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Erschienen in: Journal of Anesthesia 1/2023

22.10.2022 | Review Article

Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone

verfasst von: Keisuke Yoshida, Shinju Obara, Satoki Inoue

Erschienen in: Journal of Anesthesia | Ausgabe 1/2023

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Abstract

At present, there is no objective and absolute measure of nociception, although various monitoring techniques have been developed. One such technique is the Analgesia Nociception Index (ANI), which is calculated from heart rate variability that reflects the relative parasympathetic tone. ANI is expressed on a non-unit scale of 0–100 (100 indicates maximal relative parasympathetic tone). Several studies indicated that ANI-guided anesthesia may help reduce intraoperative opioid use. The usefulness of ANI in the intensive care unit (ICU) and during surgery has also been reported. However, some limitations of ANI have also been reported; for example, ANI is affected by emotions and some drugs. In 2022, a high frequency variability index (HFVI), which was renamed from ANI and uses the same algorithm as ANI, was commercialized; therefore, ANI/HFVI are currently in the spotlight. Unlike ANI, HFVI can be displayed along with other biometric information on the Root® monitor. ANI/HFVI monitoring may affect the prognosis of not only patients in the perioperative period but those in ICU, those who receive home medical care, or outpatients. In this article, we present an updated review on ANI that has been published in the last decade, introduce HFVI, and discuss the outlooks of ANI/HFVI.
Literatur
1.
Zurück zum Zitat Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ, Mogil JS, Ringkamp M, Sluka KA, Song XJ, Stevens B, Sullivan MD, Tutelman PR, Ushida T, Vader K. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161:1976–82.PubMedPubMedCentral Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, Keefe FJ, Mogil JS, Ringkamp M, Sluka KA, Song XJ, Stevens B, Sullivan MD, Tutelman PR, Ushida T, Vader K. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161:1976–82.PubMedPubMedCentral
2.
Zurück zum Zitat Ledowski T. Objective monitoring of nociception: a review of current commercial solutions. Br J Anaesth. 2019;123:e312–21.PubMedPubMedCentral Ledowski T. Objective monitoring of nociception: a review of current commercial solutions. Br J Anaesth. 2019;123:e312–21.PubMedPubMedCentral
3.
Zurück zum Zitat von Dincklage F, Ledowski T. Monitoring of nociception: is more always more? Br J Anaesth. 2021;126:352–4. von Dincklage F, Ledowski T. Monitoring of nociception: is more always more? Br J Anaesth. 2021;126:352–4.
4.
Zurück zum Zitat Crellin DJ, Harrison D, Santamaria N, Huque H, Babl FE. The psychometric properties of the FLACC scale used to assess procedural pain. J Pain. 2018;19:862–72.PubMed Crellin DJ, Harrison D, Santamaria N, Huque H, Babl FE. The psychometric properties of the FLACC scale used to assess procedural pain. J Pain. 2018;19:862–72.PubMed
5.
Zurück zum Zitat Sabourdin N, Constant I. Monitoring of analgesia level during general anesthesia in children. Curr Opin Anaesthesiol. 2022;35:367–73.PubMed Sabourdin N, Constant I. Monitoring of analgesia level during general anesthesia in children. Curr Opin Anaesthesiol. 2022;35:367–73.PubMed
6.
Zurück zum Zitat Ledowski T, Pascoe E, Ang B, Schmarbeck T, Clarke MW, Fuller C, Kapoor V. Monitoring of intra-operative nociception: skin conductance and surgical stress index versus stress hormone plasma levels. Anaesthesia. 2010;65:1001–6.PubMed Ledowski T, Pascoe E, Ang B, Schmarbeck T, Clarke MW, Fuller C, Kapoor V. Monitoring of intra-operative nociception: skin conductance and surgical stress index versus stress hormone plasma levels. Anaesthesia. 2010;65:1001–6.PubMed
7.
Zurück zum Zitat Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. Prediction of opioid analgesic efficacy by measurement of pupillary unrest. Anesth Analg. 2017;124:915–21.PubMed Neice AE, Behrends M, Bokoch MP, Seligman KM, Conrad NM, Larson MD. Prediction of opioid analgesic efficacy by measurement of pupillary unrest. Anesth Analg. 2017;124:915–21.PubMed
8.
Zurück zum Zitat Ledowski T, Burke J, Hruby J. Surgical pleth index: prediction of postoperative pain and influence of arousal. Br J Anaesth. 2016;117:371–4.PubMed Ledowski T, Burke J, Hruby J. Surgical pleth index: prediction of postoperative pain and influence of arousal. Br J Anaesth. 2016;117:371–4.PubMed
9.
