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Pediatric Nephrology
Erschienen in: Pediatric Nephrology 1/2021

26.07.2020 | Original Article

Acute kidney injury among hospitalized children with cancer

verfasst von: Mengqi Xiong, Long Wang, Licong Su, Weihong Luo, Yanqin Li, Lu Li, Sheng Nie, Fan Fan Hou

Erschienen in: Pediatric Nephrology | Ausgabe 1/2021

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Abstract

Background

Few studies to date have analyzed the epidemiology of acute kidney injury (AKI) in children with cancer in developing countries. The aim of this study was to assess the incidence, risk profile and outcomes of AKI in Chinese children hospitalized with cancer.

Methods

This multi-center study analyzed Chinese children hospitalized with cancer in 2013–2015. Electronic hospital and laboratory databases were screened to select pediatric patients with malignancy who had at least two Scr results within any 7-day window during their first 30 days of hospitalization. AKI events were identified and staged according to Kidney Disease Improving Global Outcomes (KDIGO) criteria. The incidence of and risk factors for AKI were analyzed, as were mortality rate, incidence of kidney recovery, and length of hospital stay.

Results

Of the 9828 children with cancer, 1657 (16.9%) experienced AKI events, including 549 (5.6%) community-acquired (CA-AKI) and 1108 (11.3%) hospital-acquired AKI (HA-AKI) events. The three types of cancer with the highest incidence of AKI were urinary system cancer (25.8%), hepatic cancer (19.4%), and retroperitoneal malignancies (19.1%). The risk factor profiles of CA-AKI and HA-AKI events differed, with many HA-AKI events due to treatment with nephrotoxic agents. In-hospital death rates were 5.4% (90 of 1657) in children with and 0.9% (74 of 8171) in children without AKI events. AKI events were also associated with longer hospitalization and higher daily costs.

Conclusions

AKI events are common among Chinese children hospitalized for cancer and are associated with adverse in-hospital outcomes.
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Metadaten
Titel
Acute kidney injury among hospitalized children with cancer
verfasst von
Mengqi Xiong
Long Wang
Licong Su
Weihong Luo
Yanqin Li
Lu Li
Sheng Nie
Fan Fan Hou
Publikationsdatum
26.07.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 1/2021
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-020-04678-1

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