nach oben

Graefe's Archive for Clinical and Experimental Ophthalmology

Erschienen in:

04.07.2019 | Retinal Disorders

Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography

verfasst von: Gözde Sahin, Derya Dal

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2019

Einloggen, um Zugang zu erhalten

Abstract

Objective

To detect retinal nerve fiber layer thickness differences of ambylopic and fellow eyes and ambylopic and control eyes.

Methods

The study comprised a total of 152 eyes recruited from Erzurum Region Training and Research Hospital, Turkey, between January 2018 and May 2018. Anisometropic amblyopia was the only cause of disability (visual acuity ≤ 6/12 and a difference in best-corrected visual acuity (BCVA) between the two eyes of 0.20 logMAR (2 lines on an acuity chart) in amblyopic eyes (n, 74) whereas normal eyes had a best-corrected visual acuity of 6/6 and no morbidities (n, 78). Anisometropic patients were divided into three groups as hyperopic, myopic, and cylindiric. All amblyopic eyes were compared with fellow eye and control group. Retinal nerve fiber layer thickness was analyzed using optic coherence tomography (OCT) (RTVue 100-2, Optovue, Inc. Fremont, CA).

Results

The mean age of the patients was 28.64 ± 8.23 years in amblyopia group and 32.23 ± 8.14 years in control group (p, 0.008). Mean best-corrected visual acuity (BCVA) was 0.36 ± 0.23 in amblyopic eyes, 0.96 ± 0.15 in fellow eyes, and 1.00 ± 0 in control group. Mean refractive error was 2.76 ± 7.84 in amblyopic eyes, 0.42 ± 1.34 in fellow eyes, and 0.12 ± 0.27 in control group. Temporal retinal nerve fiber layer thickness (RNFL-T) was 77.27 ± 10.38 μ, 79.31 ± 9.53 μ, and 81.46 ± 9.86 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.036). Superior RNFL-T was 136.23 ± 18.52 μ, 131.91 ± 13.80 μ, and 135.56 ± 14.94 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.204). Nasal RNFL-T was 87.99 ± 13.05 μ, 82.16 ± 12.33 μ, and 85.50 ± 10.62 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.014). Inferior RNFL-T was 144.85 ± 18.39 μ, 140.55 ± 16.92 μ, and 143.47 ± 17.75 μ respectively in ambylopic group, fellow eyes, and control eyes (p, 0.322). There was statistically significant difference in temporal and nasal quadrants and no statistical difference in superior and inferior quadrants.

Discussion

The presence of amblyopia seems not to be related with RNFL-T so we could ignore anisometropic amblyopia in patients with disease that could be detected and followed via RNFL thickness. Further and larger scaled studies are needed for certain results.

Simons K (2005) Amblyopia characterization, treatment, and prophylaxis. Surv Ophthalmol 50(2):123–166. https://doi.org/10.1016/j.survophthal.2004.12.005 CrossRefPubMed

Kim MH, Chung TY, Chung ES (2010) Long-term efficacy and rotational stability of AcrySof toric intraocular lens implantation in cataract surgery. Korean J Ophthalmol 24(4):207–212. https://doi.org/10.3341/kjo.2010.24.4.207 CrossRefPubMedPubMedCentral

Muckli L, Kiess S, Tonhausen N, Singer W, Goebel R, Sireteanu R (2006) Cerebral correlates of impaired grating perception in individual, psychophysically assessed human amblyopes. Vis Res 46(4):506–526. https://doi.org/10.1016/j.visres.2005.10.014 CrossRefPubMed

Miki A, Liu GT, Goldsmith ZG, Liu CS, Haselgrove JC (2003) Decreased activation of the lateral geniculate nucleus in a patient with anisometropic amblyopia demonstrated by functional magnetic resonance imaging. Ophthalmologica 217(5):365–369. https://doi.org/10.1159/000071353 CrossRefPubMed

Hess RF, Thompson B, Gole G, Mullen KT (2009) Deficient responses from the lateral geniculate nucleus in humans with amblyopia. Eur J Neurosci 29(5):1064–1070. https://doi.org/10.1111/j.1460-9568.2009.06650.x CrossRefPubMedPubMedCentral

Barnes GR, Li X, Thompson B, Singh KD, Dumoulin SO, Hess RF (2010) Decreased gray matter concentration in the lateral geniculate nuclei in human amblyopes. Invest Ophthalmol Vis Sci 51(3):1432–1438. https://doi.org/10.1167/iovs.09-3931 CrossRefPubMed

