nach oben

Pediatric Nephrology

Erschienen in:

01.04.2012 | Review

Adiponectin, cardiovascular disease, chronic kidney disease: emerging data on complex interactions

verfasst von: Megan M. Lo, Mark Mitsnefes

Erschienen in: Pediatric Nephrology | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Over the past decade, adiponectin has been a subject of interest in many fields of medicine. The effect of adiponectin in metabolism and inflammation has been described for cardiovascular disease (CVD) in animal studies and the general population, generally as a protective factor. Extensive literature pertaining to adult studies indicates that low adiponectin levels are associated with increased CVD morbidity and mortality in the general population and patients with obesity and type 2 diabetes. In chronic kidney disease (CKD), however, despite an increased risk of poor cardiovascular outcomes, blood levels of adiponectin are actually higher than typical physiological levels. These unusual relationships question the protective role of elevated adiponectin in the milieu of CKD. This review summarizes the studies of adiponectin in the general pediatric population and its association with CVD risks in children and adults with CKD. Specific adiponectin values are generally avoided in this review, as there are no standardized normative values at this time – different assays with different “normal” cutoffs have been used and hence comparisons between studies would be invalid.

Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (2003) Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762–769PubMedCrossRef

Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941–946PubMedCrossRef

Wisse BE (2004) The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792–2800PubMedCrossRef

Yokota T, Meka CS, Kouro T, Medina KL, Igarashi H, Takahashi M, Oritani K, Funahashi T, Tomiyama Y, Matsuzawa Y, Kincade PW (2003) Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J Immunol 171:5091–5099PubMed

Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama Y, Matsuzawa Y (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723–1732PubMed

Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock ME (2004) Adiponectin differentially regulates cytokines in porcine macrophages. Biochem Biophys Res Commun 316:924–929PubMedCrossRef

Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y (2003) Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23:85–89PubMedCrossRef

Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102:1296–1301PubMed

Chinetti G, Zawadski C, Fruchart JC, Staels B (2004) Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR. Biochem Biophys Res Commun 314:151–158PubMedCrossRef

10.

Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y (2004) Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res (Online) 94:e27–e31

11.

Fisher FF, Trujillo ME, Hanif W, Barnett AH, McTernan PG, Scherer PE, Kumar S (2005) Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48:1084–1087PubMedCrossRef

12.

Bouskila M, Pajvani UB, Scherer PE (2005) Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity? Int J Obes (Lond) 29(Suppl 1):S17–S23CrossRef

13.

Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert MO, Möhlig M, Pfeiffer AF, Spranger J (2005) Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 54(9):2712–2719PubMedCrossRef

14.

Woo JG, Dolan LM, Daniels SR, Goodman E, Martin LJ (2005) Adolescent sex differences in adiponectin are conditional on pubertal development and adiposity. Obes Res 13:2095–2101PubMedCrossRef

15.

Ong KK, Frystyk J, Flyvbjerg A, Petry CJ, Ness A, Dunger DB (2006) Sex-discordant associations with adiponectin levels and lipid profiles in children. Diabetes 55:1337–1341PubMedCrossRef

16.

Martin LJ, Woo JG, Daniels SR, Goodman E, Dolan LM (2005) The relationships of adiponectin with insulin and lipids are strengthened with increasing adiposity. J Clin Endocrinol Metab 90:4255–4259PubMedCrossRef

17.

Lee S, Bacha F, Gungor N, Arslanian SA (2006) Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity. Diab Care 29:51–56CrossRef

18.

Böttner A, Kratzsch J, Müller G, Kapellen TM, Blüher S, Keller E, Blüher M, Kiess W (2004) Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 89:4053–4061PubMedCrossRef

19.

Bush NC, Darnell BE, Oster RA, Goran MI, Gower BA (2005) Adiponectin is lower among African Americans and is independently related to insulin sensitivity in children and adolescents. Diabetes 54:2772–2778PubMedCrossRef

20.

