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01.11.2010 | Original Article

An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line

verfasst von: Patricia Kohlhof

Erschienen in: Virchows Archiv | Ausgabe 5/2010

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Abstract

The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an increase in total intracellular NF-κB protein and mRNA levels as well as a temporary colocalization of NF-κB with proteasomes in human hepatocytes after treatment with TNF-α or IL-1β is reported. This indicates that beside an instantaneous activation of NF-κB and partly autoregulated inactivation by breakdown and synthesis of the inhibitors of NF-κB (IκBs), there are also mechanisms for a long-term regulation by de novo-synthesis and degradation of NF-κB protein.

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Titel: An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line
verfasst von: Patricia Kohlhof
Publikationsdatum: 01.11.2010
Verlag: Springer-Verlag
Erschienen in: Virchows Archiv / Ausgabe 5/2010
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0970-0

Springer Medizin

An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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