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Clinical Pharmacokinetics
Erschienen in: Clinical Pharmacokinetics 13/2003

01.11.2003 | Review Article

Absorption Enhancers for Nasal Drug Delivery

verfasst von: Professor Stanley S. Davis, Lisbeth Illum

Erschienen in: Clinical Pharmacokinetics | Ausgabe 13/2003

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Abstract

This paper describes the basic concepts for the transmucosal delivery of drugs, and in particular the use of the nasal route for delivery of challenging drugs such as polar low-molecular-weight drugs and peptides and proteins. Strategies for the exploitation of absorption enhancers for the improvement of nasal delivery are discussed, including consideration of mechanisms of action and the correlation between toxic effect and absorption enhancement. Selected enhancer systems, such as cyclodextrins, phospholipids, bioadhesive powder systems and chitosan, are discussed in detail. Examples of the use of these enhancers in preclinical and clinical studies are given. Methods for assessing irritancy and damage to the nasal membrane from the use of absorption enhancers are also described. Finally, the mucosal use of absorption enhancers (chitosan) for the improved nasal delivery of vaccines is reported with reference to recent phase I/II clinical studies.
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Metadaten
Titel
Absorption Enhancers for Nasal Drug Delivery
verfasst von
Professor Stanley S. Davis
Lisbeth Illum
Publikationsdatum
01.11.2003
Verlag
Springer International Publishing
Erschienen in
Clinical Pharmacokinetics / Ausgabe 13/2003
Print ISSN: 0312-5963
Elektronische ISSN: 1179-1926
DOI
https://doi.org/10.2165/00003088-200342130-00003

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