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Pediatric Radiology

Erschienen in:

01.02.2012 | Original Article

Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children

verfasst von: Maria José Noruegas, Hugo Matos, Isabel Gonçalves, Maria Augusta Cipriano, Conceição Sanches

Erschienen in: Pediatric Radiology | Ausgabe 2/2012

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Abstract

Background

Acoustic radiation force impulse-imaging (ARFI) uses sound waves to interrogate the mechanical stiffness of a tissue.

Objective

To determine the usefulness of ARFI for estimating liver fibrosis in children.

Materials and methods

A prospective masked study of children with chronic liver disease (CLD) and/or before liver transplant (LT) comparing ARFI with histopathological analysis. Children with no history of liver disease served as a control group. ARFI was performed with Virtual Touch software using ACUSON S2000. Share wave velocities (SWV) of several regions within the liver were measured.

Results

Fifty-two children were studied (mean age 8 years; range 1–16 years). The abnormal group included 10 children (31%) with CLD and 22 (69%) planned for LT. There were 20 normal controls. Mean SWV was 1.70 m/s in the abnormal group and 1.19 m/s in the controls. For diagnosis of fibrosis stage ≥ F1, ≥F2 and F4, the areas under the receiver-operator characteristics curves were 0.834, 0.818 and 0.983, respectively.

Conclusion

SWV is related to the degree of liver fibrosis in children, and may be a non-invasive alternative to biopsy.

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Titel: Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children
verfasst von: Maria José Noruegas
Hugo Matos
Isabel Gonçalves
Maria Augusta Cipriano
Conceição Sanches
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: Pediatric Radiology / Ausgabe 2/2012
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-011-2257-2

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Springer Medizin

Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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Springer Medizin

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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