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Journal of Neural Transmission

Erschienen in:

01.09.2008 | Basic Neurosciences, Genetics and Immunology - Original Article

Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein

verfasst von: Anna Filipek, Gabriela Schneider, Anna Mietelska, Izabela Figiel, Grazyna Niewiadomska

Erschienen in: Journal of Neural Transmission | Ausgabe 9/2008

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Abstract

CacyBP/SIP was originally identified as an S100A6 (calcyclin) target and later on as a Siah-1 interacting protein. Recently, we have shown that CacyBP/SIP interacts with tubulin, which suggests its involvement in the reorganization of microtubules. In this work we examined the localization of CacyBP/SIP in cultured neurons and in brain neurons of young and aged rats, and compared this localization with that of tubulin and the tau protein. We have found that in neurons of young rats CacyBP/SIP, tubulin and tau are present in the cytoplasm and in the neuronal processes, whereas in aged animals CacyBP/SIP and tau are mainly seen in the cytoplasm of the neuronal somata. In aged rats, these changes are also accompanied by a different localization pattern of tubulin. Thus, our results show that localization of CacyBP/SIP in brain neurons is similar to that observed for tau and tubulin, which points to the involvement of CacyBP/SIP in cytoskeletal physiology.

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Titel: Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein
verfasst von: Anna Filipek
Gabriela Schneider
Anna Mietelska
Izabela Figiel
Grazyna Niewiadomska
Publikationsdatum: 01.09.2008
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 9/2008
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0062-3

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