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Journal of Neural Transmission

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06.02.2017 | Translational Neurosciences - Review Article

Alpha-synuclein and iron: two keys unlocking Parkinson’s disease

verfasst von: Paul Lingor, Eleonora Carboni, Jan Christoph Koch

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2017

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Abstract

Current therapies for Parkinson’s disease (PD) confer symptomatic relief and are particularly efficient in the treatment of motor symptoms in earlier disease stages. However, we are still unable to treat the causes of neurodegeneration by modification of the underlying mechanisms, which is partially due to their insufficient understanding. In this short review, we focus on two pivotal disease mechanisms: alpha-synuclein pathology and dysfunction of iron homeostasis as well as their intricate interaction. Both pathomechanisms have been extensively studied in the past and represent valid targets for disease-modifying pharmacological treatment approaches for PD. We summarize the current attempts to exploit iron chelation and modification of alpha-synuclein pathology as translational therapies in PD and discuss the chances and challenges of prospective disease-modifying approaches.

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Titel: Alpha-synuclein and iron: two keys unlocking Parkinson’s disease
verfasst von: Paul Lingor
Eleonora Carboni
Jan Christoph Koch
Publikationsdatum: 06.02.2017
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 8/2017
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-017-1695-x

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