Zurück zum Zitat Martini CH, Boon M, Broens SJ, Hekkelman EF, Oudhoff LA, Buddeke AW, Dahan A. Ability of the nociception level, a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia. Anesthesiology. 2015;123:524–34.PubMed Martini CH, Boon M, Broens SJ, Hekkelman EF, Oudhoff LA, Buddeke AW, Dahan A. Ability of the nociception level, a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia. Anesthesiology. 2015;123:524–34.PubMed
10.
Zurück zum Zitat Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137:473–7.PubMed Loeser JD, Treede RD. The Kyoto protocol of IASP basic pain terminology. Pain. 2008;137:473–7.PubMed
11.
Zurück zum Zitat Sayers BM. Analysis of heart rate variability. Ergonomics. 1973;16:17–32.PubMed Sayers BM. Analysis of heart rate variability. Ergonomics. 1973;16:17–32.PubMed
12.
Zurück zum Zitat Jeanne M, Logier R, De Jonckheere J, Tavernier B. Validation of a graphic measurement of heart rate variability to assess analgesia/nociception balance during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1840–3.PubMed Jeanne M, Logier R, De Jonckheere J, Tavernier B. Validation of a graphic measurement of heart rate variability to assess analgesia/nociception balance during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1840–3.PubMed
13.
Zurück zum Zitat Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043–65. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043–65.
14.
Zurück zum Zitat Jeanne M, Clément C, De Jonckheere J, Logier R, Tavernier B. Variations of the analgesia nociception index during general anaesthesia for laparoscopic abdominal surgery. J Clin Monit Comput. 2012;26:289–94.PubMed Jeanne M, Clément C, De Jonckheere J, Logier R, Tavernier B. Variations of the analgesia nociception index during general anaesthesia for laparoscopic abdominal surgery. J Clin Monit Comput. 2012;26:289–94.PubMed
15.
Zurück zum Zitat Daccache G, Jeanne M, Fletcher D. The analgesia nociception index: tailoring opioid administration. Anesth Analg. 2017;125:15–7.PubMed Daccache G, Jeanne M, Fletcher D. The analgesia nociception index: tailoring opioid administration. Anesth Analg. 2017;125:15–7.PubMed
16.
Zurück zum Zitat Abdullayev R, Yildirim E, Celik B, Topcu SL. Analgesia nociception index: heart rate variability analysis of emotional status. Cureus. 2019;11: e4365.PubMedPubMedCentral Abdullayev R, Yildirim E, Celik B, Topcu SL. Analgesia nociception index: heart rate variability analysis of emotional status. Cureus. 2019;11: e4365.PubMedPubMedCentral
17.
Zurück zum Zitat De Jonckheere J, Rommel D, Nandrino JL, Jeanne M, Logier R. Heart rate variability analysis as an index of emotion regulation processes: interest of the analgesia nociception index (ANI). Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:3432–5.PubMed De Jonckheere J, Rommel D, Nandrino JL, Jeanne M, Logier R. Heart rate variability analysis as an index of emotion regulation processes: interest of the analgesia nociception index (ANI). Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:3432–5.PubMed
18.
Zurück zum Zitat Ledowski T, Tiong WS, Lee C, Wong B, Fiori T, Parker N. Analgesia nociception index: evaluation as a new parameter for acute postoperative pain. Br J Anaesth. 2013;111:627–9.PubMed Ledowski T, Tiong WS, Lee C, Wong B, Fiori T, Parker N. Analgesia nociception index: evaluation as a new parameter for acute postoperative pain. Br J Anaesth. 2013;111:627–9.PubMed
19.
Zurück zum Zitat Boselli E, Daniela-Ionescu M, Bégou G, Bouvet L, Dabouz R, Magnin C, Allaouchiche B. Prospective observational study of the non-invasive assessment of immediate postoperative pain using the analgesia/nociception index (ANI). Br J Anaesth. 2013;111:453–9.PubMed Boselli E, Daniela-Ionescu M, Bégou G, Bouvet L, Dabouz R, Magnin C, Allaouchiche B. Prospective observational study of the non-invasive assessment of immediate postoperative pain using the analgesia/nociception index (ANI). Br J Anaesth. 2013;111:453–9.PubMed
20.
Zurück zum Zitat Boselli E, Bouvet L, Bégou G, Dabouz R, Davidson J, Deloste JY, Rahali N, Zadam A, Allaouchiche B. Prediction of immediate postoperative pain using the analgesia/nociception index: a prospective observational study. Br J Anaesth. 2014;112:715–21.PubMed Boselli E, Bouvet L, Bégou G, Dabouz R, Davidson J, Deloste JY, Rahali N, Zadam A, Allaouchiche B. Prediction of immediate postoperative pain using the analgesia/nociception index: a prospective observational study. Br J Anaesth. 2014;112:715–21.PubMed
21.
