Aggressive lymphoma involving intracranial epidural region

Excerpt

A 76-year old Mexican male was referred to our unit because of an ulcerated mass affecting scalp-skin over the occipital region, with a diameter of 8 × 6 cm. Physical examination showed an ulcerate mass with yellow secretion in the occipital region (Fig. 1A), and some protuberances in the frontal and left temporal region (Fig. 1B, black arrows). A biopsy of ulcerated mass reported to diffuse Large B-cell Lymphoma (Germinal Centre origin: CD10+, bcl-6+, MUM−1 negative). Cranial magnetic resonance image (MRI) showed epidural lesions in frontal and left temporal region as well as an epidural mass on occipital region that has destroyed the vault and affected subcutaneous and skin layers (Fig. 1C). Lumbar punction was negative to infiltrative disease. We started R-CHOP every 14 days at the same time as Intrathecal(IT) chemotherapy with 25 mg of Rituximab as prophylaxis. After 8 cycles of treatment, the ulcer lesion of the skin almost scared and the protuberances in the frontal and left temporal region (Fig. 2A and B) disappeared; MRI showed normal epidural region without any lesion (Fig. 2C). The patient has 13 months in complete remission after treatment and no relapse in Central Nervous System or meningeal compartment using as prophylaxis IT Rituximab.

…