Bruce A, Pacey IE, Bradbury JA, Scally AJ, Barrett BT (2013) Bilateral changes in foveal structure in individuals with amblyopia. Ophthalmology 120(2):395–403. https://doi.org/10.1016/j.ophtha.2012.07.088 CrossRefPubMed

Lempert P (2008) Retinal area and optic disc rim area in amblyopic, fellow, and normal hyperopic eyes: a hypothesis for decreased acuity in amblyopia. Ophthalmology 115(12):2259–2261. https://doi.org/10.1016/j.ophtha.2008.07.016 CrossRefPubMed

Araki S, Miki A, Goto K, Yamashita T, Takizawa G, Haruishi K, Ieki Y, Kiryu J, Yaoeda K (2017) Macular retinal and choroidal thickness in unilateral amblyopia using swept-source optical coherence tomography. BMC Ophthalmol 17(1):167. https://doi.org/10.1186/s12886-017-0559-3 CrossRefPubMedPubMedCentral

10.

Al-Haddad CE, Mollayess GM, Cherfan CG, Jaafar DF, Bashshur ZF (2011) Retinal nerve fibre layer and macular thickness in amblyopia as measured by spectral-domain optical coherence tomography. Br J Ophthalmol 95(12):1696–1699. https://doi.org/10.1136/bjo.2010.195081 CrossRefPubMed

11.

Andalib D, Javadzadeh A, Nabai R, Amizadeh Y (2013) Macular and retinal nerve fiber layer thickness in unilateral anisometropic or strabismic amblyopia. J Pediatr Ophthalmol Strabismus 50(4):218–221. https://doi.org/10.3928/01913913-20130319-02 CrossRefPubMed

12.

Szigeti A, Tatrai E, Szamosi A, Vargha P, Nagy ZZ, Nemeth J, DeBuc DC, Somfai GM (2014) A morphological study of retinal changes in unilateral amblyopia using optical coherence tomography image segmentation. PLoS One 9(2):e88363. https://doi.org/10.1371/journal.pone.0088363 CrossRefPubMedPubMedCentral

13.

Dickmann A, Petroni S, Salerni A, Dell’Omo R, Balestrazzi E (2009) Unilateral amblyopia: an optical coherence tomography study. J AAPOS 13(2):148–150. https://doi.org/10.1016/j.jaapos.2008.10.009 CrossRefPubMed

14.

Miki A (2010) Retinal nerve fiber layer thickness in recovered and persistent amblyopia. Clin Ophthalmol. https://doi.org/10.2147/opth.S13145

15.

Yalcin E, Balci O (2014) Peripapillary retinal nerve fiber layer and foveal thickness in hypermetropic anisometropic amblyopia. Clin Ophthalmol 8:749–753. https://doi.org/10.2147/OPTH.S58541 CrossRefPubMedPubMedCentral

16.

Tugcu B, Araz-Ersan B, Kilic M, Erdogan ET, Yigit U, Karamursel S (2013) The morpho-functional evaluation of retina in amblyopia. Curr Eye Res 38(7):802–809. https://doi.org/10.3109/02713683.2013.779721 CrossRefPubMed

17.

Walker RA, Rubab S, Voll AR, Erraguntla V, Murphy PH (2011) Macular and peripapillary retinal nerve fibre layer thickness in adults with amblyopia. Can J Ophthalmol 46(5):425–427. https://doi.org/10.1016/j.jcjo.2011.07.013 CrossRefPubMed

18.

Wang BZ, Taranath D (2012) A comparison between the amblyopic eye and normal fellow eye ocular architecture in children with hyperopic anisometropic amblyopia. J AAPOS 16(5):428–430. https://doi.org/10.1016/j.jaapos.2012.06.006 CrossRefPubMed

19.

Xu J, Lu F, Liu W, Zhang F, Chen W, Chen J (2013) Retinal nerve fibre layer thickness and macular thickness in patients with esotropic amblyopia. Clin Exp Optom 96(3):267–271. https://doi.org/10.1111/cxo.12001 CrossRefPubMed

20.

Al-Haddad CE, El Mollayess GM, Mahfoud ZR, Jaafar DF, Bashshur ZF (2013) Macular ultrastructural features in amblyopia using high-definition optical coherence tomography. Br J Ophthalmol 97(3):318–322. https://doi.org/10.1136/bjophthalmol-2012-302434 CrossRefPubMed

21.