Zurück zum Zitat Choi BM, Shin H, Lee JH, Bang JY, Lee EK, Noh GJ. Performance of the surgical pleth index and analgesia nociception index in healthy volunteers and parturients. Front Physiol. 2021;12: 554026.PubMedPubMedCentral Choi BM, Shin H, Lee JH, Bang JY, Lee EK, Noh GJ. Performance of the surgical pleth index and analgesia nociception index in healthy volunteers and parturients. Front Physiol. 2021;12: 554026.PubMedPubMedCentral
22.
Zurück zum Zitat Dostalova V, Schreiberova J, Bartos M, Kukralova L, Dostal P. Surgical pleth index and analgesia nociception index for intraoperative analgesia in patients undergoing neurosurgical spinal procedures: a comparative randomized study. Minerva Anestesiol. 2019;85:1265–72.PubMed Dostalova V, Schreiberova J, Bartos M, Kukralova L, Dostal P. Surgical pleth index and analgesia nociception index for intraoperative analgesia in patients undergoing neurosurgical spinal procedures: a comparative randomized study. Minerva Anestesiol. 2019;85:1265–72.PubMed
23.
Zurück zum Zitat Gruenewald M, Herz J, Schoenherr T, Thee C, Steinfath M, Bein B. Measurement of the nociceptive balance by analgesia nociception index and surgical pleth index during sevoflurane-remifentanil anesthesia. Minerva Anestesiol. 2015;81:480–9.PubMed Gruenewald M, Herz J, Schoenherr T, Thee C, Steinfath M, Bein B. Measurement of the nociceptive balance by analgesia nociception index and surgical pleth index during sevoflurane-remifentanil anesthesia. Minerva Anestesiol. 2015;81:480–9.PubMed
24.
Zurück zum Zitat Gruenewald M, Ilies C, Herz J, Schoenherr T, Fudickar A, Höcker J, Bein B. Influence of nociceptive stimulation on analgesia nociception index (ANI) during propofol-remifentanil anaesthesia. Br J Anaesth. 2013;110:1024–30.PubMed Gruenewald M, Ilies C, Herz J, Schoenherr T, Fudickar A, Höcker J, Bein B. Influence of nociceptive stimulation on analgesia nociception index (ANI) during propofol-remifentanil anaesthesia. Br J Anaesth. 2013;110:1024–30.PubMed
25.
Zurück zum Zitat Charier D, Vogler MC, Zantour D, Pichot V, Martins-Baltar A, Courbon M, Roche F, Vassal F, Molliex S. Assessing pain in the postoperative period: analgesia nociception index™ versus pupillometry. Br J Anaesth. 2019;123:e322–7.PubMedPubMedCentral Charier D, Vogler MC, Zantour D, Pichot V, Martins-Baltar A, Courbon M, Roche F, Vassal F, Molliex S. Assessing pain in the postoperative period: analgesia nociception index™ versus pupillometry. Br J Anaesth. 2019;123:e322–7.PubMedPubMedCentral
26.
Zurück zum Zitat Struys MM, Vanpeteghem C, Huiku M, Uutela K, Blyaert NB, Mortier EP. Changes in a surgical stress index in response to standardized pain stimuli during propofol-remifentanil infusion. Br J Anaesth. 2007;99:359–67.PubMed Struys MM, Vanpeteghem C, Huiku M, Uutela K, Blyaert NB, Mortier EP. Changes in a surgical stress index in response to standardized pain stimuli during propofol-remifentanil infusion. Br J Anaesth. 2007;99:359–67.PubMed
27.
Zurück zum Zitat Julien-Marsollier F, Rachdi K, Caballero MJ, Ayanmanesh F, Vacher T, Horlin AL, Skhiri A, Brasher C, Michelet D, Dahmani S. Evaluation of the analgesia nociception index for monitoring intraoperative analgesia in children. Br J Anaesth. 2018;121:462–8.PubMed Julien-Marsollier F, Rachdi K, Caballero MJ, Ayanmanesh F, Vacher T, Horlin AL, Skhiri A, Brasher C, Michelet D, Dahmani S. Evaluation of the analgesia nociception index for monitoring intraoperative analgesia in children. Br J Anaesth. 2018;121:462–8.PubMed
28.
Zurück zum Zitat Avez-Couturier J, De Jonckheere J, Jeanne M, Vallée L, Cuisset JM, Logier R. Assessment of procedural pain in children using analgesia nociception index: a pilot study. Clin J Pain. 2016;32:1100–4.PubMed Avez-Couturier J, De Jonckheere J, Jeanne M, Vallée L, Cuisset JM, Logier R. Assessment of procedural pain in children using analgesia nociception index: a pilot study. Clin J Pain. 2016;32:1100–4.PubMed
29.
