Introduction
Methods
Results
Organism | Antibiotic | Geographic region | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
West | Midwest | Northeast | South | ||||||||||
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 | ||
S. aureus
| Vancomycin | 389 | 0.0 | 1 | 659 | 0.0 | 1 | 414 | 0.0 | 1 | 233 | 0.0 | 1 |
Besifloxacin | 389 | NA | 0.5 | 659 | NA | 1 | 414 | NA | 1 | 233 | NA | 2 | |
Moxifloxacin | 389 | 26.5 | 4 | 659 | 33.7 | 4 | 414 | 33.8 | 8 | 233 | 45.1 | 8 | |
Gatifloxacin | 345 | 26.1 | 4 | 605 | 33.4 | 4 | 363 | 36.1 | 8 | 182 | 47.8 | 16 | |
Ciprofloxacin | 389 | 27.5 | 32 | 659 | 35.7 | 128 | 414 | 37.2 | 256 | 233 | 47.2 | 256 | |
Levofloxacin | 345 | 26.4 | 8 | 605 | 33.7 | 16 | 363 | 36.1 | 32 | 182 | 47.8 | 128 | |
Ofloxacin | 345 | 27.0 | > 8 | 605 | 34.1 | > 8 | 363 | 37.2 | > 8 | 182 | 47.8 | > 8 | |
Clindamycin | 389 | 15.7 | > 2 | 659 | 17.2 | > 2 | 414 | 13.8 | > 2 | 233 | 12.9 | > 2 | |
Chloramphenicol | 345 | 2.9 | 8 | 605 | 8.4 | 8 | 363 | 5.8 | 8 | 182 | 5.0 | 8 | |
Azithromycin | 389 | 49.4 | > 512 | 659 | 62.5 | > 512 | 414 | 64.0 | > 512 | 233 | 67.8 | > 512 | |
Tobramycin | 389 | 11.6 | 32 | 659 | 17.8 | 256 | 414 | 19.6 | 256 | 233 | 22.3 | 256 | |
Tetracycline | 148 | 2.0 | 0.5 | 188 | 6.9 | 0.5 | 74 | 2.7 | 0.5 | 9 | 0.0 | – | |
Trimethoprim | 345 | 2.6 | 2 | 605 | 3.6 | 4 | 363 | 4.1 | 2 | 182 | 10.4 | 16 | |
MRSA | Vancomycin | 95 | 0.0 | 1 | 264 | 0.0 | 1 | 149 | 0.0 | 1 | 113 | 0.0 | 1 |
Besifloxacin | 95 | NA | 1 | 264 | NA | 1 | 149 | NA | 4 | 113 | NA | 2 | |
Moxifloxacin | 95 | 87.4 | 8 | 264 | 62.1 | 8 | 149 | 77.9 | 32 | 113 | 78.8 | 16 | |
Gatifloxacin | 81 | 85.2 | 8 | 241 | 62.2 | 8 | 135 | 79.3 | 64 | 86 | 83.7 | 16 | |
Ciprofloxacin | 95 | 88.4 | 256 | 264 | 65.5 | 256 | 149 | 80.5 | 256 | 113 | 81.4 | 256 | |
Levofloxacin | 81 | 86.4 | 32 | 241 | 62.7 | 32 | 135 | 80.0 | 256 | 86 | 83.7 | 128 | |
Ofloxacin | 81 | 86.4 | 64 | 241 | 63.5 | > 8 | 135 | 80.0 | > 8 | 86 | 83.7 | > 8 | |
Clindamycin | 95 | 37.9 | > 16 | 264 | 33.0 | > 2 | 149 | 29.5 | > 2 | 113 | 18.6 | > 2 | |
