nach oben

Graefe's Archive for Clinical and Experimental Ophthalmology

Erschienen in:

24.07.2019 | Retinal Disorders

Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole

verfasst von: Kosuke Takahashi, Yuki Morizane, Shuhei Kimura, Yusuke Shiode, Shinichiro Doi, Toshio Okanouchi, Ippei Takasu, Yasushi Inoue, Fumio Shiraga

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To investigate the outcomes of embedding lamellar hole-associated epiretinal proliferation (LHEP) into retinal cleavage for the surgical treatment of degenerative lamellar macular hole (LMH).

Methods

We retrospectively reviewed the medical records of 34 consecutive eyes of degenerative LMH patients who underwent vitrectomy with LHEP embedding and who were followed up for at least 12 months. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and macular structure preoperatively and at the final follow-up were compared.

Results

The mean (±SD) follow-up period was 30.0 ± 17.7 months. Twelve patients (35.3%) were men, and the mean age was 69.6 ± 10.1 years. Twenty-three eyes (67.6%) underwent simultaneous cataract surgery. BCVA was significantly improved at the final visit, from 0.31 ± 0.25 logarithm of the minimum angle of resolution units to 0.10 ± 0.25 (P < 0.01). This improvement in mean BCVA at the final postoperative visit occurred regardless of whether the eyes underwent simultaneous cataract surgery, from 0.30 ± 0.26 preoperatively to 0.04 ± 0.16 (P < 0.01) in the “with cataract surgery” group and from 0.32 ± 0.26 preoperatively to 0.21 ± 0.35 (P < 0.05) in the “without cataract surgery” group. CRT was also significantly improved at the final visit, from 123.2 ± 42.6 μm preoperatively to 191.2 ± 42.6 μm (P < 0.01). External limiting membrane and ellipsoid zone defects were detected in 17 (50.0%) and 15 (44.1%) eyes, respectively, but these were resolved in 10 (58.8%) and 7 (46.7%) eyes, respectively, at the final visit. No intraoperative or postoperative complications were observed.

Conclusions

Embedding LHEP may be an effective and safe procedure to treat degenerative LMH.

Nur mit Berechtigung zugänglich

Gass JD (1975) Lamellar macular hole: a complication of cystoid macular edema after cataract extraction: a clinicopathologic case report. Trans Am Ophthalmol Soc 73:231–250. https://doi.org/10.1001/archopht.1976.03910030391008 CrossRefPubMed

Duker JS, Kaiser PK, Binder S et al (2013) The international vitreomacular traction study group classification of vitreomacular adhesion, traction, and macular hole. Ophthalmology. 120:2611–2619. https://doi.org/10.1016/j.ophtha.2013.07.042 CrossRefPubMed

Witkin AJ, Ko TH, Fujimoto JG et al (2006) Redefining lamellar holes and the vitreomacular interface: an ultrahigh-resolution optical coherence tomography study. Ophthalmology 113:388–397. https://doi.org/10.1016/j.ophtha.2005.10.047 CrossRefPubMedPubMedCentral

Lai TT, Chen SN, Yang CM (2016) Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings. Graefes Arch Clin Exp Ophthalmol 254:629–638. https://doi.org/10.1007/s00417-015-3133-9 CrossRefPubMed

Dell'omo R, Virgili G, Rizzo S et al (2017) Role of lamellar hole-associated epiretinal proliferation in lamellar macular holes. Am J Ophthalmol 175:16–29. https://doi.org/10.1016/j.ajo.2016.11.007 CrossRefPubMed

Govetto A, Dacquay Y, Farajzadeh M et al (2016) Lamellar macular hole: two distinct clinical entities? Am J Ophthalmol 164:99–109. https://doi.org/10.1016/j.ajo.2016.02.008 CrossRefPubMed

