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09.11.2018 | ORIGINAL ARTICLE

Acute Exposure to Diesel-Biodiesel Particulate Matter Promotes Murine Lung Oxidative Stress by Nrf2/HO-1 and Inflammation Through the NF-kB/TNF-α Pathways

verfasst von: Isabella Cattani-Cavalieri, Samuel Santos Valenca, Manuella Lanzetti, Giovanna Marcella Cavalcante Carvalho, Walter Araújo Zin, Andréa Monte-Alto-Costa, Luís Cristóvão Porto, Bruna Romana-Souza

Erschienen in: Inflammation | Ausgabe 2/2019

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Abstract

Air pollution caused by fuel burning contributes to respiratory impairments that may lead to death. We aimed to investigate the effects of biodiesel (DB) burning in mouse lungs. DB particulate matter was collected from the exhaust pipes of a bus engine. Mice were treated with 250 μg or 1000 μg of DB particulate matter by intranasal instillation over 5 consecutive days. We demonstrated that DB particulate matter penetrated the lung in the 250-μg and 1000-μg groups. In addition, the DB particulate matter number in pulmonary parenchyma was 175-fold higher in the 250-μg group and 300-fold higher in the 1000-μg group compared to control mice. The instillation of DB particulate matter increased the macrophage number and protein levels of TNF-alpha in murine lungs. DB particulate matter enhanced ROS production in both exposed groups and the malondialdehyde levels compared to the control group. The protein expression levels of Nrf2, p-NF-kB, and HO-1 were higher in the 250-μg group and lower in the 1000-μg group than in control mice and the 250-μg group. In conclusion, DB particulate matter instillation promotes oxidative stress by activating the Nrf2/HO-1 and inflammation by p-NF-kB/TNF-alpha pathways.

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Titel: Acute Exposure to Diesel-Biodiesel Particulate Matter Promotes Murine Lung Oxidative Stress by Nrf2/HO-1 and Inflammation Through the NF-kB/TNF-α Pathways
verfasst von: Isabella Cattani-Cavalieri
Samuel Santos Valenca
Manuella Lanzetti
Giovanna Marcella Cavalcante Carvalho
Walter Araújo Zin
Andréa Monte-Alto-Costa
Luís Cristóvão Porto
Bruna Romana-Souza
Publikationsdatum: 09.11.2018
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 2/2019
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-018-0910-8

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Acute Exposure to Diesel-Biodiesel Particulate Matter Promotes Murine Lung Oxidative Stress by Nrf2/HO-1 and Inflammation Through the NF-kB/TNF-α Pathways

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