Chloramphenicol | 81 | 6.2 | 8 | 241 | 13.3 | 16 | 135 | 11.1 | 16 | 86 | 5.8 | 8 | |
Azithromycin | 95 | 87.4 | > 512 | 264 | 93.6 | > 512 | 149 | 95.3 | > 512 | 113 | 92.0 | > 512 | |
Tobramycin | 95 | 35.8 | > 256 | 264 | 38.6 | 256 | 149 | 49.0 | > 256 | 113 | 40.7 | 256 | |
Tetracycline | 30 | 6.7 | 0.5 | 57 | 12.3 | 16 | 15 | 6.7 | 4 | 1 | 0.0 | – | |
Trimethoprim | 81 | 0.0 | 2 | 241 | 2.9 | 2 | 135 | 8.2 | 4 | 86 | 16.3 | > 128 | |
MSSA | Vancomycin | 294 | 0.0 | 1 | 395 | 0.0 | 1 | 265 | 0.0 | 1 | 120 | 0.0 | 1 |
Besifloxacin | 294 | NA | 0.06 | 395 | NA | 0.25 | 265 | NA | 0.25 | 120 | NA | 0.25 | |
Moxifloxacin | 294 | 6.8 | 0.12 | 395 | 14.7 | 2 | 265 | 9.1 | 0.5 | 120 | 13.3 | 1 | |
Gatifloxacin | 264 | 8.0 | 0.25 | 364 | 14.3 | 2 | 228 | 10.5 | 1 | 96 | 15.6 | 2 | |
Ciprofloxacin | 294 | 7.8 | 1 | 395 | 15.7 | 8 | 265 | 12.8 | 4 | 120 | 15.0 | 8 | |
Levofloxacin | 264 | 8.0 | 0.5 | 364 | 14.6 | 4 | 228 | 10.1 | 2 | 96 | 15.6 | 8 | |
Ofloxacin | 264 | 8.7 | 1 | 364 | 14.6 | 8 | 228 | 11.9 | 8 | 96 | 15.6 | > 8 | |
Clindamycin | 294 | 8.5 | 0.25 | 395 | 6.6 | 0.25 | 265 | 4.9 | 0.12 | 120 | 7.5 | 0.25 | |
Chloramphenicol | 264 | 1.9 | 8 | 364 | 5.2 | 8 | 228 | 2.6 | 8 | 96 | 4.2 | 8 | |
Azithromycin | 294 | 37.1 | > 512 | 395 | 41.8 | > 512 | 265 | 46.4 | > 512 | 120 | 45.0 | > 512 | |
Tobramycin | 294 | 3.7 | 0.5 | 395 | 3.8 | 0.5 | 265 | 3.0 | 1 | 120 | 5.0 | 1 | |
Tetracycline | 118 | 0.9 | 0.5 | 131 | 4.6 | 0.5 | 59 | 1.7 | 0.5 | 8 | 0.0 | – | |
Trimethoprim | 264 | 3.4 | 2 | 364 | 4.1 | 4 | 228 | 1.8 | 2 | 96 | 5.2 | 2 |
Organism | Antibiotic | Geographic region | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
West | Midwest | Northeast | South | ||||||||||
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 | ||
CoNS | Vancomycin | 397 | 0.0 | 2 | 548 | 0.0 | 2 | 350 | 0.0 | 2 | 180 | 0.0 | 2 |
Besifloxacin | 397 | NA | 2 | 548 | NA | 2 | 350 | NA | 2 | 180 | NA | 2 | |
Moxifloxacin | 397 | 27.2 | 8 | 548 | 30.8 | 16 | 350 | 31.4 | 16 | 180 | 40.0 | 16 | |
Gatifloxacin | 371 | 30.2 | 16 | 505 | 33.7 | 16 | 311 | 32.8 | 16 | 144 | 38.9 | 32 | |