Guebre-Egziabher F, Bernhard J, Funahashi T, Hadj-Aissa A, Fouque D (2005) Adiponectin in chronic kidney disease is related more to metabolic disturbances than to decline in renal function. Nephrol Dial Transplant 20:129–134PubMedCrossRef

21.

Becker B, Kronenberg F, Kielstein JT, Haller H, Morath C, Ritz E, Fliser D (2005) Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. J Am Soc Nephrol 16:1091–1098PubMedCrossRef

22.

Zoccali C, Mallamaci F, Tripepi G, Benedetto FA, Cutrupi S, Parlongo S, Malatino LS, Bonanno G, Seminara G, Rapisarda F, Fatuzzo P, Buemi M, Nicocia G, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y (2002) Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 13:134–141PubMedCrossRef

23.

Stenvinkel P, Marchlewska A, Pecoits-Filho R, Heimbürger O, Zhang Z, Hoff C, Holmes C, Axelsson J, Arvidsson S, Schalling M, Barany P, Lindholm B, Nordfors L (2004) Adiponectin in renal disease: relationship to phenotype and genetic variation in the gene encoding adiponectin. Kidney Int 65:274–281PubMedCrossRef

24.

Bakkaloglu SA, Buyan N, Funahashi T, Pasaoglu H, Elhan AH, Hasanoglu E, Soylemezoglu O (2005) Adiponectin levels and atherosclerotic risk factors in pediatric chronic peritoneal dialysis patients. Perit Dial Int 25:357–361PubMed

25.

Díez JJ, Iglesias P, Fernández-Reyes MJ, Aguilera A, Bajo MA, Alvarez-Fidalgo P, Codoceo R, Selgas R (2005) Serum concentrations of leptin, adiponectin and resistin, and their relationship with cardiovascular disease in patients with end-stage renal disease. Clin Endocrinol (Oxf) 62:242–249CrossRef

26.

Chudek J, Adamczak M, Karkoszka H, Budziński G, Ignacy W, Funahashi T, Matsuzawa Y, Cierpka L, Kokot F, Wiecek A (2003) Plasma adiponectin concentration before and after successful kidney transplantation. Transplant Proc 35:2186–2189PubMedCrossRef

27.

Adamczak M, Szotowska M, Chudek J, Karkoszka H, Cierpka L, Wieçek A (2007) Plasma adiponectin concentration in patients after successful kidney transplantation–a single-center, observational study. Clin Nephrol 67:381–390PubMed

28.

Büscher AK, Büscher R, Hauffa BP, Hoyer PF (2010) Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease. Pediatr Nephrol 25:2295–2301PubMedCrossRef

29.

Halberg N, Schraw TD, Wang ZV, Kim JY, Yi J, Hamilton MP, Luby-Phelps K, Scherer PE (2009) Systemic fate of the adipocyte-derived factor adiponectin. Diabetes 58:1961–1970PubMedCrossRef

30.

Marchlewska A, Stenvinkel P, Lindholm B, Danielsson A, Pecoits-Filho R, Lönnqvist F, Schalling M, Heimbürger O, Nordfors L (2004) Reduced gene expression of adiponectin in fat tissue from patients with end-stage renal disease. Kidney Int 66(1):46–50PubMedCrossRef

31.

Mitsnefes MM, KJ KPR, Daniels SR (2007) Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. Clin J Am Soc Nephrol 2:46–50PubMedCrossRef

32.

Kollerits B, Fliser D, Heid IM, Reitz E, Kronenberg F (2007) Gender-specific association of adiponectin as a predictor of progression of chronic kidney disease: the mild to moderate kidney disease study. Kidney Int 71:1279–1286PubMedCrossRef

33.

Norata GD, Baragetti I, Raselli S, Stucchi A, Garlaschelli K, Vettoretti S, Piloni G, Buccianti G, Catapano AL (2010) Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status. Nutr Metab Cardiovasc Dis 20:56–63PubMedCrossRef

34.