Zurück zum Zitat Gall O, Champigneulle B, Schweitzer B, Deram T, Maupain O, Montmayeur Verchere J, Orliaguet G. Postoperative pain assessment in children: a pilot study of the usefulness of the analgesia nociception index. Br J Anaesth. 2015;115:890–5.PubMed Gall O, Champigneulle B, Schweitzer B, Deram T, Maupain O, Montmayeur Verchere J, Orliaguet G. Postoperative pain assessment in children: a pilot study of the usefulness of the analgesia nociception index. Br J Anaesth. 2015;115:890–5.PubMed
30.
Zurück zum Zitat Chanques G, Tarri T, Ride A, Prades A, De Jong A, Carr J, Molinari N, Jaber S. Analgesia nociception index for the assessment of pain in critically ill patients: a diagnostic accuracy study. Br J Anaesth. 2017;119:812–20.PubMed Chanques G, Tarri T, Ride A, Prades A, De Jong A, Carr J, Molinari N, Jaber S. Analgesia nociception index for the assessment of pain in critically ill patients: a diagnostic accuracy study. Br J Anaesth. 2017;119:812–20.PubMed
31.
Zurück zum Zitat Jendoubi A, Abbes A, Ghedira S, Houissa M. Pain measurement in mechanically ventilated patients with traumatic brain injury: behavioral pain tools versus analgesia nociception index. Indian J Crit Care Med. 2017;21:585–8.PubMedPubMedCentral Jendoubi A, Abbes A, Ghedira S, Houissa M. Pain measurement in mechanically ventilated patients with traumatic brain injury: behavioral pain tools versus analgesia nociception index. Indian J Crit Care Med. 2017;21:585–8.PubMedPubMedCentral
32.
Zurück zum Zitat Shanthanna H, Ladha KS, Kehlet H, Joshi GP. Perioperative opioid administration. Anesthesiology. 2021;134:645–59.PubMed Shanthanna H, Ladha KS, Kehlet H, Joshi GP. Perioperative opioid administration. Anesthesiology. 2021;134:645–59.PubMed
33.
Zurück zum Zitat Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46:e825–73.PubMed Devlin JW, Skrobik Y, Gélinas C, Needham DM, Slooter AJC, Pandharipande PP, Watson PL, Weinhouse GL, Nunnally ME, Rochwerg B, Balas MC, van den Boogaard M, Bosma KJ, Brummel NE, Chanques G, Denehy L, Drouot X, Fraser GL, Harris JE, Joffe AM, Kho ME, Kress JP, Lanphere JA, McKinley S, Neufeld KJ, Pisani MA, Payen JF, Pun BT, Puntillo KA, Riker RR, Robinson BRH, Shehabi Y, Szumita PM, Winkelman C, Centofanti JE, Price C, Nikayin S, Misak CJ, Flood PD, Kiedrowski K, Alhazzani W. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018;46:e825–73.PubMed
34.
Zurück zum Zitat Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017;152:292–8.PubMed Ljungqvist O, Scott M, Fearon KC. Enhanced recovery after surgery: a review. JAMA Surg. 2017;152:292–8.PubMed
35.
Zurück zum Zitat Theerth KA, Sriganesh K, Reddy KM, Chakrabarti D, Umamaheswara Rao GS. Analgesia nociception index-guided intraoperative fentanyl consumption and postoperative analgesia in patients receiving scalp block versus incision-site infiltration for craniotomy. Minerva Anestesiol. 2018;84:1361–8.PubMed Theerth KA, Sriganesh K, Reddy KM, Chakrabarti D, Umamaheswara Rao GS. Analgesia nociception index-guided intraoperative fentanyl consumption and postoperative analgesia in patients receiving scalp block versus incision-site infiltration for craniotomy. Minerva Anestesiol. 2018;84:1361–8.PubMed
36.
Zurück zum Zitat Soral M, Altun GT, Dinçer PÇ, Arslantaş MK, Aykaç Z. Effectiveness of the analgesia nociception index monitoring in patients who undergo colonoscopy with sedo-analgesia. Turk J Anaesthesiol Reanim. 2020;48:50–7.PubMed Soral M, Altun GT, Dinçer PÇ, Arslantaş MK, Aykaç Z. Effectiveness of the analgesia nociception index monitoring in patients who undergo colonoscopy with sedo-analgesia. Turk J Anaesthesiol Reanim. 2020;48:50–7.PubMed
37.
