Erschienen in:
01.09.2004 | Poster presentation
Advanced glycation endproducts in the development of osteoarthritis
verfasst von:
J DeGroot, RA Bank, JWJ Bijlsma, JM TeKoppele, N Verzijl, FPJG Lafeber
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
Osteoarthritis (OA) is one of the most prevalent and disabling chronic conditions affecting the elderly. The most prominent feature of OA is the progressive destruction of articular cartilage resulting in impaired joint motion, severe pain and, ultimately, disability. Age is identified as the main risk factor for the development of OA, but the mechanism by which aging is involved still remains largely unclear. Age-related changes in the articular cartilage could play an important role in the susceptibility of cartilage to OA. One of the major age-related changes in articular cartilage is the accumulation of advanced glycation endproducts (AGEs), resulting from the spontaneous reaction of reducing sugars with proteins. The present studies were designed to investigate whether AGE accumulation in cartilage may predispose to the development of OA. …