Tamei N, Ogawa T, Ishida H, Ando Y, Nitta K (2010) Relationship of high-molecular-weight adiponectin levels to visceral fat accumulation in hemodialysis patients. Intern Med 49:299–305PubMedCrossRef

35.

Halleux CM, Takahashi M, Delporte ML, Detry R, Funahashi T, Matsuzawa Y, Brichard SM (2001) Biochem Biophys Res Commun 288:1102–1107PubMedCrossRef

36.

Axelsson J, Heimburger O, Lindholm B, Stenvinkel P (2005) Adipose tissue and its relation to inflammation: the role of adipokines. J Ren Nutr 15:131–136PubMedCrossRef

37.

Sethna CB, Leonard MB, Gallagher PR, Meyers KE (2009) Serum adiponectin levels and ambulatory blood pressure monitoring in pediatric renal transplant recipients. Transplantation 88:1030–1037PubMedCrossRef

38.

Bakkaloglu SA, Soylemezoglu O, Buyan N, Oktar SO, Funahashi T, Pasaoglu H, Elhan AH, Peru H, Hasanoglu E (2006) Adiponectin levels and arteriosclerotic risk factors in pediatric renal transplant recipients. Pediatr Transplant 10:187–192PubMedCrossRef

39.

Dunajska K, Milewicz A, Jedrzejuk D, Szymczak J, Kuliczkowski W, Salomon P, Bialy D, Poczatek K, Nowicki P (2004) Plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men. Endocr 25:215–221CrossRef

40.

Iwashima Y, Katsuya T, Ishikawa K, Ouchi N, Ohishi M, Sugimoto K, Fu Y, Motone M, Yamamoto K, Matsuo A, Ohashi K, Kihara S, Funahashi T, Rakugi H, Matsuzawa Y, Ogihara T (2004) Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43:1318–1323PubMedCrossRef

41.

Shioji K, Moriguchi A, Moriwaki S, Manabe K, Takeuchi Y, Uegaito T, Mutsuo S, Matsuda M (2005) Hypoadiponectinemia implies the development of atherosclerosis in carotid and coronary arteries. J Cardiol 46:105–112PubMed

42.

Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, Hokanson JE, Ehrlich J, Eckel RH, Rewers M (2005) Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 111:747–753PubMedCrossRef

43.

Menon V, Li L, Wang X, Greene T, Balakrishnan V, Madero M, Pereira AA, Beck GJ, Kusek JW, Collins AJ, Levey AS, Sarnak MJ (2006) Adiponectin and mortality in patients with chronic kidney disease. J Am Soc Nephrol 17:2599–2606PubMedCrossRef

44.

Park SH, Carrero JJ, Lindholm B, Stenvinkel P (2009) Adiponectin in chronic kidney disease has an opposite impact on protein-energy wasting and cardiovascular risk: two sides of the same coin. Clin Nephrol 72:87–96PubMed

45.

Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K (2004) Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279:1304–1309PubMedCrossRef

46.

Okamoto Y, Kihara S, Ouchi N, Nishida M, Arita Y, Kumada M, Ohashi K, Sakai N, Shimomura I, Kobayashi H, Terasaka N, Inaba T, Funahashi T, Matsuzawa Y (2002) Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice. Circulation 106:2767–2770PubMedCrossRef

47.

Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N, Kumada M, Okamoto Y, Nagaretani H, Nishizawa H, Kishida K, Komuro R, Ouchi N, Kihara S, Nagai R, Funahashi T, Matsuzawa Y (2002) Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 277:37487–37491PubMedCrossRef

48.

Pilz S, Horejsi R, Moller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H (2005) Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. J Clin Endocrinol Metab 90(8):4792–4796PubMedCrossRef

49.