Ciprofloxacin | 397 | 31.7 | 64 | 548 | 34.7 | 64 | 350 | 34.6 | 64 | 180 | 43.3 | 64 | |
Levofloxacin | 371 | 30.7 | 128 | 505 | 33.7 | 128 | 311 | 33.8 | 128 | 144 | 38.9 | 128 | |
Ofloxacin | 371 | 31.3 | > 8 | 505 | 34.3 | > 8 | 311 | 33.8 | > 8 | 144 | 38.9 | > 8 | |
Clindamycin | 397 | 25.4 | > 2 | 548 | 27.6 | 8 | 350 | 26.9 | > 2 | 180 | 21.7 | > 2 | |
Chloramphenicol | 371 | 1.9 | 4 | 505 | 1.2 | 8 | 311 | 0.6 | 4 | 144 | 0.7 | 8 | |
Azithromycin | 397 | 61.0 | > 512 | 548 | 61.0 | > 512 | 350 | 61.1 | > 512 | 180 | 62.8 | > 512 | |
Tobramycin | 397 | 17.1 | 8 | 548 | 17.7 | 16 | 350 | 15.7 | 8 | 180 | 16.7 | 8 | |
Tetracycline | 154 | 17.5 | > 16 | 157 | 10.2 | 8 | 68 | 14.7 | 8 | 2 | 0.0 | – | |
Trimethoprim | 371 | 27.5 | 256 | 505 | 26.1 | > 128 | 311 | 29.3 | > 128 | 144 | 32.6 | > 128 | |
MRCoNS | Vancomycin | 175 | 0.0 | 2 | 295 | 0.0 | 2 | 155 | 0.0 | 2 | 92 | 0.0 | 2 |
Besifloxacin | 175 | NA | 4 | 295 | NA | 4 | 155 | NA | 4 | 92 | NA | 4 | |
Moxifloxacin | 175 | 46.9 | 32 | 295 | 49.8 | 32 | 155 | 55.5 | 32 | 92 | 58.7 | 32 | |
Gatifloxacin | 162 | 53.1 | 32 | 269 | 55.0 | 32 | 135 | 58.5 | 64 | 75 | 60.0 | 32 | |
Ciprofloxacin | 175 | 55.4 | 64 | 295 | 56.3 | 64 | 155 | 60.7 | 64 | 92 | 64.1 | 64 | |
Levofloxacin | 162 | 54.3 | 256 | 269 | 55.4 | 128 | 135 | 60.0 | 256 | 75 | 60.0 | 128 | |
Ofloxacin | 162 | 54.3 | 16 | 269 | 56.1 | 32 | 135 | 60.0 | > 8 | 75 | 60.0 | > 8 | |
Clindamycin | 175 | 39.4 | > 16 | 295 | 35.3 | > 16 | 155 | 37.4 | > 16 | 92 | 30.4 | > 2 | |
Chloramphenicol | 162 | 1.2 | 8 | 269 | 1.9 | 8 | 135 | 1.5 | 8 | 75 | 1.3 | 8 | |
Azithromycin | 175 | 78.3 | > 512 | 295 | 77.6 | > 512 | 155 | 78.7 | > 512 | 92 | 79.4 | > 512 | |
Tobramycin | 175 | 28.0 | 16 | 295 | 28.5 | 32 | 155 | 28.4 | 32 | 92 | 23.9 | 16 | |
Tetracycline | 65 | 23.1 | > 16 | 87 | 16.1 | > 16 | 23 | 8.7 | 2 | 1 | 0.0 | – | |
Trimethoprim | 162 | 40.1 | > 256 | 269 | 40.5 | > 256 | 135 | 45.2 | > 128 | 75 | 42.7 | > 128 | |
MSCoNS | Vancomycin | 222 | 0.0 | 2 | 253 | 0.0 | 2 | 195 | 0.0 | 2 | 88 | 0.0 | 2 |
Besifloxacin | 222 | NA | 0.25 | 253 | NA | 0.12 | 195 | NA | 0.25 | 88 | NA | 0.5 | |