Dickmann A, Petroni S, Perrotta V, Salerni A, Parrilla R, Aliberti S, Savastano MC, Centra D, Discendenti S, Balestrazzi E (2011) A morpho-functional study of amblyopic eyes with the use of optical coherence tomography and microperimetry. J AAPOS 15(4):338–341. https://doi.org/10.1016/j.jaapos.2011.03.019 CrossRefPubMed

22.

Huynh SC, Samarawickrama C, Wang XY, Rochtchina E, Wong TY, Gole GA, Rose KA, Mitchell P (2009) Macular and nerve fiber layer thickness in amblyopia: the Sydney Childhood Eye Study. Ophthalmology 116(9):1604–1609. https://doi.org/10.1016/j.ophtha.2009.03.013 CrossRefPubMed

23.

Firat PG, Ozsoy E, Demirel S, Cumurcu T, Gunduz A (2013) Evaluation of peripapillary retinal nerve fiber layer, macula and ganglion cell thickness in amblyopia using spectral optical coherence tomography. Int J Ophthalmol 6(1):90–94. https://doi.org/10.3980/j.issn.2222-3959.2013.01.19 CrossRefPubMedPubMedCentral

24.

Kantarci FA, Tatar MG, Uslu H, Colak HN, Yildirim A, Goker H, Gurler B (2015) Choroidal and peripapillary retinal nerve fiber layer thickness in adults with anisometropic amblyopia. Eur J Ophthalmol 25(5):437–442. https://doi.org/10.5301/ejo.5000594 CrossRefPubMed

25.

Kim YW, Kim SJ, Yu YS (2013) Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients. Graefes Arch Clin Ophthalmol 251(12):2811–2819. https://doi.org/10.1007/s00417-013-2494-1 CrossRef

26.

Alotaibi AG, Al Enazi B (2011) Unilateral amblyopia: optical coherence tomography findings. Saudi J Ophthalmol 25(4):405–409. https://doi.org/10.1016/j.sjopt.2011.06.001 CrossRefPubMedPubMedCentral

27.

Lim HB, Sung JY, Ahn SI, Jo YJ, Kim JY (2018) Retinal nerve fiber layer thickness in various retinal diseases. Optom Vis Sci 95(3):247–255. https://doi.org/10.1097/OPX.0000000000001181 CrossRefPubMed

28.

Carta A, Mora P, Aldigeri R, Gozzi F, Favilla S, Tedesco S, Calzetti G, Farci R, Barboni P, Bianchi-Marzoli S, Fossarello M, Gandolfi S, Sadun AA (2018) Optical coherence tomography is a useful tool in the differentiation between true edema and pseudoedema of the optic disc. PLoS One 13(11):e0208145. https://doi.org/10.1371/journal.pone.0208145 CrossRefPubMedPubMedCentral

29.

Peng A, Kinoshita M, Lai W, Tan A, Qiu X, Zhang L, Li W, Chen L (2018) Retinal nerve fiber layer thickness in optic neuritis with MOG antibodies: a systematic review and meta-analysis. J Neuroimmunol 325:69–73. https://doi.org/10.1016/j.jneuroim.2018.09.011 CrossRefPubMed

30.

Shen T, You Y, Arunachalam S, Fontes A, Liu S, Gupta V, Parratt J, Wang C, Barnett M, Barton J, Chitranshi N, Zhu L, Fraser CL, Graham SL, Klistorner A, Yiannikas C (2018) Differing structural and functional patterns of optic nerve damage in multiple sclerosis and neuromyelitis optica spectrum disorder. Ophthalmology. https://doi.org/10.1016/j.ophtha.2018.06.022 CrossRef

31.

Casas P, Ascaso FJ, Vicente E, Tejero-Garces G, Adiego MI, Cristobal JA (2018) Visual field defects and retinal nerve fiber imaging in patients with obstructive sleep apnea syndrome and in healthy controls. BMC Ophthalmol 18(1):66. https://doi.org/10.1186/s12886-018-0728-z CrossRefPubMedPubMedCentral

32.

Blanch RJ, Micieli JA, Oyesiku NM, Newman NJ, Biousse V (2018) Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression. Pituitary 21(5):515–523. https://doi.org/10.1007/s11102-018-0906-2 CrossRef

33.

