The skin is the largest organ covering the human body. Continuous loss of normal anatomic structures and function of the skin results in a wound [
1,
2]. Based on their wound healing time frames, wounds are classified as acute or chronic. In everyday pathology, wounds remain a challenging clinical problem, with early and late complications representing a frequent cause of morbidity and mortality [
3,
4]. Acute wounds constitute a common health problem, with an estimated 11.8 million wounds treated in emergency departments in the USA annually [
5,
6]. Wounds are typically characterized based on wound depth and the area of skin affected [
7]. According to the degree of skin injury, wounds can be divided into partial-thickness wounds and full-thickness wounds [
8]. There are numerous therapeutic methods used to treat different types of wounds, such as negative pressure wound therapy, bioengineered tissue alternatives, pedicle flaps, and free tissue transfer. Based on the “reconstruction pyramid”, which is a guide for wound healing, treatments are arranged hierarchically, from minimally invasive procedures for small and superficial wounds to highly complex procedures for large, deep, and complex soft tissue defects [
9]. For instance, due to a lack of redundant or pliable surrounding soft tissue, wounds in the foot or ankle often need to be closed with various kinds of flaps. However, surgical flap interventions have associated disadvantages that include secondary damage, poor tissue appearance, and high surgical requirements. For this reason, tissue engineered dressings have better application prospects than flap surgery. Acellular dermal matrix (ADM) is a promising tool for the treatment of soft tissue defects that can maintain an enhanced quality of wound repair [
10‐
12]. In recent years, acellular dermal matrix (ADM) has been used in the treatment of deep tissue defects in combination with split-thickness skin grafts and negative pressure wound therapy [
13,
14]. However, ADM also has the disadvantage that it cannot independently achieve physiological epithelial tissue regeneration and repair [
15]. Here, we found that a porcine acellular dermal matrix can promote complete wound healing.