi.org/10.1210/jc.2016-2891.CrossRefPubMedPubMedCentral

69.

Chemaitilly, W., Cohen, L. E., Mostoufi-Moab, S., Patterson, B. C., Simmons, J. H., Meacham, L. R., van Santen, H., & Sklar, C. A. (2018). Endocrine late effects in childhood Cancer survivors. Journal of Clinical Oncology, 36(21), 2153–2159. https://doi.org/10.1200/JCO.2017.76.3268.CrossRefPubMed

70.

Clement, S. C., Kremer, L. C. M., Verburg, F. A., Simmons, J. H., Goldfarb, M., Peeters, R. P., Alexander, E. K., Bardi, E., Brignardello, E., Constine, L. S., Dinauer, C. A., Drozd, V. M., Felicetti, F., Frey, E., Heinzel, A., van den Heuvel-Eibrink, M., Huang, S. A., Links, T. P., Lorenz, K., Mulder, R. L., Neggers, S. J., Nieveen van Dijkum, E., Oeffinger, K. C., van Rijn, R., Rivkees, S. A., Ronckers, C. M., Schneider, A. B., Skinner, R., Wasserman, J. D., Wynn, T., Hudson, M. M., Nathan, P. C., & van Santen, H. (2018). Balancing the benefits and harms of thyroid cancer surveillance in survivors of childhood, adolescent and young adult cancer: Recommendations from the international late effects of childhood Cancer guideline harmonization group in collaboration with the PanCareSurFup consortium. Cancer Treatment Reviews, 63, 28–39. https://doi.org/10.1016/j.ctrv.2017.11.005.CrossRefPubMed

71.

Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., et al. (2015). Management guidelines for children with thyroid nodules and differentiated thyroid Cancer. Thyroid, 25(7), 716–759. https://doi.org/10.1089/thy.2014.0460.CrossRefPubMedPubMedCentral

72.

Cooper, D. S., Doherty, G. M., Haugen, B. R., Kloos, R. T., Lee, S. L., Mandel, S. J., et al. (2009). Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid, 19(11), 1167–1214. https://doi.org/10.1089/thy.2009.0110.CrossRefPubMed

73.

Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018). Testosterone therapy in men with Hypogonadism: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 103(5), 1715–1744. https://doi.org/10.1210/jc.2018-00229.CrossRefPubMed

74.

Palmert, M. R., & Dunkel, L. (2012). Clinical practice. Delayed puberty. The New England Journal of Medicine, 366(5), 443–453. https://doi.org/10.1056/NEJMcp1109290.CrossRefPubMed

75.

Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., et al. (2016). Hormonal replacement in hypopituitarism in adults: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 101(11), 3888–3921. https://doi.org/10.1210/jc.2016-2118.CrossRefPubMed

76.

Moskowitz, C. S., Chou, J. F., Sklar, C. A., Barnea, D., Ronckers, C. M., Friedman, D. N., Neglia, J. P., Turcotte, L., Howell, R. M., Henderson, T. O., Armstrong, G. T., Leisenring, W. M., Robison, L. L., van Leeuwen, F. E., Pike, M. C., & Oeffinger, K. C. (2017). Radiation-associated breast cancer and gonadal hormone exposure: A report from the childhood Cancer survivor study. British Journal of Cancer, 117, 290–299. https://doi.org/10.1038/bjc.2017.169.CrossRefPubMedPubMedCentral

77.

Kenney, L. B., Cohen, L. E., Shnorhavorian, M., Metzger, M. L., Lockart, B., Hijiya, N., et al. (2012). Male reproductive health after childhood, adolescent, and young adult cancers: A report from the Children's oncology group. J.Clin.Oncol, 30(27), 3408–3416. https://doi.org/10.1200/JCO.2011.38.6938.CrossRefPubMedPubMedCentral

78.

Metzger, M. L., Meacham, L. R., Patterson, B., Casillas, J. S., Constine, L. S., Hijiya, N., et al. (2013). Female reproductive health after childhood, adolescent, and young adult cancers: Guidelines for the assessment and management of female reproductive complications. J.Clin.Oncol, 31(9), 1239–1247. https://doi.org/10.1200/JCO.2012.43.5511.CrossRefPubMedPubMedCentral

79.

Alexandroni, H., Shoham, G., Levy-Toledano, R., Nagler, A., Mohty, M., Duarte, R., Leong, M., & Shoham, Z. (2019). Fertility preservation from the point of view of hematopoietic cell transplant specialists-a worldwide-web-based survey analysis. Bone Marrow Transplantation, 54, 1747–1755. https://doi.org/10.1038/s41409-019-0519-z.CrossRefPubMed

80.

Wasilewski-Masker, K., Kaste, S. C., Hudson, M. M., Esiashvili, N., Mattano, L. A., & Meacham, L. R. (2008). Bone mineral density deficits in survivors of childhood cancer: Long-term follow-up guidelines and review of the literature. Pediatrics, 121(3), e705–e713. https://doi.org/10.1542/peds.2007-1396.CrossRefPubMed

81.

Carpenter, P. A., Hoffmeister, P., Chesnut 3rd, C. H., Storer, B., Charuhas, P. M., Woolfrey, A. E., et al. (2007). Bisphosphonate therapy for reduced bone mineral density in children with chronic graft-versus-host disease. Biology of Blood and Marrow Transplantation, 13(6), 683–690. https://doi.org/10.1016/j.bbmt.2007.02.001.CrossRefPubMed

82.

Marini, J. C. (2003). Do bisphosphonates make children's bones better or brittle? The New England Journal of Medicine, 349(5), 423–426. https://doi.org/10.1056/NEJMp038103.CrossRefPubMed

83.

Blaser, B. W., Kim, H. T., Alyea 3rd, E. P., Ho, V. T., Cutler, C., Armand, P., et al. (2012). Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation, 18(4), 575–583. https://doi.org/10.1016/j.bbmt.2011.08.003.CrossRefPubMed

Titel: A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation
verfasst von: Ulrich Paetow
Peter Bader
Wassim Chemaitilly
Publikationsdatum: 24.01.2020
Verlag: Springer US
Schlagwörter: Care
Radiotherapy
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2020
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-020-09864-z

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2020

Genetic predisposition and chromosome instability in neuroblastoma

New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence

Signaling pathways in Rhabdomyosarcoma invasion and metastasis

What are the effects of exercise training in childhood cancer survivors? A systematic review

Clinical research tools in pediatric oncology: challenges and opportunities

Professor Samuel C. Brooks, Jr., Ph.D. (1928–2019)

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie