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Acta Neuropathologica
Erschienen in: Acta Neuropathologica 2/2006

01.02.2006 | Original Paper

Age-related microvascular degeneration in the human cerebral periventricular white matter

verfasst von: Eszter Farkas, Rob A. I. de Vos, Gergely Donka, E. N. Jansen Steur, András Mihály, Paul G. M. Luiten

Erschienen in: Acta Neuropathologica | Ausgabe 2/2006

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Abstract

Clinical studies have identified white matter (WM) lesions as hyperintensive regions in the MRI images of elderly patients. Since a cerebrovascular origin was attributed to such lesions, the present analysis set out to define the microvascular histopathologic changes in the periventricular WM in the aged. Post-mortem samples of the frontal, parietal, and occipital periventricular WM of 40–90-year-old subjects were prepared for quantitative light and electron microscopy. Light microscopic examination revealed microvascular fibrohyalinosis as the most common type of microvascular damage in the elderly. Ultrastructural analysis identified the microvascular thickening as collagen deposits affecting the basement membrane. The vascular density did not correlate with the age. The basement membrane pathology significantly increased, while the number of intact microvessels gradually decreased, with advancing age in the frontal and occipital WM. Finally, peripheral atherosclerosis coincided with massive microvascular fibrosis, particularly in the frontal WM. Our results demonstrate an age-related microvascular degeneration in the periventricular WM, which may contribute to the development of WM lesions by hindering a sufficient supply of nutrients to the affected WM sites. Furthermore, the data accord with previous observations identifying the frontal lobe as the site at which WM vulnerability is most pronounced. Finally, atherosclerosis in large, peripheral vessels is considered to be a predictive marker of microvascular pathology in the WM.
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Metadaten
Titel
Age-related microvascular degeneration in the human cerebral periventricular white matter
verfasst von
Eszter Farkas
Rob A. I. de Vos
Gergely Donka
E. N. Jansen Steur
András Mihály
Paul G. M. Luiten
Publikationsdatum
01.02.2006
Verlag
Springer-Verlag
Erschienen in
Acta Neuropathologica / Ausgabe 2/2006
Print ISSN: 0001-6322
Elektronische ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-005-0007-y

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