Zurück zum Zitat Sabourdin N, Burey J, Tuffet S, Thomin A, Rousseau A, Al-Hawari M, Taconet C, Louvet N, Constant I. Analgesia nociception index-guided remifentanil versus standard care during propofol anesthesia: a randomized controlled trial. J Clin Med. 2022;11:333.PubMedPubMedCentral Sabourdin N, Burey J, Tuffet S, Thomin A, Rousseau A, Al-Hawari M, Taconet C, Louvet N, Constant I. Analgesia nociception index-guided remifentanil versus standard care during propofol anesthesia: a randomized controlled trial. J Clin Med. 2022;11:333.PubMedPubMedCentral
38.
Zurück zum Zitat Dundar N, Kus A, Gurkan Y, Toker K, Solak M. Analgesia nociception index (ani) monitoring in patients with thoracic paravertebral block: a randomized controlled study. J Clin Monit Comput. 2018;32:481–6.PubMed Dundar N, Kus A, Gurkan Y, Toker K, Solak M. Analgesia nociception index (ani) monitoring in patients with thoracic paravertebral block: a randomized controlled study. J Clin Monit Comput. 2018;32:481–6.PubMed
39.
Zurück zum Zitat Le Gall L, David A, Carles P, Leuillet S, Chastel B, Fleureau C, Dewitte A, Ouattara A. Benefits of intraoperative analgesia guided by the analgesia nociception index (ANI) in bariatric surgery: an unmatched case-control study. Anaesth Crit Care Pain Med. 2019;38:35–9.PubMed Le Gall L, David A, Carles P, Leuillet S, Chastel B, Fleureau C, Dewitte A, Ouattara A. Benefits of intraoperative analgesia guided by the analgesia nociception index (ANI) in bariatric surgery: an unmatched case-control study. Anaesth Crit Care Pain Med. 2019;38:35–9.PubMed
40.
Zurück zum Zitat Upton HD, Ludbrook GL, Wing A, Sleigh JW. Intraoperative “analgesia nociception index”-guided fentanyl administration during sevoflurane anesthesia in lumbar discectomy and laminectomy: a randomized clinical trial. Anesth Analg. 2017;125:81–90.PubMed Upton HD, Ludbrook GL, Wing A, Sleigh JW. Intraoperative “analgesia nociception index”-guided fentanyl administration during sevoflurane anesthesia in lumbar discectomy and laminectomy: a randomized clinical trial. Anesth Analg. 2017;125:81–90.PubMed
41.
Zurück zum Zitat Tribuddharat S, Sathitkarnmanee T, Sukhong P, Thananun M, Promkhote P, Nonlhaopol D. Comparative study of analgesia nociception index (ANI) vs standard pharmacokinetic pattern for guiding intraoperative fentanyl administration among mastectomy patients. BMC Anesthesiol. 2021;21:50.PubMedPubMedCentral Tribuddharat S, Sathitkarnmanee T, Sukhong P, Thananun M, Promkhote P, Nonlhaopol D. Comparative study of analgesia nociception index (ANI) vs standard pharmacokinetic pattern for guiding intraoperative fentanyl administration among mastectomy patients. BMC Anesthesiol. 2021;21:50.PubMedPubMedCentral
42.
Zurück zum Zitat Szental JA, Webb A, Weeraratne C, Campbell A, Sivakumar H, Leong S. Postoperative pain after laparoscopic cholecystectomy is not reduced by intraoperative analgesia guided by analgesia nociception index (ANI®) monitoring: a randomized clinical trial. Br J Anaesth. 2015;114:640–5.PubMed Szental JA, Webb A, Weeraratne C, Campbell A, Sivakumar H, Leong S. Postoperative pain after laparoscopic cholecystectomy is not reduced by intraoperative analgesia guided by analgesia nociception index (ANI®) monitoring: a randomized clinical trial. Br J Anaesth. 2015;114:640–5.PubMed
43.
Zurück zum Zitat Jiao Y, He B, Tong X, Xia R, Zhang C, Shi X. Intraoperative monitoring of nociception for opioid administration: a meta-analysis of randomized controlled trials. Minerva Anestesiol. 2019;85:522–30.PubMed Jiao Y, He B, Tong X, Xia R, Zhang C, Shi X. Intraoperative monitoring of nociception for opioid administration: a meta-analysis of randomized controlled trials. Minerva Anestesiol. 2019;85:522–30.PubMed
44.
Zurück zum Zitat Boselli E, Jeanne M. Analgesia/nociception index for the assessment of acute postoperative pain. Br J Anaesth. 2014;112:936–7.PubMed Boselli E, Jeanne M. Analgesia/nociception index for the assessment of acute postoperative pain. Br J Anaesth. 2014;112:936–7.PubMed
45.