Pilz S, Horejsi R, Möller R, Almer G, Scharnagl H, Stojakovic T, Dimitrova R, Weihrauch G, Borkenstein M, Maerz W, Schauenstein K, Mangge H (2004) Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index. Blood Press 13:236–242CrossRef

50.

Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR, Kumada M, Sato K, Schiekofer S, Ohashi K, Funahashi T, Colucci WS, Walsh K (2004) Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10:1384–1389PubMedCrossRef

51.

Piñeiro R, Iglesias MJ, Gallego R, Raghay K, Eiras S, Rubio J, Diéguez C, Gualillo O, González-Juanatey JR, Lago F (2005) Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett 579:5163–5169PubMedCrossRef

52.

Sharma K, RamachandraRao S, Qiu G, Kataoka Usui H, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 118:1645–1656PubMed

53.

Ohashi K, Iwatani H, Kihara S, Nakagawa Y, Komura N, Fujita K, Maeda N, Nishida M, Katsube F, Shimomura I, Ito T, Funahashi T (2007) Exacerbation of albuminuria and renal fibrosis in subtotal renal ablation model of adiponectin-knockout mice. Arterioscler Thromb Vasc Biol 27:1910–1917PubMedCrossRef

54.

Oguz Y, Yilmaz MI, Acikel C, Eyileten T, Caglar K, Oktenli C, Yenicesu M, Vural A (2009) The relationship between adiponectin levels and degree of proteinuria in patients with nephrotic and non-nephrotic proteinuria. Ren Fail 31:29–35PubMedCrossRef

55.

Hayakawa K, Ohashi H, Yokoyama H, Yoshida G, Okada M, Minatoguchi S (2009) Adiponectin is increased and correlated with the degree of proteinuria, but plasma leptin is not changed in patients with chronic glomerulonephritis. Nephrology (Carlton Print) 14:327–331CrossRef

56.

Teplan V Jr, Vyhnánek F, Gürlich R, Haluzík M, Racek J, Vyhnankova I, Stollová M, Teplan V (2010) Increased proinflammatory cytokine production in adipose tissue of obese patients with chronic kidney disease. Wien Klin Wochenschr 122:466–473PubMedCrossRef

57.

Zoccali C, Mallamaci F, Panuccio V, Tripepi G, Cutrupi S, Parlongo S, Catalano F, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y (2003) Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors. Kidney Int Suppl 84:S98–S102PubMedCrossRef

58.

Bakkaloglu SA, Soylemezoglu O, Buyan N, Funahashi T, Elhan AH, Peru H, Fidan K, Yilmaz S, Hasanoglu E (2005) High serum adiponectin levels during steroid-responsive nephrotic syndrome relapse. Pediatr Nephrol 20:474–477PubMedCrossRef

59.

Shen YY, Hughes JT, Charlesworth JA, Kelly JJ, Peake PW (2008) Adiponectin is present in the urine in its native conformation, and specifically reduces the secretion of MCP-1 by proximal tubular cells. Nephrology (Carlton Print) 13:405–410CrossRef

Titel: Adiponectin, cardiovascular disease, chronic kidney disease: emerging data on complex interactions
verfasst von: Megan M. Lo
Mark Mitsnefes
Publikationsdatum: 01.04.2012
Verlag: Springer-Verlag
Erschienen in: Pediatric Nephrology / Ausgabe 4/2012
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1804-2

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Adiponectin, cardiovascular disease, chronic kidney disease: emerging data on complex interactions

Abstract

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2012

Evidence that NPHS2-R229Q predisposes to proteinuria and renal failure in familial hematuria

Prevalence of lower urinary tract symptoms in school-age children

Renal involvement in mitochondrial cytopathies

Urinary N-acetyl-beta-D glucosaminidase (NAG) level in idiopathic nephrotic syndrome

Adenine phosphoribosyltransferase deficiency in children

Increased urinary calcium excretion caused by ceftriaxone: possible association with urolithiasis

Neu im Fachgebiet Pädiatrie

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Pädiatrie