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Comparative Clinical Pathology

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21.03.2019 | Original Article

Altered blood procalcitonin, C-reactive protein, and leucocytes count in association with canine parvovirus (CPV) enteritis

verfasst von: A. A. Kubesy, G. M. Rakha, Shaymaa I. Salem, A. H. Jaheen

Erschienen in: Comparative Clinical Pathology | Ausgabe 4/2019

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Abstract

Canine parvovirus enteritis is a highly contagious viral disease which causes high morbidity and mortality rates in young puppies. This study aimed to evaluate the diagnostic value of procalcitonin as an inflammatory biomarker as compared with C-reactive protein and total leucocyte count in canine parvovirus enteritis. This study was carried out on 41 dogs constituting 14 apparently healthy dogs used as a control and 27 dogs affected with canine parvovirus enteritis. Inflammatory biomarkers analysis showed a significant increase in C-reactive protein, a significant decrease in leucocytes counts, and an insignificant increase in procalcitonin level. Hematological profile showed a significant decrease in red blood cells count, hemoglobin content, packed cell volume %, mean corpuscular hemoglobin, and an insignificant increase in the mean corpuscular volume, and significant leucopenia, associated with neutropenia, lymphopenia, and monocytosis in addition to significant hypoproteinemia in canine parvovirus enteritis. Analysis of C-reactive protein concentration is found to be more effective than leucocytes count and procalcitonin concentration as an inflammatory biomarker in canine parvovirus enteritis.

Andrea L, Vinodkumar K, Tresamol PV, Justin DK, Priya PM (2017) Hematological changes in dogs with parvovirus enteritis in Thrissur district. IJIR 3(6):1323–1325

Arora R, Tyagi A, Shekhar S, Rajora VS, Arora N (2018) Haemato-biochemical alterations in gastroenteritis affected dogs. J Entomol Zool Stud 6(5):972–974

Bhat AA, Wadhwa DR, Khan MA (2013) Therapeutic management of canine parvoviral (CPV) gastroenteritis. Vet Pract 14(1):96–97

Dossin O, Rupassara S, Weng HY, Williams D, Garlick P, Schoeman JP (2011) Effect of parvoviral enteritis on plasma citrulline concentration in dogs. J Vet Intern Med 25:215–221CrossRefPubMed

Feldman BV, Zinkl JG, Jain NC, Schalm OW (2000) Schalm’s veterinary hematology, 5th edn. Lippincott Williams & Wilkins, Philadelphia

Goddard A, Leisewitz AL (2010) Canine parvovirus. Vet Clin North Am Small Anim Pract 40(6):1041–1053CrossRefPubMed

Goddard A, Leisewitz AL, Christopher M, Duncan N, Becker P (2008) Prognostic usefulness of blood leukocyte changes in canine parvoviral enteritis. J Vet Intern Med 22:309–316CrossRefPubMed

Goggs R, Milloway M, Troia R, Giunti M (2018) Plasma procalcitonin concentrations are increased in dogs with sepsis. Vet Rec Open 5:e000255CrossRefPubMedPubMedCentral

Gruys E, Toussaint MJ, Niewold TA, Koopmans SJ (2005) Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B(6):1045–1056CrossRef

Jensen AL, Kjelgaard-Hansen M (2006) Method comparison in the clinical laboratory. Vet Clin Pathol 35:276–286CrossRefPubMed

Kalli I, Leontides LS, Mylonakis ME, Adamama-Moraitou K, Rallis T, Koutinas AF (2010) Factors affecting the occurrence, duration of hospitalization and final outcome in canine parvovirus infection. Res Vet Sci 89(2):174–178CrossRef

Kaneko JJ, Harvey JW, Bruss ML (2008) Clinical biochemistry of domestic animals, 6th edn. Academic Press, New York, pp 881–888

Kocaturk M, Martinez S, Eralp O, Tvarijonaviciute A, Ceron J, Yilmaz Z (2010) Prognostic value of serum acute phase proteins in dogs with parvoviral enteritis. J Small Anim Pract 51:478–483CrossRefPubMed

Kocaturk M, Tvarijonaviciute A, Martinez-Subiela S, Tecles F, Eralp O, Yilmaz Z, Ceron JJ (2015) Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis. J Small Anim Pract 56(2):119–124CrossRefPubMed

Li R, Humm KR (2015) Canine parvovirus infection. In: Silverstein DC, Hoper K (eds) Small Animal Critical Care Medicine, 2nd edn. Elsevier, St Louis, pp 509–513CrossRef

Ling M, Norris JM, Kelman M, Ward MP (2012) Risk factors for death from canine parvoviral-related disease in Australia. Vet Microbiol 158:280–290CrossRefPubMed