Moxifloxacin | 222 | 11.7 | 1 | 253 | 8.7 | 0.25 | 195 | 12.3 | 1 | 88 | 20.5 | 2 | |
Gatifloxacin | 209 | 12.4 | 1 | 236 | 9.3 | 0.25 | 176 | 13.1 | 2 | 69 | 15.9 | 2 | |
Ciprofloxacin | 222 | 13.1 | 4 | 253 | 9.5 | 1 | 195 | 13.9 | 8 | 88 | 21.6 | 64 | |
Levofloxacin | 209 | 12.4 | 4 | 236 | 8.9 | 0.5 | 176 | 13.6 | 4 | 69 | 15.9 | 8 | |
Ofloxacin | 209 | 13.4 | 8 | 236 | 9.3 | 1 | 176 | 13.6 | 8 | 69 | 15.9 | > 8 | |
Clindamycin | 222 | 14.4 | 1 | 253 | 18.6 | > 2 | 195 | 18.5 | 2 | 88 | 12.5 | 1 | |
Chloramphenicol | 209 | 2.4 | 4 | 236 | 0.4 | 4 | 176 | 0.0 | 4 | 69 | 0.0 | 4 | |
Azithromycin | 222 | 47.3 | > 512 | 253 | 41.5 | > 512 | 195 | 47.2 | > 512 | 88 | 45.5 | > 512 | |
Tobramycin | 222 | 8.6 | 4 | 253 | 5.1 | 2 | 195 | 5.6 | 4 | 88 | 9.1 | 4 | |
Tetracycline | 89 | 13.5 | > 16 | 70 | 2.9 | 1 | 45 | 17.8 | 8 | 1 | 0.0 | – | |
Trimethoprim | 209 | 17.7 | 256 | 236 | 9.8 | 8 | 176 | 17.1 | 64 | 69 | 21.7 | > 128 |
Organism | Antibiotic | Geographic region | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
West | Midwest | Northeast | South | ||||||||||
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 |
n
| %R | MIC90 | ||
S. pneumoniae
| Besifloxacin | 121 | NA | 0.06 | 191 | NA | 0.06 | 103 | NA | 0.12 | 59 | NA | 0.06 |
Moxifloxacin | 121 | 0.0 | 0.12 | 191 | 0.0 | 0.25 | 103 | 1.0 | 0.25 | 59 | 0.0 | 0.12 | |
Gatifloxacin | 105 | 1.0 | 0.25 | 171 | 0.0 | 0.25 | 86 | 0.0 | 0.25 | 37 | 0.0 | 0.25 | |
Ciprofloxacin | 121 | NA | 1 | 191 | NA | 1 | 103 | NA | 2 | 59 | NA | 1 | |
Levofloxacin | 105 | 0.0 | 1 | 171 | 0.0 | 1 | 86 | 0.0 | 1 | 37 | 0.0 | 1 | |
Ofloxacin | 105 | 0.0 | 2 | 171 | 0.0 | 2 | 86 | 1.2 | 2 | 37 | 2.7 | 2 | |
Chloramphenicol | 121 | 4.1 | 4 | 191 | 2.1 | 4 | 103 | 2.9 | 4 | 59 | 0.0 | 2 | |
Penicillina | 121 | 22.3 | 0.25 | 191 | 41.9 | 1 | 103 | 30.1 | 1 | 59 | 33.9 | 2 | |
Azithromycin | 121 | 22.3 | 16 | 191 | 48.7 | 256 | 103 | 29.1 | 256 | 59 | 33.9 | 32 | |
Tobramycin | 121 | NA | 32 | 191 | NA | 32 | 103 | NA | 32 | 59 | NA | 32 | |
Tetracycline | 28 | 3.6 | 0.25 | 45 | 17.8 | > 4 | 18 | 5.6 | 0.25 | 1 | 0.0 | – | |
