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01.05.2004 | Original Article

Absence of simian virus 40 DNA sequences in primary central nervous system lymphoma in HIV-negative patients

verfasst von: Manuel Montesinos-Rongen, Razvan Besleaga, Susanne Heinsohn, Reiner Siebert, Hartmut Kabisch, Otmar D. Wiestler, Martina Deckert

Erschienen in: Virchows Archiv | Ausgabe 5/2004

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Abstract

Simian virus 40 (SV40) is known to induce primary brain tumors and lymphomas in animal models. Recently, it was also associated with the pathogenesis of human non-Hodgkin’s lymphomas. In the present study, we investigated primary central nervous system lymphomas (PCNSL), a defined subgroup of diffuse large B-cell lymphoma confined to the central nervous system, for the presence of SV40 DNA. Frozen tissue samples of 23 PCNSL derived from human immunodeficiency virus-negative patients were analyzed by two different, fully nested polymerase chain reaction protocols. SV40 DNA sequences could not be detected in any of these samples. Thus, SV40 can be added to the list of viruses that have already been excluded as pathogenetically relevant cofactors in PCNSL.

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Titel: Absence of simian virus 40 DNA sequences in primary central nervous system lymphoma in HIV-negative patients
verfasst von: Manuel Montesinos-Rongen
Razvan Besleaga
Susanne Heinsohn
Reiner Siebert
Hartmut Kabisch
Otmar D. Wiestler
Martina Deckert
Publikationsdatum: 01.05.2004
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 5/2004
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1001-9

Springer Medizin

Absence of simian virus 40 DNA sequences in primary central nervous system lymphoma in HIV-negative patients

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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