Linscheid P, Seboek D, Nylen ES, Langer I, Schlatter M, Becker KL, Keller U, Müller B (2003) In vitro and in vivo calcitonin I gene expression in parenchymal cells: a novel product of human adipose tissue. J Endocrinol 144(12):5578–5584CrossRef

Mantione NL, Otto CM (2005) Characterization of the use of antiemetic agents in dogs with parvoviral enteritis treated at a veterinary teaching hospital: 77 cases (1997-2000). J Am Vet Med Assoc 227:1787–1793CrossRefPubMed

Marcovich JE, Stucker KM, Carr AH, Harbison CE, Scarlett JM, Parrish CR (2012) Effects of canine parvovirus strain variations on diagnostic test results and clinical management of enteritis in dogs. J Am Vet Med Assoc 241(1):66–72CrossRef

McCaw DL, Hoskins JD (2006) Canine viral enteritis. In: Green CE (ed) Infectious Diseases of the Dog and Cat, 4th edn. Saunders, St Louis, pp 63–73

McClure V, van Schoor M, Goddard A, Thompson P, Kjelgaard-Hansen M, Goddard A (2013) Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus. J Am Vet Med Assoc 243(3):361–366CrossRefPubMed

Melendi GA, Laham FR, Monsalvo C et al (2007) Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus or influenza virus in infants. J Pediatr 120:e410–e415CrossRef

Mohr AJ, Leisewitz AL, Jacobson LS, Steiner JM, Ruaux CG, Williams DA (2003) Effect of early enteral nutrition on intestinal permeability, intestinal protein loss, and outcome in dogs with severe parvoviral enteritis. J Vet Intern Med 17:791–798CrossRefPubMed

Müller CA, Uhl W, Printzen G, Gloor B, Bischofberger H, Tcholakov O, Büchler MW (2000) Role of procalcitonin and granulocyte colony-stimulating factor in the early prediction of infected necrosis in severe acute pancreatitis. Gut 46:233–238CrossRefPubMedPubMedCentral

Mylonakis ME, Kalli I, Rallis TS (2016) Canine parvoviral enteritis: an update on the clinical diagnosis, treatment, and prevention. VMRR 7:91–100CrossRef

Oruç N, Ozütemiz O, Osmanoğlu N, Ilter T (2009) Diagnostic value of serum procalcitonin in determining the activity of inflammatory bowel disease. Turk J Gastroenterol 20:9–12PubMed

Panda D, Patra R, Nandi S, Swarup D (2009) Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection. Res Vet Sci 86:36–42CrossRefPubMed

Pfister R, Kochanek M, Leygeber T, Brun-Buisson C, Cuquemelle E, Paiva Machado MB et al (2014) Procalcitonin for diagnosis of bacterial pneumonia in critically ill patients during 2009 H1N1 influenza pandemic: a prospective cohort study, systematic review and individual patient data meta-analysis. Crit Care 18:R44CrossRefPubMedPubMedCentral

Prittie J (2004) Canine parvoviral enteritis: a review of diagnosis, management, and prevention. J Vet Emerg Crit Care 14:167–176CrossRef

Schoeman JP, Goddard A, Leisewitz AL (2013) Biomarkers in canine parvovirus enteritis. N Z Vet J 61(4):217–222CrossRefPubMed

Schültzle H, Forster J, Superti-Furga A et al (2009) Is serum procalcitonin a reliable diagnostic marker in children with acute respiratory tract infections. Eur J Pediatr 168:1117–1124CrossRef

Sulthana CMJ (2015) Clinico-pathological findings in dogs affected with canine parvo virus (CPV) infections. Intas Polivet 16(II):443–444

Sykes JE (2014) Canine parvovirus infections and other viral enteritides. In: Sykes JE (ed) Canine and Feline Infectious Diseases, 1st edn. Elsevier, St Louis, pp 141–151CrossRef

Yilmaz Z, Senturk S (2007) Characterisation of lipid profiles in dogs with parvoviral enteritis. J Small Anim Pract 48:643–650CrossRefPubMed

Titel: Altered blood procalcitonin, C-reactive protein, and leucocytes count in association with canine parvovirus (CPV) enteritis
verfasst von: A. A. Kubesy
G. M. Rakha
Shaymaa I. Salem
A. H. Jaheen
Publikationsdatum: 21.03.2019
Verlag: Springer London
Erschienen in: Comparative Clinical Pathology / Ausgabe 4/2019
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-019-02941-y

Springer Medizin

Altered blood procalcitonin, C-reactive protein, and leucocytes count in association with canine parvovirus (CPV) enteritis

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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