Sahin-Atik S, Koc F, Akin-Sari S, Ozmen M (2017) Retinal nerve fiber and optic disc morphology using spectral-domain optical coherence tomography in scleroderma patients. Eur J Ophthalmol 27(3):281–284. https://doi.org/10.5301/ejo.5000827 CrossRefPubMed

34.

Golzan SM, Goozee K, Georgevsky D, Avolio A, Chatterjee P, Shen K, Gupta V, Chung R, Savage G, Orr CF, Martins RN, Graham SL (2017) Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease. Alzheimers Res Ther 9(1):13. https://doi.org/10.1186/s13195-017-0239-9 CrossRefPubMedPubMedCentral

35.

Polo V, Satue M, Gavin A, Vilades E, Orduna E, Cipres M, Garcia-Campayo J, Navarro-Gil M, Larrosa JM, Pablo LE, Garcia-Martin E (2018) Ability of swept source OCT to detect retinal changes in patients with bipolar disorder. Eye. https://doi.org/10.1038/s41433-018-0261-6 CrossRef

36.

Coskun M, Sevencan NO (2018) The evaluation of ophthalmic findings in women patients with Iron and vitamin B12 deficiency anemia. Transl Vision Sci Technol 7(4):16. https://doi.org/10.1167/tvst.7.4.16 CrossRef

37.

Khan AO (2013) A comparison between the amblyopic eye and normal fellow eye ocular architecture in children with hyperopic anisometropic amblyopia. J AAPOS 17(1):115–116. https://doi.org/10.1016/j.jaapos.2012.11.001 CrossRefPubMed

38.

Hoekel J, Narayanan A, Rutlin J, Lugar H, Al-Lozi A, Hershey T, Tychsen L (2018) Visual pathway function and structure in Wolfram syndrome: patient age, variation and progression. BMJ Open Ophthalmol 3(1):e000081. https://doi.org/10.1136/bmjophth-2017-000081 CrossRefPubMedPubMedCentral

39.

Rohani M, Meysamie A, Zamani B, Sowlat MM, Akhoundi FH (2018) Reduced retinal nerve fiber layer (RNFL) thickness in ALS patients: a window to disease progression. J Neurol 265(7):1557–1562. https://doi.org/10.1007/s00415-018-8863-2 CrossRefPubMed

40.

Korkmaz S, Guclu H, Hatipoglu ES, Ficicioglu S, Gurlu V, Ozal SA (2018) Metabolic syndrome may exacerbate macular and retinal damage in psoriasis vulgaris. Ocul Immunol Inflamm:1–7. https://doi.org/10.1080/09273948.2018.1476556 CrossRef

41.

Matlach J, Wagner M, Malzahn U, Schmidtmann I, Steigerwald F, Musacchio T, Volkmann J, Grehn F, Gobel W, Klebe S (2018) Retinal changes in Parkinson’s disease and glaucoma. Parkinsonism Relat Disord. https://doi.org/10.1016/j.parkreldis.2018.06.016 CrossRef

42.

Moschos MM, Mostrou G, Psimenidou E, Spoulou V, Theodoridou M (2007) Objective analysis of retinal function in HIV-positive children without retinitis using optical coherence tomography. Ocul Immunol Inflamm 15(4):319–323. https://doi.org/10.1080/09273940701375154 CrossRefPubMed

43.

Akay F, Gundogan FC, Yolcu U, Toyran S, Tunc E, Uzun S (2016) Retinal structural changes in systemic arterial hypertension: an OCT study. Eur J Ophthalmol 26(5):436–441. https://doi.org/10.5301/ejo.5000740 CrossRefPubMed

44.

Kalenderoglu A, Celik M, Sevgi-Karadag A, Egilmez OB (2016) Optic coherence tomography shows inflammation and degeneration in major depressive disorder patients correlated with disease severity. J Affect Disord 204:159–165. https://doi.org/10.1016/j.jad.2016.06.039 CrossRefPubMed

45.

Ugurlu E, Pekel G, Altinisik G, Bozkurt K, Can I, Evyapan F (2018) New aspect for systemic effects of COPD: eye findings. Clin Respir J 12(1):247–252. https://doi.org/10.1111/crj.12523 CrossRefPubMed

46.

Repka MX, Kraker RT, Tamkins SM, Suh DW, Sala NA, Beck RW (2009) Retinal nerve fiber layer thickness in amblyopic eyes. Am J Ophthalmol 148(1):143–147. https://doi.org/10.1016/j.ajo.2009.01.015 CrossRefPubMedPubMedCentral

47.