Zurück zum Zitat Jendoubi A, Khalloufi A, Nasri O, Abbes A, Ghedira S, Houissa M. Analgesia nociception index as a tool to predict hypotension after spinal anaesthesia for elective caesarean section. J Obstet Gynaecol. 2021;41:193–9.PubMed Jendoubi A, Khalloufi A, Nasri O, Abbes A, Ghedira S, Houissa M. Analgesia nociception index as a tool to predict hypotension after spinal anaesthesia for elective caesarean section. J Obstet Gynaecol. 2021;41:193–9.PubMed
46.
Zurück zum Zitat Ledowski T, Averhoff L, Tiong WS, Lee C. Analgesia nociception index (ANI) to predict intraoperative haemodynamic changes: results of a pilot investigation. Acta Anaesthesiol Scand. 2014;58:74–9.PubMed Ledowski T, Averhoff L, Tiong WS, Lee C. Analgesia nociception index (ANI) to predict intraoperative haemodynamic changes: results of a pilot investigation. Acta Anaesthesiol Scand. 2014;58:74–9.PubMed
47.
Zurück zum Zitat Boselli E, Logier R, Bouvet L, Allaouchiche B. Prediction of hemodynamic reactivity using dynamic variations of analgesia/nociception index (∆ANI). J Clin Monit Comput. 2016;30:977–84.PubMed Boselli E, Logier R, Bouvet L, Allaouchiche B. Prediction of hemodynamic reactivity using dynamic variations of analgesia/nociception index (∆ANI). J Clin Monit Comput. 2016;30:977–84.PubMed
48.
Zurück zum Zitat Jeanne M, Delecroix M, De Jonckheere J, Keribedj A, Logier R, Tavernier B. Variations of the analgesia nociception index during propofol anesthesia for total knee replacement. Clin J Pain. 2014;30:1084–8.PubMed Jeanne M, Delecroix M, De Jonckheere J, Keribedj A, Logier R, Tavernier B. Variations of the analgesia nociception index during propofol anesthesia for total knee replacement. Clin J Pain. 2014;30:1084–8.PubMed
49.
Zurück zum Zitat Boselli E, Bouvet L, Bégou G, Torkmani S, Allaouchiche B. Prediction of hemodynamic reactivity during total intravenous anesthesia for suspension laryngoscopy using analgesia/nociception index (ANI): a prospective observational study. Minerva Anestesiol. 2015;81:288–97.PubMed Boselli E, Bouvet L, Bégou G, Torkmani S, Allaouchiche B. Prediction of hemodynamic reactivity during total intravenous anesthesia for suspension laryngoscopy using analgesia/nociception index (ANI): a prospective observational study. Minerva Anestesiol. 2015;81:288–97.PubMed
50.
Zurück zum Zitat Sabourdin N, Arnaout M, Louvet N, Guye ML, Piana F, Constant I. Pain monitoring in anesthetized children: first assessment of skin conductance and analgesia-nociception index at different infusion rates of remifentanil. Paediatr Anaesth. 2013;23:149–55.PubMed Sabourdin N, Arnaout M, Louvet N, Guye ML, Piana F, Constant I. Pain monitoring in anesthetized children: first assessment of skin conductance and analgesia-nociception index at different infusion rates of remifentanil. Paediatr Anaesth. 2013;23:149–55.PubMed
51.
Zurück zum Zitat Weber F, Geerts NJE, Roeleveld HG, Warmenhoven AT, Liebrand CA. The predictive value of the heart rate variability-derived analgesia nociception index in children anaesthetized with sevoflurane: an observational pilot study. Eur J Pain. 2018;22:1597–605.PubMedPubMedCentral Weber F, Geerts NJE, Roeleveld HG, Warmenhoven AT, Liebrand CA. The predictive value of the heart rate variability-derived analgesia nociception index in children anaesthetized with sevoflurane: an observational pilot study. Eur J Pain. 2018;22:1597–605.PubMedPubMedCentral
52.
Zurück zum Zitat De Jonckheere J, Delecroix M, Jeanne M, Keribedj A, Couturier N, Logier R. Automated analgesic drugs delivery guided by vagal tone evaluation: interest of the analgesia nociception index (ANI). Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:1952–5.PubMed De Jonckheere J, Delecroix M, Jeanne M, Keribedj A, Couturier N, Logier R. Automated analgesic drugs delivery guided by vagal tone evaluation: interest of the analgesia nociception index (ANI). Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:1952–5.PubMed
53.
Zurück zum Zitat Xie H, Chen W, Liu J, Li J, Li S. Changes of analgesia/nociception index under different surgical steps in abortion under general anesthesia: a prospective clinical study. J Clin Anesth. 2020;66: 109898.PubMed Xie H, Chen W, Liu J, Li J, Li S. Changes of analgesia/nociception index under different surgical steps in abortion under general anesthesia: a prospective clinical study. J Clin Anesth. 2020;66: 109898.PubMed
54.