Zampedri E, Romanelli F, Semeraro F et al (2017) Spectral-domain optical coherence tomography findings in idiopathic lamellar macular hole. Graefes Arch Clin Exp Ophthalmol 255:699–707. https://doi.org/10.1007/s00417-016-3545-1 CrossRefPubMed

Frisina R, Zampedri E, Marchesoni I et al (2016) Lamellar macular hole in high myopic eyes with posterior staphyloma: morphological and functional characteristics. Graefes Arch Clin Exp Ophthalmol 254:2141–2150. https://doi.org/10.1007/s00417-016-3371-5 CrossRef

Lai TT, Yang CM (2018) Lamellar hole-associated epiretinal proliferation in lamellar macular hole and full-thickness macular hole in high myopia. Retina 38:1316–1323. https://doi.org/10.1097/IAE.0000000000001708 CrossRefPubMed

10.

Gaudric A, Aloulou Y, Tadayoni R, Massin P (2013) Macular pseudoholes with lamellar cleavage of their edge remain pseudoholes. Am J Ophthalmol. https://doi.org/10.1016/j.ajo.2012.10.021 CrossRef

11.

Hirano M, Morizane Y, Kimura S et al (2018) Assessment of lamellar macular hole and macular pseudohole with a combination of en face and radial B-scan optical coherence tomography imaging. Am J Ophthalmol 188:29–40. https://doi.org/10.1016/j.ajo.2018.01.016 CrossRefPubMed

12.

Purtskhvanidze K, Balken L, Hamann T et al (2018) Long-term follow-up of lamellar macular holes and pseudoholes over at least 5 years. Graefes Arch Clin Exp Ophthalmol 256:1067–1078. https://doi.org/10.1007/s00417-018-3972-2 CrossRefPubMed

13.

Figueroa MS, Govetto A, Steel DH et al (2018) Pars plana vitrectomy for the treatment of tractional and degenerative lamellar macula holes: functional and anatomical results. Retina. https://doi.org/10.1097/IAE.0000000000002326 CrossRef

14.

Choi WS, Merlau DJ, Chang S (2018) Vitrectomy for macular disorders associated with lamellar macular hole epiretinal proliferation. Retina 38:664–669. https://doi.org/10.1097/IAE.0000000000001591 CrossRefPubMed

15.

Ko J, Kim GA, Lee SC et al (2016) Surgical outcomes of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation. Acta Ophthalmol 95:e221. https://doi.org/10.1111/aos.13245 CrossRefPubMed

16.

Parolini B, Schumann RG, Cereda MG et al (2011) Lamellar macular hole: a clinicopathologic correlation of surgically excised epiretinal membranes. Invest Ophthalmol Vis Sci 52:9074–9083. https://doi.org/10.1167/iovs.11-8227 CrossRefPubMed

17.

Itoh Y, Levison AL, Kaiser PK et al (2015) Prevalence and characteristics of hyporeflective preretinal tissue in vitreomacular interface disorders. Br J Ophthalmol 100:399–404. https://doi.org/10.1136/bjophthalmol-2015-306986 CrossRefPubMedPubMedCentral

18.

Shiraga F, Takasu I, Fukuda K et al (2013) Modified vitreous surgery for symptomatic lamellar macular hole with epiretinal membrane containing macular pigment. Retina 33:1263–1269. https://doi.org/10.1097/IAE.0b013e31828bcb61 CrossRefPubMed

19.

Shiode Y, Morizane Y, Takahashi K et al (2018) Embedding of lamellar hole-associated epiretinal proliferation combined with internal limiting membrane inversion for the treatment of lamellar macular hole: a case report. BMC Ophthalmol 18:257. https://doi.org/10.1186/s12886-018-0926-8 CrossRefPubMedPubMedCentral

20.

Schumann RG, Compera D, Schaumberger MM et al (2015) Epiretinal membrane characteristics correlate with photoreceptor layer defects in lamellar macular holes and macular pseudoholes. Retina 35:727–735. https://doi.org/10.1097/IAE.0000000000000375 CrossRefPubMed

21.