Trimethoprim | 105 | NA | 128 | 171 | NA | 128 | 86 | NA | 64 | 37 | NA | 32 | |
P. aeruginosa
| Vancomycin | 120 | NA | > 16 | 186 | NA | > 16 | 133 | NA | > 16 | 60 | NA | > 16 |
Besifloxacin | 138 | NA | 2 | 215 | NA | 4 | 154 | NA | 4 | 92 | NA | 4 | |
Moxifloxacin | 138 | NA | 4 | 215 | NA | 4 | 154 | NA | 4 | 92 | NA | 4 | |
Gatifloxacin | 120 | 3.3 | 1 | 186 | 7.5 | 2 | 133 | 4.5 | 2 | 60 | 8.3 | 2 | |
Ciprofloxacin | 138 | 4.3 | 0.5 | 215 | 8.8 | 1 | 154 | 3.3 | 0.25 | 92 | 6.5 | 0.5 | |
Levofloxacin | 120 | 2.5 | 1 | 186 | 7.5 | 1 | 133 | 3.0 | 1 | 60 | 8.3 | 1 | |
Ofloxacin | 120 | 3.3 | 1 | 186 | 9.7 | 2 | 133 | 6.8 | 2 | 60 | 10.0 | 2 | |
Azithromycin | 138 | NA | 512 | 215 | NA | 512 | 154 | NA | 512 | 92 | NA | 512 | |
Chloramphenicol | 138 | NA | 128 | 215 | NA | 128 | 154 | NA | 128 | 92 | NA | 128 | |
Polymyxin B | 120 | 1.7 | 2 | 186 | 12.4 | 4 | 133 | 12.0 | 4 | 60 | 3.3 | 2 | |
Tetracycline | 50 | NA | > 16 | 57 | NA | 16 | 36 | NA | 16 | 2 | NA | – | |
Tobramycin | 138 | 1.5 | 1 | 215 | 4.2 | 1 | 154 | 2.0 | 1 | 92 | 1.1 | 1 | |
H. influenzae
| Besifloxacin | 122 | NA | 0.03 | 273 | NA | 0.03 | 122 | NA | 0.03 | 69 | NA | 0.03 |
Moxifloxacin | 122 | 0.8 | 0.03 | 273 | 0.0 | 0.06 | 122 | 0.0 | 0.06 | 69 | 0.0 | 0.03 | |
Gatifloxacin | 108 | 0.9 | 0.015 | 252 | 0.0 | 0.015 | 108 | 0.0 | 0.015 | 45 | 0.0 | 0.015 | |
Ciprofloxacin | 122 | 0.8 | 0.015 | 273 | 0.0 | 0.015 | 122 | 0.0 | 0.015 | 69 | 0.0 | 0.015 | |
Levofloxacin | 108 | 0.9 | 0.03 | 252 | 0.0 | 0.03 | 108 | 0.0 | 0.03 | 45 | 0.0 | 0.015 | |
Ofloxacin | 108 | 0.9 | 0.06 | 252 | 0.0 | 0.03 | 108 | 0.0 | 0.06 | 45 | 0.0 | 0.03 | |
Azithromycin | 122 | 0.0 | 2 | 273 | 1.1 | 2 | 122 | 0.0 | 2 | 69 | 0.0 | 2 | |
Chloramphenicol | 122 | 0.0 | 0.5 | 273 | 0.7 | 0.5 | 122 | 0.8 | 0.5 | 69 | 0.0 | 1 | |
Penicillin | 122 | NA | > 4 | 273 | NA | > 4 | 122 | NA | > 4 | 69 | NA | > 4 | |
Polymyxin B | 108 | NA | 1 | 252 | NA | 2 | 108 | NA | 2 | 45 | NA | 2 | |
Tetracycline | 53 | 0.0 | 0. 5 | 89 | 2.3 | 0.5 | 11 | 18.2 | 8 | 7 | 0.0 | – | |
Tobramycin | 122 | NA | 2 | 273 | NA | 2 | 122 | NA | 2 | 69 | NA | 4 |