Zurück zum Zitat Le Guen M, Jeanne M, Sievert K, Al Moubarik M, Chazot T, Laloë PA, Dreyfus JF, Fischler M. The analgesia nociception index: a pilot study to evaluation of a new pain parameter during labor. Int J Obstet Anesth. 2012;21:146–51.PubMed Le Guen M, Jeanne M, Sievert K, Al Moubarik M, Chazot T, Laloë PA, Dreyfus JF, Fischler M. The analgesia nociception index: a pilot study to evaluation of a new pain parameter during labor. Int J Obstet Anesth. 2012;21:146–51.PubMed
55.
Zurück zum Zitat Migeon A, Desgranges FP, Chassard D, Blaise BJ, De Queiroz M, Stewart A, Cejka JC, Combet S, Rhondali O. Pupillary reflex dilatation and analgesia nociception index monitoring to assess the effectiveness of regional anesthesia in children anesthetised with sevoflurane. Paediatr Anaesth. 2013;23:1160–5.PubMed Migeon A, Desgranges FP, Chassard D, Blaise BJ, De Queiroz M, Stewart A, Cejka JC, Combet S, Rhondali O. Pupillary reflex dilatation and analgesia nociception index monitoring to assess the effectiveness of regional anesthesia in children anesthetised with sevoflurane. Paediatr Anaesth. 2013;23:1160–5.PubMed
56.
Zurück zum Zitat Lee JH, Choi BM, Jung YR, Lee YH, Bang JY, Noh GJ. Evaluation of surgical pleth index and analgesia nociception index as surrogate pain measures in conscious postoperative patients: an observational study. J Clin Monit Comput. 2020;34:1087–93.PubMed Lee JH, Choi BM, Jung YR, Lee YH, Bang JY, Noh GJ. Evaluation of surgical pleth index and analgesia nociception index as surrogate pain measures in conscious postoperative patients: an observational study. J Clin Monit Comput. 2020;34:1087–93.PubMed
57.
Zurück zum Zitat Issa R, Julien M, Décary E, Verdonck O, Fortier LP, Drolet P, Richebé P. Evaluation of the analgesia nociception index (ANI) in healthy awake volunteers. Can J Anaesth. 2017;64:828–35.PubMed Issa R, Julien M, Décary E, Verdonck O, Fortier LP, Drolet P, Richebé P. Evaluation of the analgesia nociception index (ANI) in healthy awake volunteers. Can J Anaesth. 2017;64:828–35.PubMed
58.
Zurück zum Zitat Baroni DA, Abreu LG, Paiva SM, Costa LR. Comparison between analgesia nociception index (ANI) and self-reported measures for diagnosing pain in conscious individuals: a systematic review and meta-analysis. Sci Rep. 2022;12:2862.PubMedPubMedCentral Baroni DA, Abreu LG, Paiva SM, Costa LR. Comparison between analgesia nociception index (ANI) and self-reported measures for diagnosing pain in conscious individuals: a systematic review and meta-analysis. Sci Rep. 2022;12:2862.PubMedPubMedCentral
59.
Zurück zum Zitat Jess G, Pogatzki-Zahn EM, Zahn PK, Meyer-Frießem CH. Monitoring heart rate variability to assess experimentally induced pain using the analgesia nociception index: A randomised volunteer study. Eur J Anaesthesiol. 2016;33:118–25.PubMed Jess G, Pogatzki-Zahn EM, Zahn PK, Meyer-Frießem CH. Monitoring heart rate variability to assess experimentally induced pain using the analgesia nociception index: A randomised volunteer study. Eur J Anaesthesiol. 2016;33:118–25.PubMed
60.
Zurück zum Zitat Graça R, Lobo FA. Analgesia nociception index (ANI) and ephedrine: a dangerous liasion. J Clin Monit Comput. 2021;35:953–4.PubMed Graça R, Lobo FA. Analgesia nociception index (ANI) and ephedrine: a dangerous liasion. J Clin Monit Comput. 2021;35:953–4.PubMed
61.
Zurück zum Zitat Boselli E, Jacquet-Lagrèze M, Ayoub JY, Bouvet L, Dauwalder O, Mansour C, Margez T, Paquet C, Restagno D, Allaouchiche B, Bonnet-Garin JM, Junot S. Effects of esmolol on systemic hemodynamics and heart rate variability measured using the analgesia/nociception index in resuscitated piglets with Pseudomonas aeruginosa septic shock. J Vet Emerg Crit Care (San Antonio). 2018;28:447–56.PubMed Boselli E, Jacquet-Lagrèze M, Ayoub JY, Bouvet L, Dauwalder O, Mansour C, Margez T, Paquet C, Restagno D, Allaouchiche B, Bonnet-Garin JM, Junot S. Effects of esmolol on systemic hemodynamics and heart rate variability measured using the analgesia/nociception index in resuscitated piglets with Pseudomonas aeruginosa septic shock. J Vet Emerg Crit Care (San Antonio). 2018;28:447–56.PubMed
62.