Gunay M, Dogru M, Celik G, Gunay BO (2018) Swept-source optical coherence tomography analysis in asthmatic children under inhaled corticosteroid therapy. Cutan Ocul Toxicol:1–5. https://doi.org/10.1080/15569527.2018.1539009 CrossRef

48.

Lee JY, Choi JH, Park KA, Oh SY (2018) Ganglion cell layer and inner plexiform layer as predictors of vision recovery in ethambutol-induced optic neuropathy: a longitudinal OCT analysis. Invest Ophthalmol Vis Sci 59(5):2104–2109. https://doi.org/10.1167/iovs.17-22988 CrossRefPubMed

49.

Gemelli H, Fidalgo TM, Gracitelli CPB, de Andrade EP (2018) Retinal nerve fiber layer analysis in cocaine users. Psychiatry Res 271:226–229. https://doi.org/10.1016/j.psychres.2018.11.058 CrossRefPubMed

50.

Wu SQ, Zhu LW, Xu QB, Xu JL, Zhang Y (2013) Macular and peripapillary retinal nerve fiber layer thickness in children with hyperopic anisometropic amblyopia. Int J Ophthalmol 6(1):85–89. https://doi.org/10.3980/j.issn.2222-3959.2013.01.18 CrossRefPubMedPubMedCentral

51.

Yakar K, Kan E, Alan A, Alp MH, Ceylan T (2015) Retinal nerve fibre layer and macular thicknesses in adults with hyperopic anisometropic amblyopia. J Ophthalmol 2015:946467. https://doi.org/10.1155/2015/946467 CrossRefPubMedPubMedCentral

52.

Varma R, Bazzaz S, Lai M (2003) Optical tomography–measured retinal nerve fiber layer thickness in normal Latinos. Invest Opthalmol Vis Sci 44(8):3369. https://doi.org/10.1167/iovs.02-0975 CrossRef

53.

Poinoosawmy D, Fontana L, Wu JX (1997) Variation of nerve fibre layer thickness measurements with age and ethnicity by scanning laser polarimetry. Br J Ophthalmol 81:350–354CrossRef

54.

El-Dairi MA, Asrani SG, Enyedi LB (2009) Optical coherence tomography in the eyes of normal children. Arch Ophthalmol 127:50–58CrossRef

55.

Huynh SC, Wang XY, Rochtchina E, Mitchell P (2006) Peripapillary retinal nerve fiber layer thickness in a population of 6-year-old children: findings by optical coherence tomography. Ophthalmology 113(9):1583–1592. https://doi.org/10.1016/j.ophtha.2006.02.067 CrossRefPubMed

56.

Wagner-Schuman M, Dubis AM, Nordgren RN, Lei Y, Odell D, Chiao H, Weh E, Fischer W, Sulai Y, Dubra A, Carroll J (2011) Race- and sex-related differences in retinal thickness and foveal pit morphology. Invest Ophthalmol Vis Sci 52(1):625–634. https://doi.org/10.1167/iovs.10-5886 CrossRefPubMedPubMedCentral

57.

von Noorden GK, Crawford ML, Levacy R (1983) The lateral geniculate nucleus in human anisometropic amblyopia. Invest Ophthalmol Vis Sci 24:788–790

58.

von Noorden GK, Crawford ML (1992) The lateral geniculate nucleus in human strabismic amblyopia. Invest Ophthalmol Vis Sci 33:2729–2732 27,28

59.

Crawford ML, von Noorden GK (1980) Optically induced concomitant strabismus in monkeys. Invest Ophthalmol Vis Sci 19:1105–1109PubMed

60.

Wiesel TN, Hubel DH (1963) Effects of visual deprivation on morphology and physiology of cells in the cats lateral geniculate body. J Neurophysiol 26:978–993CrossRef

Titel: Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography
verfasst von: Gözde Sahin
Derya Dal
Publikationsdatum: 04.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04402-2

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography

Abstract

Objective

Methods

Results

Discussion

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Objective

Methods

Results

Discussion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2019

Phototoxicity of environmental radiations in human lens: revisiting the pathogenesis of UV-induced cataract

Morphological changes of focal choroidal excavation

Exploration of potential key pathways and genes in multiple ocular cancers through bioinformatics analysis

Effect of topical steroids on recently developed incomplete nasolacrimal duct obstruction: optical coherence tomography study

Breakdown of the blood-eye barrier in choroidal melanoma after proton beam radiotherapy

Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde