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03.11.2016 | Review

Allergens and molecular diagnostics of shellfish allergy

Part 22 of the Series Molecular Allergology

verfasst von: Prof. Dr. Andreas L. Lopata, Jörg Kleine-Tebbe, Sandip D. Kamath

Erschienen in: Allergo Journal | Ausgabe 7/2016

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Abstract

Shellfish belongs to “The Big 8” food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca²⁺-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease.

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Titel: Allergens and molecular diagnostics of shellfish allergy
Part 22 of the Series Molecular Allergology
verfasst von: Prof. Dr. Andreas L. Lopata
Jörg Kleine-Tebbe
Sandip D. Kamath
Publikationsdatum: 03.11.2016
Verlag: Springer Medizin
Erschienen in: Allergo Journal / Ausgabe 7/2016
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI: https://doi.org/10.1007/s15007-016-1194-7

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Allergens and molecular diagnostics of shellfish allergy

Part 22 of the Series Molecular Allergology

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