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Archives of Virology

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01.03.2018 | Original Article

Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis

verfasst von: Naoki Takizawa, Tomoyuki Kimura, Takumi Watanabe, Masakatsu Shibasaki

Erschienen in: Archives of Virology | Ausgabe 6/2018

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Abstract

Influenza virus infection is a major threat to global health. Although vaccines and anti-influenza virus drugs are available, annual influenza virus epidemics result in severe illness, and an influenza pandemic occurs every 20–30 years. To identify candidate anti-influenza virus compounds, we screened approximately 5,000 compounds in an in-house library. We identified MZ7465, a salcomine derivative, as a potent inhibitor of influenza virus propagation. We analyzed the antiviral propagation mechanism of the hit compound by determining the amounts of viral proteins and RNA in infected cells treated with or without the hit compound. Treatment of infected cells with MZ7465 decreased both viral protein and RNA synthesis. In addition, an in vitro assay showed that viral RNA synthesis was directly inhibited by MZ7465. These results suggest that salcomine and its derivatives are potential candidates for the treatment of influenza virus infections.

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Titel: Anti-influenza virus activity of a salcomine derivative mediated by inhibition of viral RNA synthesis
verfasst von: Naoki Takizawa
Tomoyuki Kimura
Takumi Watanabe
Masakatsu Shibasaki
Publikationsdatum: 01.03.2018
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 6/2018
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-018-3779-9

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