Zurück zum Zitat Bollag L, Ortner CM, Jelacic S, Rivat C, Landau R, Richebé P. The effects of low-dose ketamine on the analgesia nociception index (ANI) measured with the novel PhysioDoloris™ analgesia monitor: a pilot study. J Clin Monit Comput. 2015;29:291–5.PubMed Bollag L, Ortner CM, Jelacic S, Rivat C, Landau R, Richebé P. The effects of low-dose ketamine on the analgesia nociception index (ANI) measured with the novel PhysioDoloris™ analgesia monitor: a pilot study. J Clin Monit Comput. 2015;29:291–5.PubMed
63.
Zurück zum Zitat Anderson TA, Segaran JR, Toda C, Sabouri AS, De Jonckheere J. High-frequency heart rate variability index: a prospective, observational trial assessing utility as a marker for the balance between analgesia and nociception under general anesthesia. Anesth Analg. 2020;130:1045–53.PubMed Anderson TA, Segaran JR, Toda C, Sabouri AS, De Jonckheere J. High-frequency heart rate variability index: a prospective, observational trial assessing utility as a marker for the balance between analgesia and nociception under general anesthesia. Anesth Analg. 2020;130:1045–53.PubMed
64.
Zurück zum Zitat Michalot A, Bazin JÉ, Richebé P, Allaouchiche B, Boselli E. Effect of GOAL-Directed ANalgesia using ANI (Analgesia/Nociception Index) during general anesthesia on immediate postoperative pain and intraoperative hemodynamics in adult patients (GOALDAN study): a study protocol for randomized, controlled, multicenter trial. Trials. 2022;23:353.PubMedPubMedCentral Michalot A, Bazin JÉ, Richebé P, Allaouchiche B, Boselli E. Effect of GOAL-Directed ANalgesia using ANI (Analgesia/Nociception Index) during general anesthesia on immediate postoperative pain and intraoperative hemodynamics in adult patients (GOALDAN study): a study protocol for randomized, controlled, multicenter trial. Trials. 2022;23:353.PubMedPubMedCentral
65.
Zurück zum Zitat Gonzalez-Cava JM, Arnay R, León A, Martín M, Reboso JA, Calvo-Rolle JL, Mendez-Perez JA. Machine learning based method for the evaluation of the analgesia nociception index in the assessment of general anesthesia. Comput Biol Med. 2020;118: 103645.PubMed Gonzalez-Cava JM, Arnay R, León A, Martín M, Reboso JA, Calvo-Rolle JL, Mendez-Perez JA. Machine learning based method for the evaluation of the analgesia nociception index in the assessment of general anesthesia. Comput Biol Med. 2020;118: 103645.PubMed
66.
67.
Zurück zum Zitat Aragón-Benedí C, Oliver-Forniés P, Galluccio F, Yamak Altinpulluk E, Ergonenc T, El Sayed AA, Salazar C, Fajardo-Pérez M. Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study. PLoS ONE. 2021;16: e0249128.PubMedPubMedCentral Aragón-Benedí C, Oliver-Forniés P, Galluccio F, Yamak Altinpulluk E, Ergonenc T, El Sayed AA, Salazar C, Fajardo-Pérez M. Is the heart rate variability monitoring using the analgesia nociception index a predictor of illness severity and mortality in critically ill patients with COVID-19? A pilot study. PLoS ONE. 2021;16: e0249128.PubMedPubMedCentral
68.
Zurück zum Zitat Ramos-Luengo A, Gardeta Pallarés A, Asensio MF. Usefulness of ANI (analgesia nociception index) monitoring for outpatient saphenectomy surgery outcomes: an observational study. J Clin Monit Comput. 2021;35:491–7.PubMed Ramos-Luengo A, Gardeta Pallarés A, Asensio MF. Usefulness of ANI (analgesia nociception index) monitoring for outpatient saphenectomy surgery outcomes: an observational study. J Clin Monit Comput. 2021;35:491–7.PubMed
Metadaten
Titel
Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone
verfasst von
Keisuke Yoshida
Shinju Obara
Satoki Inoue
Publikationsdatum
22.10.2022
Verlag
Springer Nature Singapore
Erschienen in
Journal of Anesthesia / Ausgabe 1/2023
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-022-03126-8

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