Michalewska Z, Michalewski J, Odrobina D et al (2010) Surgical treatment of lamellar macular holes. Graefes Arch Clin Exp Ophthalmol 248:1395–1400. https://doi.org/10.1007/s00417-010-1400-3 CrossRefPubMed

22.

Pang CE, Spaide RF, Freund KB (2014) Epiretinal proliferation seen in association with lamellar macular holes: a distinct clinical entity. Retina 34:1513–1523. https://doi.org/10.1097/IAE.0000000000000163 CrossRefPubMed

23.

Michalewska Z, Michalewski J, Adelman RA, Nawrocki J (2010) Inverted internal limiting membrane flap technique for large macular holes. Ophthalmology 117:2018–2025. https://doi.org/10.1016/j.ophtha.2010.02.011 CrossRefPubMed

24.

Shiode Y, Morizane Y, Matoba R et al (2017) The role of inverted internal limiting membrane flap in macular hole closure. Invest Ophthalmol Vis Sci 58:4847–4855. https://doi.org/10.1167/iovs.17-21756 CrossRefPubMed

25.

Tadayoni R, Paques M, Massin P et al (2001) Dissociated optic nerve fiber layer appearance of the fundus after idiopathic epiretinal membrane removal. Ophthalmology 108:2279–2283CrossRef

26.

Alkabes M, Salinas C, Vitale L et al (2011) En face optical coherence tomography of inner retinal defects after internal limiting membrane peeling for idiopathic macular hole. Invest Ophthalmol Vis Sci 52:8349–8355. https://doi.org/10.1167/iovs.11-8043 CrossRefPubMed

27.

Michels RG (1982) A clinical and histopathologic study of epiretinal membranes affecting the macula and removed by vitreous surgery. Trans Am Ophthalmol Soc 80:580–656PubMedPubMedCentral

28.

Guidry C, Bradley KM, King JL (2003) Tractional force generation by human müller cells: growth factor responsiveness and integrin receptor involvement. Invest Ophthalmol Vis Sci 44:1355–1363. https://doi.org/10.1167/iovs.02-0046 CrossRefPubMed

29.

Qiao H, Hisatomi T, Sonoda KH et al (2005) The characterisation of hyalocytes: the origin, phenotype, and turnover. Br J Ophthalmol 89:513–517. https://doi.org/10.1136/bjo.2004.050658 CrossRefPubMedPubMedCentral

30.

Kohno RI, Hata Y, Kawahara S et al (2009) Possible contribution of hyalocytes to idiopathic epiretinal membrane formation and its contraction. Br J Ophthalmol 93:1020–1026. https://doi.org/10.1136/bjo.2008.155069 CrossRefPubMed

Titel: Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole
verfasst von: Kosuke Takahashi
Yuki Morizane
Shuhei Kimura
Yusuke Shiode
Shinichiro Doi
Toshio Okanouchi
Ippei Takasu
Yasushi Inoue
Fumio Shiraga
Publikationsdatum: 24.07.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2019
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04425-9

Update Augenheilkunde

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2019

Morphological changes of focal choroidal excavation

Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography

Postoperative pain following Descemet membrane endothelial keratoplasty (DMEK): a prospective study

Comparison of conjunctival vascularity changes using optical coherence tomography angiography after trabeculectomy and phacotrabeculectomy

Posterior segment eye lesions: prevalence and associations with ocular and systemic parameters: results from the Gutenberg Health Study

Comparing effects of photodynamic therapy in central serous chorioretinopathy: full-dose versus half-dose versus half-dose-half-fluence

Neu im Fachgebiet Augenheilkunde

Ophthalmika in der Schwangerschaft

Operative Therapie und Keimnachweis bei endogener Endophthalmitis

Bakterielle endogene Endophthalmitis

So erreichen Sie eine bestmögliche Wundheilung der Kornea

Update Augenheilkunde