Erschienen in:
01.05.2008 | Poster presentation
Actions of IGF-I are differentially regulated by fatty acids in normal and breast cancer epithelial cells
verfasst von:
CM Perks, AA Morrison, L Zeng, C Jarrett, J Shield, ZE Winters, JMP Holly
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2008
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Excerpt
Obesity will soon be the leading preventable risk factor for many cancers. The insulin-like growth factors (IGFs) have been strongly implicated as important risk factors for many epithelial cancers, including breast cancer, and for mediating the link between nutrition and these cancers. Obesity-related increases in circulating fatty acids cause insulin resistance with consequent morbidity but, despite the considerable overlap between insulin and IGFs, there have been no studies of the effects of fatty acids on IGF activity. …