Why carry out this study?
|
Stratum corneum lipid replacement therapy is a promising strategy for treating dry skin conditions like atopic dermatitis. |
Dry skin is a common condition, affecting around 20% of children and 30–75% of adults over the age of 60. |
The aim was to provide evidence of the benefits of a cream and equivalent lotion containing skin lipids in a multi-vesicular emulsion for the management of dry skin. |
What was learned from the study?
|
In contrast to traditional emollients currently prescribed for dry skin, which require regular application 3–4 times per day, the test products imparted sustained moisturization lasting for more than 24 h. |
Reducing the number of applications required to keep the skin hydrated will help lessen the high burden of managing dry skin conditions. |
Introduction
Methods
Study Design
Name (brand name) | Manufacturer | Ingredients (active moisturizing agents) |
---|---|---|
Test cream, TC (CeraVe cream) | L’OREAL, Active Cosmetics Division | Aqua/water, glycerin, cetearyl alcohol, caprylic/capric triglyceride, cetyl alcohol, ceteareth-20, petrolatum, dimethicone, phenoxyethanol, behentrimonium methosulfate, potassium phosphate, ethylhexylglycerin, sodium lauroyl lactylate, disodium EDTA, dipotassium phosphate, ceramide NP, ceramide AP, phytosphingosine, cholesterol, xanthan gum, carbomer, sodium hyaluronate, tocopherol, ceramide EOP |
Test lotion, TL (CeraVe lotion) | L’OREAL, Active Cosmetics Division | Aqua/water, glycerin, caprylic/capric triglyceride, cetearyl alcohol, cetyl alcohol, dimethicone, phenoxyethanol, polysorbate 20, ceteareth-20, behentrimonium methosulfate, polyglyceryl-3 diisostearate, sodium lauroyl lactylate, ethylhexylglycerin, potassium phosphate, disodium EDTA, dipotassium phosphate, ceramide NP, ceramide AP, phytosphingosine, cholesterol, xanthan gum, carbomer, sodium hyaluronate, tocopherol, ceramide EOP |
Reference cream 1, RC1 (Zerobase cream) | Thornton & Ross Ltd | Purified water, liquid paraffin, white soft paraffin, cetostearyl alcohol, cetomacrogol, sodium dihydrogen phosphate, chlorocresol, phosphoric acid |
Reference cream 2, RC2 (Epimax cream) | Dermato-Logical | Purified water, white soft paraffin, liquid paraffin, polysorbate 60, cetosteryl alcohol, phenoxyethanol |
Reference cream 3, RC3 (Aquamax cream) | Intapharm Laboratories | Purified water, white soft paraffin, cetostearyl alcohol, liquid paraffin, polysorbate 60, phenoxyethanol |
Participants
Objective Measurement of SCH
Visual Scoring of Dryness
Statistical Analysis
Results
Demographic | Full analysis set (FAS) | Per protocol set (PPS) |
---|---|---|
n | 22 | 18 |
Age (mean) | 41 ± 2.96 | 43 ± 3.33 |
Sex | ||
Male | 10 | 7 |
Female | 12 | 11 |
Ethnicity | ||
White | 19 | 15 |
South Asian | 2 | 2 |
Mixed | 1 | 1 |
Fitzpatrick skin type (median) | 2 (range 1–5) | 3 (range 1–5) |
Atopic dermatitis (AD) | ||
Previously suffered from eczema but it is fully resolved | 5/22 (23%) | 5/18 (28%) |
Currently suffer from eczema but my skin is currently clear | 8/22 (36%) | 6/18 (33%) |
Currently suffer from eczema and it is currently active/visible | 9/22 (41%) | 7/18 (39%) |
SCH | 25.76 ± 1.81 | 23.31 ± 1.55 |
Dryness | 1.59 (range 0–3) | 1.83 (range 1–3) |